INT48693

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Context Info
Confidence 0.62
First Reported 1994
Last Reported 2011
Negated 34
Speculated 17
Reported most in Body
Documents 268
Total Number 285
Disease Relevance 191.88
Pain Relevance 31.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
plasma 16
endothelial cells 11
lung 5
epithelium 5
platelet 4
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1051 100.00 Very High Very High Very High
cytokine 654 100.00 Very High Very High Very High
metalloproteinase 419 100.00 Very High Very High Very High
anesthesia 145 100.00 Very High Very High Very High
agonist 681 99.84 Very High Very High Very High
analgesia 40 99.84 Very High Very High Very High
Inflammatory response 163 99.76 Very High Very High Very High
Regional anesthesia 4 99.52 Very High Very High Very High
imagery 627 99.40 Very High Very High Very High
cINOD 109 99.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 7084 100.00 Very High Very High Very High
INFLAMMATION 1271 100.00 Very High Very High Very High
Hypoxia 950 100.00 Very High Very High Very High
Breast Cancer 718 100.00 Very High Very High Very High
Injury 334 100.00 Very High Very High Very High
Prostate Cancer 299 100.00 Very High Very High Very High
Eye Disease 77 100.00 Very High Very High Very High
Age-related Macular Degeneration 558 99.92 Very High Very High Very High
Colon Cancer 303 99.92 Very High Very High Very High
Metastasis 1165 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In response to hypoxia, VEGF121 and VEGF165 mRNA were both remarkably increased, while there was no change in VEGF mRNA stability.
Neg (no) Regulation (change) of VEGF mRNA
1) Confidence 0.62 Published 2007 Journal J. Oral Pathol. Med. Section Body Doc Link 17448139 Disease Relevance 0.15 Pain Relevance 0
Higher extracellular VEGF in tumor tissue compared to normal tissue is in line with previous ex vivo findings demonstrating an up-regulation of VEGF in breast cancer compared to adjacent non-neoplastic tissue [24,25].
Regulation (regulation) of VEGF associated with cancer and breast cancer
2) Confidence 0.62 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2279135 Disease Relevance 0.72 Pain Relevance 0
Therefore our results do not rule out a possible regulation of VEGF by estradiol in breast cancer tumors.
Spec (possible) Regulation (regulation) of VEGF associated with cancer and breast cancer
3) Confidence 0.62 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2279135 Disease Relevance 2.01 Pain Relevance 0
However, pentoxifylline did not affect VEGF levels, although a similar improvement in maximal walking distance was achieved.
Neg (not) Regulation (affect) of VEGF
4) Confidence 0.62 Published 2001 Journal Clin. Sci. Section Abstract Doc Link 11524048 Disease Relevance 0.33 Pain Relevance 0.26
We then investigated the alterations of VEGF and its receptors in IIR-induced ALI.
Spec (investigated) Regulation (alterations) of VEGF associated with adult respiratory distress syndrome
5) Confidence 0.59 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.37 Pain Relevance 0
To verify if epithelial cell death was related to the down-regulation of VEGF and VEGFR-1, TUNEL and cytokeratin double staining was performed.
Regulation (regulation) of VEGF in epithelial cell associated with death
6) Confidence 0.59 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.33 Pain Relevance 0
Regulation of VEGF in diabetic patients with critical limb ischemia.
Regulation (Regulation) of VEGF in limb associated with diabetes mellitus and ischemia
7) Confidence 0.59 Published 2001 Journal Ann Vasc Surg Section Title Doc Link 11414092 Disease Relevance 1.49 Pain Relevance 0.32
We therefore set out to determine if the regulation of VEGF in patients with peripheral vascular disease differs in diabetic and nondiabetic patients.
Regulation (regulation) of VEGF associated with diabetes mellitus and increased venous pressure under development
8) Confidence 0.59 Published 2001 Journal Ann Vasc Surg Section Abstract Doc Link 11414092 Disease Relevance 1.25 Pain Relevance 0.23
We observed no significant effect on VEGF or bFGF during the 48 hour in vitro fluvastatin treatment.
