INT48673

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Context Info
Confidence 0.42
First Reported 1994
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.24
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
endothelial cells 1
IGKV2D-26 (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 3 100.00 Very High Very High Very High
fluoxetine 13 99.96 Very High Very High Very High
antagonist 5 99.64 Very High Very High Very High
cINOD 1 99.28 Very High Very High Very High
Serotonin 4 98.08 Very High Very High Very High
agonist 2 57.44 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 1 98.56 Very High Very High Very High
Stress 1 74.80 Quite High
Urological Neuroanatomy 1 64.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of a 5-HT3 receptor-mediated current by the selective serotonin uptake inhibitor, fluoxetine.
Negative_regulation (Inhibition) of a 5 associated with serotonin and fluoxetine
1) Confidence 0.42 Published 1994 Journal Neurosci. Lett. Section Title Doc Link 7523998 Disease Relevance 0 Pain Relevance 0.70
The potential pharmacokinetic and pharmacodynamic interactions between zileuton, a 5-lipoxygenase inhibitor, and naproxen, a nonsteroidal anti-inflammatory drug that acts as a cyclo-oxygenase inhibitor, have been investigated in 24 healthy volunteers.
Negative_regulation (inhibitor) of a 5 associated with inflammation and cinod
2) Confidence 0.41 Published 1995 Journal Clin Pharmacokinet Section Abstract Doc Link 8620667 Disease Relevance 0.10 Pain Relevance 0.10
The blockade of 5-HT(1A) autoreceptors occurring on administration of a selective serotonin reuptake inhibitor together with a 5-HT(1A) autoreceptor antagonist is responsible for the acute increase in 5-hydroxytryptamine (serotonin, 5-HT) levels observed under these circumstances.
Negative_regulation (blockade) of a 5 associated with antagonist, serotonin and ssri
3) Confidence 0.41 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14751404 Disease Relevance 0.06 Pain Relevance 0.55
The purpose of the present study was to investigate whether 5-hydroxytryptamine (5-HT, serotonin) affects migration of vascular endothelial cells. 5-HT significantly enhanced migration of human aortic endothelial cells (HAECs), and this enhancement was completely inhibited by GR 55562, a 5-HT1 receptor antagonist, and fluoxetine, a 5-HT transporter inhibitor, but was not affected by ketanserin, a 5-HT2 receptor antagonist. 5-HT stimulation increased RhoA and ERK activity of HAECs, and inhibitors of RhoA (Y-27632 and H-1152) and inhibitors of MEK (U0126 and PD98059) abolished the 5-HT-induced increase in migration velocity.
Negative_regulation (inhibitor) of a 5 in endothelial cells associated with antagonist, serotonin and fluoxetine
4) Confidence 0.41 Published 2005 Journal FEBS Lett. Section Abstract Doc Link 16310780 Disease Relevance 0.07 Pain Relevance 0.25

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