INT48690

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Context Info
Confidence 0.61
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 33
Total Number 34
Disease Relevance 6.13
Pain Relevance 16.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Grip2) plasma membrane (Grip2) cytoskeleton (Grip2)
cytoplasm (Grip2)
Anatomy Link Frequency
spinal 3
spinal cord 2
hippocampus 2
neurons 2
frontal cortex 2
Grip2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 216 100.00 Very High Very High Very High
noradrenaline 106 100.00 Very High Very High Very High
Calcitonin gene-related peptide 24 100.00 Very High Very High Very High
amygdala 12 99.98 Very High Very High Very High
agonist 10 99.98 Very High Very High Very High
Pain 16 99.92 Very High Very High Very High
nociceptor 14 99.92 Very High Very High Very High
Neuropeptide 20 99.84 Very High Very High Very High
nMDA receptor 41 99.82 Very High Very High Very High
gABA 40 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 7 100.00 Very High Very High Very High
Diabetes Mellitus 87 99.48 Very High Very High Very High
Urological Neuroanatomy 40 99.00 Very High Very High Very High
Pain 11 98.52 Very High Very High Very High
Cognitive Disorder 19 96.76 Very High Very High Very High
Nociception 7 96.20 Very High Very High Very High
Acute Liver Failure 12 95.40 Very High Very High Very High
Encephalopathy 7 94.48 High High
Opiate Addiction 2 93.96 High High
Coma 6 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interruption of cholinergic transmission by the combined application of atropine (10(-5) M) and pempidine (10(-4) M) was without effect on the AMPA-evoked release of [3H]GABA, but it reduced the N-methyl-D-aspartate- (in the absence of magnesium or presence of AMPA) evoked release of [3H]GABA in both compartments, these reductions being of similar amplitude than those observed with tetrodotoxin.
Localization (release) of AMPA associated with tetrodotoxin and gaba
1) Confidence 0.61 Published 1994 Journal Brain Res. Section Abstract Doc Link 7525008 Disease Relevance 0 Pain Relevance 0.56
The colocalization of CGRP receptor and AMPA receptor in the spinal dorsal horn neuron of rat: a morphological and electrophysiological study.
Localization (colocalization) of AMPA receptor in spinal associated with nociceptor and dorsal horn neuron
2) Confidence 0.52 Published 2007 Journal Neurosci. Lett. Section Title Doc Link 17287081 Disease Relevance 0 Pain Relevance 1.04
Furthermore, our results showed that the evoked discharge frequency of the wide dynamic range (WDR) neuron, one type of the dorsal horn neurons, increased significantly after micro-iontophoretic delivery of CGRP or AMPA alone tested by extracellular recording, indicating a functional colocalization of CGRP receptor and AMPA receptor in a single spinal dorsal horn neuron.
Localization (colocalization) of AMPA receptor in spinal associated with dorsal horn neuron, wide dynamic range and calcitonin gene-related peptide
3) Confidence 0.52 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17287081 Disease Relevance 0 Pain Relevance 0.61
The present study found that there was a colocalization of CGRP receptor and AMPA receptor in a single spinal dorsal horn neuron in rat determined by double immunofluorescence labeling image methods.
Localization (colocalization) of AMPA receptor in neuron associated with dorsal horn neuron and calcitonin gene-related peptide
4) Confidence 0.52 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17287081 Disease Relevance 0 Pain Relevance 0.51
The results of the present study found a morphological and functional colocalization of the CGRP receptor and AMPA receptor in a single dorsal horn neuron that involved in the transmission and modulation of sensory information from primary afferent to the spinal cord in rats.
Localization (colocalization) of AMPA receptor in spinal cord associated with dorsal horn neuron, spinal cord and calcitonin gene-related peptide
5) Confidence 0.52 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17287081 Disease Relevance 0 Pain Relevance 0.59
Homeostatic adaptations in the subcellular localization of calcium sensitive AMPA receptors within the BLA may be an important neural substrate for alterations in reward, autonomic function, and behavioral processes associated with opiate addiction.
Localization (localization) of AMPA in autonomic associated with addiction and opiate
6) Confidence 0.38 Published 2005 Journal Synapse Section Abstract Doc Link 16037950 Disease Relevance 0.09 Pain Relevance 0.88
Modification of glutamate receptor targeting may be a key mechanism mediating neural plasticity; however, evidence for alteration of amygdala AMPA receptor localization in response to drug self-administration is lacking.
Localization (localization) of AMPA receptor in neural associated with glutamate receptor and amygdala
7) Confidence 0.38 Published 2005 Journal Synapse Section Abstract Doc Link 16037950 Disease Relevance 0.09 Pain Relevance 0.59
NMDA sites are uniquely neuronal, whereas kainate and AMPA sites are localized on both neurons and astrocytes.