Neg (no) Regulation (effect) of VEGF
9) Confidence 0.59 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.24 Pain Relevance 0
HHV-8 up-regulates the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR in endothelial cells.
Regulation (regulates) of vascular endothelial growth factor in endothelial cells
10) Confidence 0.59 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC1852096 Disease Relevance 1.09 Pain Relevance 0
The results pointed towards the potential of the expression pattern of VEGF as a tumour marker for the early diagnosis of metastatic NPC and also showed that presence of EBV was related to up regulation of VEGF [53].
Regulation (regulation) of VEGF associated with nasopharynx cancer, cancer and epstein-barr virus
11) Confidence 0.52 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.73 Pain Relevance 0
gene) and VEGF which both could be regulated via hypoxia response.
Regulation (regulated) of VEGF associated with hypoxia
12) Confidence 0.52 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.10 Pain Relevance 0.06
Inhibition of the stress response to breast cancer surgery by regional anesthesia and analgesia does not affect vascular endothelial growth factor and prostaglandin E2.
Neg (not) Regulation (affect) of vascular endothelial growth factor associated with stress, breast cancer, regional anesthesia and analgesia
13) Confidence 0.52 Published 2005 Journal Anesth. Analg. Section Title Doc Link 15616085 Disease Relevance 0.64 Pain Relevance 1.23
LD paclitaxel is best combined with antiangiogenic therapy targeting Vegf against tumors with low Vegf expression, where such combination could achieve dramatic responses without major toxicity.
Regulation (targeting) of Vegf associated with toxicity and cancer
14) Confidence 0.48 Published 2008 Journal J Transl Med Section Body Doc Link PMC2235830 Disease Relevance 0.74 Pain Relevance 0
Training had no effect on plasma VEGF at rest or in response to acute exercise, despite a significant increase in maximal walking time in the TMT group (915+/-533 to 1206+/-500 s; P=0.009) following the intervention.
Neg (no) Regulation (effect) of VEGF in plasma
15) Confidence 0.47 Published 2006 Journal Clin. Sci. Section Abstract Doc Link 16928196 Disease Relevance 0.20 Pain Relevance 0.12
There was no evidence of any significant lung disease in the normal necropsy lung tissue, but it is conceivable that the extrapulmonary disease process contributing to death might have affected VEGF levels.
Regulation (affected) of VEGF in lung associated with pulmonary disease, disease and death
16) Confidence 0.46 Published 2010 Journal American Journal of Physiology - Lung Cellular and Molecular Physiology Section Body Doc Link PMC2886605 Disease Relevance 1.15 Pain Relevance 0.03
We have previously explored changes in VEGFxxx isoform and receptor expression as mechanisms for regulating VEGF bioactivity (21).
Regulation (regulating) of VEGF
17) Confidence 0.46 Published 2010 Journal American Journal of Physiology - Lung Cellular and Molecular Physiology Section Body Doc Link PMC2886605 Disease Relevance 0 Pain Relevance 0.04
Hence, sampling VEGF in the extracellular space, where it exerts its effects, may add significant insight into its regulation in tumor tissue.
Regulation (regulation) of VEGF associated with cancer
18) Confidence 0.45 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2279135 Disease Relevance 0.84 Pain Relevance 0
Bevacizumab leads to rapid clearance of circulating VEGF, but is not known to affect VEGF bound to receptor, as the epitope on VEGF recognized by bevacizumab is in the VEGF-R binding region.
Regulation (affect) of VEGF
19) Confidence 0.45 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 1.00 Pain Relevance 0
Inappropriate activation of the hypoxia response pathway, is the major mechanism of VEGF transcriptional regulation in renal cell carcinoma.2 The HIF?
Regulation (regulation) of VEGF associated with hypoxia and renal cancer
20) Confidence 0.45 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 0.55 Pain Relevance 0

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