INT48718

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Context Info
Confidence 0.69
First Reported 1994
Last Reported 2010
Negated 4
Speculated 5
Reported most in Abstract
Documents 109
Total Number 117
Disease Relevance 36.16
Pain Relevance 46.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
smooth muscle 4
basophils 3
fibroblasts 2
platelet 2
skin 2
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 1233 100.00 Very High Very High Very High
Opioid 67 100.00 Very High Very High Very High
mu opioid receptor 25 100.00 Very High Very High Very High
Analgesic 11 100.00 Very High Very High Very High
nMDA receptor 11 100.00 Very High Very High Very High
Enkephalin 10 100.00 Very High Very High Very High
agonist 1102 99.98 Very High Very High Very High
IPN 4 99.74 Very High Very High Very High
methadone 4 99.72 Very High Very High Very High
MU agonist 3 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperglycemia 168 99.88 Very High Very High Very High
Stress 606 99.86 Very High Very High Very High
Lung Cancer 30 99.84 Very High Very High Very High
Necrosis 69 99.82 Very High Very High Very High
Inflammatory Pain 4 99.74 Very High Very High Very High
Anxiety Disorder 646 99.48 Very High Very High Very High
Hyperalgesia 25 99.44 Very High Very High Very High
Cv Unclassified Under Development 173 99.20 Very High Very High Very High
Cancer 380 99.12 Very High Very High Very High
Congenital Anomalies 72 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phorbol esters, which activate PKC, enhance the thermal hyperalgesia in diabetic mice and enhance nociceptive responses after tissue injury induced by formalin.
Positive_regulation (activate) of PKC associated with nociception, kinase c, diabetes mellitus, thermal hyperalgesia and injury
1) Confidence 0.69 Published 2001 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11772275 Disease Relevance 1.29 Pain Relevance 1.05
Activation of protein kinase C (PKC) has been implicated in changes in pain perception.
Positive_regulation (Activation) of PKC associated with pain and kinase c
2) Confidence 0.69 Published 2001 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11772275 Disease Relevance 1.30 Pain Relevance 1.04
Thus, activation of PKC may underlie the neuronal sensitisation that produces hyperalgesia in diabetic neuropathy.
Positive_regulation (activation) of PKC in neuronal associated with hyperalgesia, kinase c and diabetic neuropathy
3) Confidence 0.69 Published 2001 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11772275 Disease Relevance 1.32 Pain Relevance 1.02
Electrophysiological experiments have shown that activation of PKC leads to long-lasting enhancement of excitatory amino acid-mediated currents in dorsal horn neurones and trigeminal neurones.
Positive_regulation (activation) of PKC in dorsal horn associated with kinase c, dorsal horn and excitatory amino acid
4) Confidence 0.69 Published 2001 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11772275 Disease Relevance 1.21 Pain Relevance 1.05
We found that nicotine, like phorbol 12-myristate 13-acetate, increased total protein kinase C (PKC) activity, while morphine and sphingosine decreased PKC activity, and nicotine reversed morphine inhibition of PKC activity.
Positive_regulation (increased) of PKC associated with kinase c, nicotine and morphine
5) Confidence 0.67 Published 1994 Journal Cell Growth Differ. Section Abstract Doc Link 7848904 Disease Relevance 0.94 Pain Relevance 1.64
In contrast, methadone unexpectedly increased PKC activity.
Positive_regulation (increased) of PKC associated with kinase c and methadone
6) Confidence 0.67 Published 1994 Journal Cell Growth Differ. Section Abstract Doc Link 7848904 Disease Relevance 0.96 Pain Relevance 1.68
The opening of mitoKATP channels will activate PKC possibly via the production of radical oxygen species [18].
Spec (possibly) Positive_regulation (activate) of PKC associated with kinase c
7) Confidence 0.59 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0 Pain Relevance 0.33
One possibility is that PKC activation regulates MuOR mRNA expression and thus the ability to generate functional receptors.
Positive_regulation (activation) of PKC associated with kinase c and mu opioid receptor
8) Confidence 0.57 Published 1997 Journal Anesthesiology Section Abstract Doc Link 9366465 Disease Relevance 0.17 Pain Relevance 0.93
Activation and translocation of protein kinase C (PKC) by N-methyl-D-aspartate receptor stimulation correlates with resistance to opioid drugs in experimental states of neuropathic pain, but the cellular mechanisms of resistance have not been identified.