Localization (localized) of AMPA in astrocytes
8) Confidence 0.35 Published 1997 Journal Hepatology Section Abstract Doc Link 9049210 Disease Relevance 0.93 Pain Relevance 0.26
The glutamate receptors involved are AMPA type since the AMPA-evoked [(3)H]acetylcholine release was blocked by LY303070 and was potentiated by the antidesensitizing agent cyclothiazide.
Localization (release) of AMPA associated with glutamate receptor
9) Confidence 0.28 Published 2001 Journal Neuroscience Section Abstract Doc Link 11564428 Disease Relevance 0 Pain Relevance 0.49
These results suggest that the capacity of S18986-1 to enhance AMPA receptor-mediated release of noradrenaline in rat hippocampus and frontal cortex, could contribute to the cognition enhancing mechanisms of S18986-1.
Localization (release) of AMPA in frontal cortex associated with cognitive disorder, noradrenaline, urological neuroanatomy and hippocampus
10) Confidence 0.20 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10924919 Disease Relevance 0.27 Pain Relevance 0.48
In addition, S18986-1-induced stimulation of (S)-AMPA-evoked [3H]noradrenaline release was markedly attenuated in the presence of tetrodotoxin (1 microM) and in Ca(2+)-free buffer.
Localization (release) of AMPA associated with tetrodotoxin and noradrenaline
11) Confidence 0.20 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10924919 Disease Relevance 0.32 Pain Relevance 0.60
S18986-1 enhanced (S)-AMPA-mediated [3H]noradrenaline release to a greater extent than its corresponding (R)-enantiomer S19024-1 and racemic mixture S17951-1.
Localization (release) of AMPA associated with noradrenaline
12) Confidence 0.20 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10924919 Disease Relevance 0.25 Pain Relevance 0.61
However, S18986-1 between 30 and 1000 microM potently enhanced (+200%) (S)-AMPA-mediated [3H]noradrenaline release in both hippocampal and frontal cortex slices.
Localization (release) of AMPA in frontal cortex associated with noradrenaline and urological neuroanatomy
13) Confidence 0.20 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10924919 Disease Relevance 0.44 Pain Relevance 0.31
However, positive allosteric modulators of AMPA receptors such as aniracetam failed to potentiate AMPA-mediated noradrenaline release in hippocampal slices, whereas cyclothiazide potently enhanced (S)-AMPA-mediated [3H]noradrenaline release.
Localization (release) of AMPA associated with noradrenaline
14) Confidence 0.20 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10924919 Disease Relevance 0.13 Pain Relevance 0.53
However, positive allosteric modulators of AMPA receptors such as aniracetam failed to potentiate AMPA-mediated noradrenaline release in hippocampal slices, whereas cyclothiazide potently enhanced (S)-AMPA-mediated [3H]noradrenaline release.
Localization (release) of AMPA associated with noradrenaline
15) Confidence 0.20 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10924919 Disease Relevance 0.13 Pain Relevance 0.52
Moreover, 1, 2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide (NBQX) and 1-(4-aminophenyl)-3-methylcarbamoyl-4-methyl-3, 4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI-53655) but not (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5, 10-imine ((+)-MK-801), inhibited (S)-AMPA and S18986-induced stimulation of (S)-AMPA-mediated [3H]noradrenaline release.
Localization (release) of AMPA associated with noradrenaline
16) Confidence 0.20 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10924919 Disease Relevance 0.34 Pain Relevance 0.54
The AMPA(100 microM)-evoked release of neuropeptide Y-like immunoreactivity was strongly antagonized by 6-nitro-7-sulphamoylbenzo(f)quinoxaline-2-3-dione and by 1-aminophenyl-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine, but it was in part (15-20%) sensitive to dizocilpine.
Localization (release) of AMPA associated with neuropeptide
17) Confidence 0.17 Published 1997 Journal Neuroscience Section Abstract Doc Link 9300398 Disease Relevance 0 Pain Relevance 0.72
Tetrodotoxin (1 microM) abrogated the N-methyl-D-aspartate-evoked release and partly inhibited the release caused by glutamate, but did not modify significantly AMPA- or kainate-evoked release.
Localization (release) of AMPA associated with tetrodotoxin and glutamate
18) Confidence 0.17 Published 1997 Journal Neuroscience Section Abstract Doc Link 9300398 Disease Relevance 0 Pain Relevance 0.78
AMPA-evoked release was inhibited by the non-NMDA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)-quinoxaline (NBQX) but was not affected by TTX.
Localization (release) of AMPA associated with tetrodotoxin and antagonist
19) Confidence 0.17 Published 1998 Journal Neurochem. Res. Section Abstract Doc Link 9821153 Disease Relevance 0 Pain Relevance 0.68
NMDA and AMPA receptors evoke transmitter release from noradrenergic axon terminals in the rat spinal cord.
Localization (release) of AMPA in spinal cord associated with spinal cord
20) Confidence 0.17 Published 1998 Journal Neurochem. Res. Section Title Doc Link 9821153 Disease Relevance 0 Pain Relevance 0.67

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