INT48691

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Context Info
Confidence 0.59
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 20
Total Number 22
Disease Relevance 4.96
Pain Relevance 11.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tacr1) plasma membrane (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
macrophages 2
neurons 1
spinal cord 1
lungs 1
tracheas 1
Tacr1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 282 100.00 Very High Very High Very High
antagonist 108 100.00 Very High Very High Very High
Morphine 10 99.76 Very High Very High Very High
Antinociceptive 4 99.54 Very High Very High Very High
qutenza 52 99.12 Very High Very High Very High
tetrodotoxin 4 99.08 Very High Very High Very High
Inflammation 126 99.00 Very High Very High Very High
narcan 3 98.98 Very High Very High Very High
Analgesic 3 98.98 Very High Very High Very High
antidepressant 9 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pneumonia 21 99.40 Very High Very High Very High
Targeted Disruption 19 98.76 Very High Very High Very High
Pain 11 98.60 Very High Very High Very High
Depression 4 97.92 Very High Very High Very High
Sprains And Strains 13 97.76 Very High Very High Very High
Nociception 39 97.72 Very High Very High Very High
Anxiety Disorder 8 97.00 Very High Very High Very High
Vomiting 1 95.80 Very High Very High Very High
INFLAMMATION 119 94.96 High High
Emphysema 30 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Disruption of the substance P receptor (neurokinin-1) gene does not prevent upregulation of preprotachykinin-A mRNA in the spinal cord of mice following peripheral inflammation.
Negative_regulation (Disruption) of substance P receptor in spinal cord associated with inflammation, spinal cord and substance p
1) Confidence 0.59 Published 1999 Journal Eur. J. Neurosci. Section Title Doc Link 10564361 Disease Relevance 0.57 Pain Relevance 0.99
CSC itself induced a moderate secretion of SP from macrophages, and amplified NK1R responses to SP that were completely eliminated by blocking NK1R, and substantially reduced after inhibiting NF-kappaB.
Negative_regulation (blocking) of NK1R in macrophages associated with substance p
2) Confidence 0.58 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.62
To evaluate the direct effects of CS and SP on the NK1R expression and the involvement of nuclear factor (NF)-kappaB, macrophages were exposed to CS condensate (CSC) and/or SP without or with blocking NK1R or inhibiting NF-kappaB activation in vitro.
Negative_regulation (blocking) of NK1R in macrophages associated with substance p
3) Confidence 0.58 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.64
Mice lacking the NK1 receptor, the preferred receptor for substance P, demonstrate normal analgesic responses to morphine on the hot plate assay, but have been predicted, on the basis of conditioned place preference studies, to be insensitive to the rewarding properties of opiates.
Negative_regulation (lacking) of NK1 receptor associated with analgesic, opiate, morphine and substance p
4) Confidence 0.58 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527475 Disease Relevance 0.07 Pain Relevance 0.61
NK1 receptor immunostaining was performed after behavioral tests to confirm the effective removal of NK1R-expressing lamina I neurons in SP-SAP treated animals.
Negative_regulation (removal) of NK1R-expressing in neurons associated with substance p
5) Confidence 0.57 Published 2005 Journal Mol Pain Section Body Doc Link PMC1185563 Disease Relevance 0 Pain Relevance 0.38
As a therapeutic approach, blocking only the NK1 receptor is most likely insufficient, as most of the effects of tachykinins in the airways are mediated by more than one tachykinin receptor.
Negative_regulation (blocking) of NK1 receptor
6) Confidence 0.53 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.68 Pain Relevance 0.13
The phenotype of NK1R-/- mice was compared with that of acute pharmacological blockade of the tachykinin NK1 receptor on sensorimotor function and in assays relevant to depressive illness and anxiety.
Negative_regulation (blockade) of NK1 receptor associated with depression and anxiety disorder
7) Confidence 0.43 Published 2001 Journal Behav Pharmacol Section Abstract Doc Link 11742144 Disease Relevance 0.33 Pain Relevance 0.15
There was no effect of NK1 receptor blockade with L-760735 in guinea-pigs or GR205171 in rats, or deletion of the NK1 receptor in mice, on behaviour in the elevated plus-maze test for anxiolytic activity.
Negative_regulation (blockade) of NK1 receptor associated with anxiety disorder
8) Confidence 0.43 Published 2001 Journal Behav Pharmacol Section Abstract Doc Link 11742144 Disease Relevance 0.39 Pain Relevance 0.33
Pretreatment with the NK1R antagonist SR140333 significantly reduced the contractility in the NK1R WT but not in the NK1R-/- mice.
Negative_regulation (reduced) of NK1R associated with antagonist
9) Confidence 0.43 Published 2003 Journal Eur. Respir. J. Section Abstract Doc Link 12570101 Disease Relevance 0.16 Pain Relevance 0.41
In addition to its neurotransmitter/modulator role in pain perception, substance P (SP) is involved in a regulation of mood, as antagonists of its neurokinin-1 receptor (NK1r) have been found to have antidepressant-like effects in humans.
Negative_regulation (antagonists) of neurokinin-1 receptor associated with pain, antidepressant, neurotransmitter, antagonist and substance p
10) Confidence 0.42 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16819984 Disease Relevance 0.10 Pain Relevance 0.63
In addition to its neurotransmitter/modulator role in pain perception, substance P (SP) is involved in a regulation of mood, as antagonists of its neurokinin-1 receptor (NK1r) have been found to have antidepressant-like effects in humans.
Negative_regulation (antagonists) of NK1r associated with pain, antidepressant, neurotransmitter, antagonist and substance p
11) Confidence 0.42 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16819984 Disease Relevance 0.10 Pain Relevance 0.63
The behavioral sensitization by the NK1R antagonist in SP-SAP animals revealed a role of SP-driven FFI in controlling nociceptive responses.
Negative_regulation (antagonist) of NK1R associated with nociception, antagonist and substance p
12) Confidence 0.42 Published 2005 Journal Mol Pain Section Body Doc Link PMC1185563 Disease Relevance 0.64 Pain Relevance 0.74
However, the lack of the tachykinin NK1 receptor did not impair the CS-induced accumulation of lymphocytes in BAL fluid and lungs in our mouse model, nor did it affect the formation of peribronchial lymphoid follicles.
Negative_regulation (lack) of NK1 receptor in lungs
13) Confidence 0.39 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.28 Pain Relevance 0.24
In a pharmacological validation experiment using the NK1 receptor antagonist RP 67580, we confirmed the protective effect of absence of the NK1 receptor on CS-induced pulmonary inflammation.


