INT48688

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2007
Negated 2
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 1.94
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HTR4) plasma membrane (HTR4) cytoplasm (HTR4)
signal transducer activity (HTR4)
Anatomy Link Frequency
enterocytes 1
sensory neurons 1
urinary bladder 1
smooth muscle 1
sympathetic 1
HTR4 (Homo sapiens)
HTR4 - D100A (1)
Pain Link Frequency Relevance Heat
agonist 80 100.00 Very High Very High Very High
Serotonin 20 100.00 Very High Very High Very High
spastic colon 23 99.08 Very High Very High Very High
Clonidine 2 97.12 Very High Very High Very High
antagonist 34 95.52 Very High Very High Very High
epidural 1 94.64 High High
Central nervous system 2 91.12 High High
fluoxetine 4 90.68 High High
nud 2 87.16 High High
tetrodotoxin 2 83.36 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

16 99.08 Very High Very High Very High
Functional Bowel Disorder 10 98.88 Very High Very High Very High
Constipation 8 97.40 Very High Very High Very High
Disease 7 90.52 High High
Heart Rate Under Development 3 88.72 High High
Dyspepsia 2 87.16 High High
Stress 1 85.48 High High
Cv General 3 Under Development 1 82.80 Quite High
Abdominal Pain 4 80.40 Quite High
Skin Appendage Disease 1 56.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that the effect of 5-HT on short-circuit current of human ileal mucosa appears to be due to stimulation of a 5-HT4 receptor.
Positive_regulation (stimulation) of 5-HT4
1) Confidence 0.67 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7693492 Disease Relevance 0 Pain Relevance 0.16
In the alimentary tract, stimulation of 5-HT4 receptors has a pronounced effect on smooth muscle tone, mucosal electrolyte secretion, and the peristaltic reflex.
Positive_regulation (stimulation) of 5-HT4 in smooth muscle
2) Confidence 0.67 Published 1996 Journal FASEB J. Section Abstract Doc Link 8903510 Disease Relevance 0.08 Pain Relevance 0.13
In the urinary bladder, activation of 5-HT4 receptors modulates cholinergic/purinergic transmission.
Positive_regulation (activation) of 5-HT4 in urinary bladder
3) Confidence 0.67 Published 1996 Journal FASEB J. Section Abstract Doc Link 8903510 Disease Relevance 0.09 Pain Relevance 0.18
The drug's stimulation of 5-HT4 receptors on intestinal enterocytes increases peristaltic activity and fluid secretion into the gut lumen, facilitating stool passage.
Positive_regulation (stimulation) of 5-HT4 in enterocytes
4) Confidence 0.67 Published 2007 Journal Pharmacotherapy Section Abstract Doc Link 17253916 Disease Relevance 0.56 Pain Relevance 0.57
We hypothesized that 5-HT4 activation by tegaserod stimulates gas transit in healthy individuals.
Spec (hypothesized) Positive_regulation (activation) of 5-HT4
5) Confidence 0.67 Published 2006 Journal Am. J. Gastroenterol. Section Abstract Doc Link 16817836 Disease Relevance 0.18 Pain Relevance 0.40
These results suggest that mucosal stroking induces release of mucosal 5-HT, which activates a 5-HT4 receptor on enteric sensory neurons, evoking a neuronal reflex that stimulates chloride secretion.
Positive_regulation (activates) of 5-HT4 in sensory neurons
6) Confidence 0.49 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10484375 Disease Relevance 0 Pain Relevance 0.22
The 5-HT4 receptor agonists cisapride (1.0 mg/kg) and zacopride (1.0 mg/kg) failed to increase small intestinal transit.
Neg (failed) Positive_regulation (increase) of 5-HT4 associated with agonist
7) Confidence 0.49 Published 1996 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 8697180 Disease Relevance 0.06 Pain Relevance 0.19
Their prokinetic effect is thought to be due to the augmentation of acetylcholine release from the myenteric plexus, an effect likely to be mediated through the stimulation of 5-HT4 receptors.
Positive_regulation (stimulation) of 5-HT4
8) Confidence 0.49 Published 1996 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 8697180 Disease Relevance 0.09 Pain Relevance 0
Stimulation of 5-HT1A, 5-HT1B, 5-HT2A/2C, 5-HT3 and 5-HT4 receptors or 5-HT uptake inhibition: short- and long-term memory.
Positive_regulation (Stimulation) of 5-HT4
9) Confidence 0.45 Published 2007 Journal Behav. Brain Res. Section Title Doc Link 17692935 Disease Relevance 0 Pain Relevance 0.38
Patients who require cardiac beta-receptor blockers and suffer from side effects of these drugs might also benefit from surgical cardiac sympathetic denervation.
Positive_regulation (require) of cardiac beta-receptor in sympathetic
10) Confidence 0.43 Published 1994 Journal Eur J Surg Suppl Section Abstract Doc Link 7524789 Disease Relevance 0.31 Pain Relevance 0.13
These findings suggest that 5-HT facilitates cholinergic contraction in human airways in vitro through stimulation of both prejunctional 5-HT3 and 5-HT4 receptors.
Positive_regulation (stimulation) of 5-HT4
11) Confidence 0.21 Published 1999 Journal Eur. Respir. J. Section Abstract Doc Link 10543288 Disease Relevance 0.11 Pain Relevance 0.21
Another protein, NHERF appears to be involved in directing the 5–HT4(a) receptor to the microvilli region where the two proteins are co-localised with another protein called ezrin [42] that interacts with the membrane phosphatidylinositol-(4,5)-bisphosphate [9].
Positive_regulation (directing) of HT4
12) Confidence 0.05 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0 Pain Relevance 0.03
The first receptor in this series, 5-HT4-D100A or Rs1 (RASSL serotonin 1), is not activated by its endogenous agonist, serotonin, but is selectively activated by the small synthetic molecules GR113808, GR125487, and RO110-0235.
Neg (not) Positive_regulation (activated) of 5-HT4 (D100A) associated with agonist and serotonin
13) Confidence 0.02 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2267039 Disease Relevance 0 Pain Relevance 0.19

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