INT48714

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Context Info
Confidence 0.15
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.28
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER2, SERPINE1) extracellular space (SERPINE1) extracellular region (SERPINE1)
signal transducer activity (PTGER2)
PTGER2 (Homo sapiens)
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 97.12 Very High Very High Very High
Inflammatory mediators 2 95.52 Very High Very High Very High
cINOD 2 92.36 High High
Arthritis 2 91.56 High High
agonist 2 88.48 High High
Kinase C 2 72.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 97.12 Very High Very High Very High
Arthritis 2 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that PGE2 suppresses PAI-1 expression and synthesis by activation of the cAMP/PKA system and inhibition of the rate of gene transcription.
PGE2 Negative_regulation (suppresses) of Gene_expression (expression) of PAI-1
1) Confidence 0.15 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0 Pain Relevance 0.16
PGE2 (and PGE1) inhibited PAI-1 mRNA expression and secretion in a dose-dependent manner with an IC50 (for antigen secretion) of 4.6 x 10(-10) M and 8.7 x 10(-10) M, respectively.
PGE2 Negative_regulation (inhibited) of Gene_expression (expression) of PAI-1 mRNA
2) Confidence 0.13 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0.28 Pain Relevance 0.22

General Comments

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