Negative_regulation (absence) of NK1 receptor associated with inflammation, antagonist and pneumonia
14) Confidence 0.39 Published 2009 Journal Respir Res Section Abstract Doc Link PMC2689186 Disease Relevance 0.84 Pain Relevance 0.23
SP-induced NK1 receptor endocytosis was inhibited by the specific NK1 receptor antagonist, SR140333.
Negative_regulation (inhibited) of NK1 receptor associated with antagonist and substance p
15) Confidence 0.39 Published 1996 Journal Histochem. Cell Biol. Section Abstract Doc Link 8985744 Disease Relevance 0 Pain Relevance 0.50
However, the most striking finding of this analysis was the revelation that Nkx-2.5, a murine homeo box gene, is a unique discriminator of NK1R-dependent genes.
Negative_regulation (discriminator) of NK1R
16) Confidence 0.33 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.07 Pain Relevance 0.06
Blockade of the NK1 receptor has a number of potentially beneficial effects in medical care including the management of drug-induced emesis and the treatment of depression.
Negative_regulation (Blockade) of NK1 receptor associated with depression and vomiting
17) Confidence 0.28 Published 2002 Journal Rheum. Dis. Clin. North Am. Section Abstract Doc Link 12122921 Disease Relevance 0.27 Pain Relevance 0.29
This effect was further shown to be due to selective NK1 receptor blockade, since (2S,3S)-cis-3(2-methoxybenzylamino)-2-phenylpiperidine (CP-99,994; 3 mg/kg, i.p.) inhibited foot tapping, whereas its less active enantiomer (2R,3R)-cis-3(2-methoxybenzylamino)-2-phenylpiperidine (CP-100,263; 3 mg/kg, i.p.) had no effect.
Negative_regulation (blockade) of NK1 receptor in foot
18) Confidence 0.28 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11166289 Disease Relevance 0.24 Pain Relevance 0.37
Differential antinociceptive effects of sendide, a NK1-receptor antagonist, and morphine in the capsaicin test.
Negative_regulation (antagonist) of NK1-receptor associated with qutenza, analgesic, antagonist, antinociceptive and morphine
19) Confidence 0.20 Published 1994 Journal Brain Res. Section Title Doc Link 7525010 Disease Relevance 0 Pain Relevance 1.71
Capsaicinoids (chili pepper oil) increased fluid secretion by glands from WT mice five-fold, and this response was abolished by exposing the basolateral aspect of the tracheas to L-732,138 (10 micromol/l), a specific antagonist of the neurokinin-1 receptor.
Negative_regulation (antagonist) of neurokinin-1 receptor in tracheas associated with antagonist
20) Confidence 0.16 Published 2008 Journal Pflugers Arch. Section Abstract Doc Link 18509672 Disease Relevance 0.25 Pain Relevance 0.41

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