INT48687

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Context Info
Confidence 0.54
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 3.51
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Plp1)
Anatomy Link Frequency
brain 1
frontal cortex 1
Plp1 (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 1 99.76 Very High Very High Very High
Glutamate 17 99.68 Very High Very High Very High
gABA 29 98.72 Very High Very High Very High
Multiple sclerosis 60 98.52 Very High Very High Very High
Spinal cord 57 98.24 Very High Very High Very High
Sciatic nerve 21 93.36 High High
alcohol 1 83.84 Quite High
Neuritis 30 75.00 Quite High
agonist 44 71.32 Quite High
sodium channel 5 69.56 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 99.68 Very High Very High Very High
Multiple Sclerosis 311 99.08 Very High Very High Very High
Demyelinating Disease 52 98.52 Very High Very High Very High
Epilepsy 10 92.84 High High
Stiff-person Syndrome 2 90.32 High High
Syndrome 17 88.40 High High
Ataxia 5 86.32 High High
Tonic-clonic Epilepsy 1 85.48 High High
Cerebral Palsy 43 84.56 Quite High
Generalized Anxiety Disorder 17 82.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two transcription factors (Scip and Krox20) regulating progression of myelination and myelin protein expression respectively, together with the expression of four myelin proteins (Pmp22, Mbp, Mag and Plp) were evaluated.
Gene_expression (expression) of Plp
1) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877074 Disease Relevance 0.15 Pain Relevance 0.08
This speculation can be supported by the observation that not all myelin protein levels were affected; we have shown in this study that the expression levels of CNPase and PLP were unchanged in non-EAE adult Olig1?
Gene_expression (levels) of PLP associated with multiple sclerosis
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.49 Pain Relevance 0.06
This speculation can be supported by the observation that not all myelin protein levels were affected; we have shown in this study that the expression levels of CNPase and PLP were unchanged in non-EAE adult Olig1?
Gene_expression (expression) of PLP associated with multiple sclerosis
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.49 Pain Relevance 0.06
Moreover, the expression level of PLP in the brain became comparable between 15 week-old WT and Olig1?
Gene_expression (expression) of PLP in brain
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.28 Pain Relevance 0.09
and proteolipid protein (PLP), are not differentially expressed in the
Neg (not) Gene_expression (expressed) of PLP
5) Confidence 0.30 Published 2008 Journal PPAR Research Section Body Doc Link PMC2581793 Disease Relevance 0.05 Pain Relevance 0.03
post-translational modification of myelin proteins [34] such as PLP, which is crucial for the
Gene_expression (crucial) of PLP
6) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2581793 Disease Relevance 0.19 Pain Relevance 0.07
Decreased levels of brain and CSF GABA, increased levels of CSF and cortical glutamate, and decreased levels of PLP in the frontal cortex, have been described in this condition.
Gene_expression (levels) of PLP in frontal cortex associated with glutamate, gaba and urological neuroanatomy
7) Confidence 0.13 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 1.53 Pain Relevance 0.42
The SPTLC2 and SPTLC3 subunits comprise a PLP consensus sequence which is absent in the SPTLC1 subunit.
Neg (absent) Gene_expression (absent) of PLP
8) Confidence 0.07 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2931514 Disease Relevance 0.15 Pain Relevance 0.04
OBJECTIVE: To study the intrathecal synthesis of anti-myelin basic protein (MBP) and anti-proteolipid protein (PLP) antibodies in patients in the early stages of multiple sclerosis.
Gene_expression (synthesis) of PLP associated with multiple sclerosis and intrathecal
9) Confidence 0.06 Published 1994 Journal Arch. Neurol. Section Abstract Doc Link 7524468 Disease Relevance 0.17 Pain Relevance 0.17

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