INT48717

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Context Info
Confidence 0.66
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.64
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1) extracellular region (SERPINE1) plasma membrane (SERPINE1)
Anatomy Link Frequency
vascular endothelium 2
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 45 98.54 Very High Very High Very High
Pain 4 95.36 Very High Very High Very High
Kinase C 2 93.68 High High
Inflammation 49 86.24 High High
Inflammatory mediators 2 84.64 Quite High
Arthritis 2 80.68 Quite High
cINOD 5 76.16 Quite High
peptic ulcer disease 9 5.00 Very Low Very Low Very Low
Inflammatory marker 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pre-eclampsia 8 99.22 Very High Very High Very High
Cancer 153 97.80 Very High Very High Very High
Aseptic Necrosis Of Bone 6 97.60 Very High Very High Very High
Pain 4 95.36 Very High Very High Very High
Hematologic Neoplasms 39 93.04 High High
Adhesions 7 86.32 High High
INFLAMMATION 56 86.24 High High
Leukemia 12 85.04 High High
Apoptosis 29 82.44 Quite High
Arthritis 2 80.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, dysfunctional vascular endothelium, characterizing preeclampsia resulting to IUGR, is associated with increased PAI-1 release [54].
Positive_regulation (increased) of Localization (release) of PAI-1 in vascular endothelium associated with pre-eclampsia
1) Confidence 0.66 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2896837 Disease Relevance 0.52 Pain Relevance 0.04
However, there was no significant increase in PAI-1 antigen secreted into the culture medium after PMA (100-300 nM) treatment.
Neg (no) Positive_regulation (increase) of Localization (secreted) of PAI-1
2) Confidence 0.49 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0.20 Pain Relevance 0.27
Cyclic AMP agonists forskolin, Sp-cAMP, and IBMX mimic the effects of the PGEs. rhIL-1 beta stimulated the secretion of PAI-1 in a dose-dependent fashion under basal culture conditions; the effect was reversed by actinomycin D and the protein kinase inhibitors H7 and staurosporine but not KT-5720.
Positive_regulation (stimulated) of Localization (secretion) of PAI-1 associated with agonist
3) Confidence 0.49 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0.25 Pain Relevance 0.22
Mutations in several genes of the cag-PAI interfere with tyrosine phosphorylation and induction of interleukin-8 secretion [54].
Positive_regulation (induction) of Localization (secretion) of cag-PAI
4) Confidence 0.10 Published 2005 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC544872 Disease Relevance 0.05 Pain Relevance 0
In three of the four patients with high PAI and with osteonecrosis present 0.3, 2, and 6 years prior to Stanozolol Rx, there was no clinical improvement after 14-156 weeks of Rx despite normalization of stimulated tPA-Fx and PAI-Fx.
Positive_regulation (stimulated) of Localization (normalization) of PAI-Fx associated with aseptic necrosis of bone
5) Confidence 0.06 Published 1995 Journal Am. J. Hematol. Section Abstract Doc Link 7717367 Disease Relevance 0.59 Pain Relevance 0.27
ligands upregulate expression and release of PAI-1 from ECs [193], which would inhibit degradation of tumor-associated fibrin leading to EC migration, proliferation, and angiogenesis [231].
Positive_regulation (upregulate) of Localization (release) of PAI-1 associated with cancer
6) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.02 Pain Relevance 0.04

General Comments

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