Positive_regulation (Activation) of PKC associated with kinase c, nmda receptor, neuropathic pain and opioid
9) Confidence 0.57 Published 1997 Journal Anesthesiology Section Abstract Doc Link 9366465 Disease Relevance 0.17 Pain Relevance 0.95
RESULTS: MuOR mRNA levels decreased in a dose- and time-dependent manner after tetradecanoyl phorbol acetate (TPA) was administered to activate PKC.
Positive_regulation (activate) of PKC
10) Confidence 0.57 Published 1997 Journal Anesthesiology Section Body Doc Link 9366465 Disease Relevance 0.08 Pain Relevance 0
CONCLUSIONS: Mu opioid receptor mRNA levels are regulated by activation of PKC in a neuronal model.
Positive_regulation (activation) of PKC in neuronal
11) Confidence 0.57 Published 1997 Journal Anesthesiology Section Body Doc Link 9366465 Disease Relevance 0.06 Pain Relevance 0
Using a human neuroblastoma cell line, the authors tested the hypothesis that phorbol ester activation of PKC regulates MuOR mRNA levels.
Positive_regulation (activation) of PKC associated with neuroblastoma, kinase c and mu opioid receptor
12) Confidence 0.57 Published 1997 Journal Anesthesiology Section Abstract Doc Link 9366465 Disease Relevance 0.26 Pain Relevance 0.88
The effect of PKC activation was abolished in the presence of bupivacaine.
Positive_regulation (activation) of PKC
13) Confidence 0.55 Published 2006 Journal Br J Anaesth Section Body Doc Link 16299047 Disease Relevance 0 Pain Relevance 0
While exposure to nicotine can result in the activation of the two major signalling pathways (MAP kinase and PKC) that are known to inhibit apoptosis, nicotine regulation of MAP (ERK2) kinase activity is not dependent on PKC.
Positive_regulation (activation) of PKC associated with kinase c, nicotine and apoptosis
14) Confidence 0.51 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 1.13 Pain Relevance 0.60
While exposure to nicotine can result in the activation of the two major signalling pathways (MAP kinase and PKC) that are known to inhibit apoptosis, nicotine regulation of MAP (ERK2) kinase activity is not dependent on PKC.
Neg (not) Positive_regulation (dependent) of PKC associated with kinase c, nicotine and apoptosis
15) Confidence 0.51 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 1.11 Pain Relevance 0.59
Bradykinin (BK) is an inflammatory mediator that plays a pivotal role in pain and hyperalgesia to heat in inflamed tissues by exciting nociceptors and sensitizing them to heat through activation of protein kinase C (PKC).
Positive_regulation (activation) of PKC in nociceptors associated with pain, kinase c, hyperalgesia, inflammation, nociceptor and bradykinin
16) Confidence 0.51 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12091579 Disease Relevance 0.29 Pain Relevance 1.04
In this series of experiments, we continue our investigation of how opioid-activated PKC contributes to homologous receptor down-regulation and then expand our focus to include the exploration of the mechanism(s) by which mu-opioids produce PKC translocation in SH-SY5Y neuroblastoma cells.
Spec (investigation) Positive_regulation (opioid-activated) of PKC in SH-SY5Y associated with neuroblastoma, kinase c and opioid
17) Confidence 0.50 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.09 Pain Relevance 1.10
Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: II.
Positive_regulation (Role) of PKC associated with kinase c, analgesic, agonist and opioid receptor
18) Confidence 0.50 Published 1999 Journal J. Neurochem. Section Title Doc Link 9930731 Disease Relevance 0.06 Pain Relevance 1.16
Our evidence suggests that direct PKC activation by mu-opioid agonists is involved in the processes that result in mu-receptor down-regulation in human neuroblastoma cells and that conventional, novel, and atypical PKC isozymes are involved.
Positive_regulation (activation) of PKC associated with neuroblastoma, mu agonist and kinase c
19) Confidence 0.50 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930731 Disease Relevance 0.10 Pain Relevance 1.18
On the other hand, when submitogenic Con A concentrations (1 microgram/ml) were used, fluoxetine stimulated the cellular response and increased PKC translocation.
Positive_regulation (increased) of PKC associated with kinase c and fluoxetine
20) Confidence 0.47 Published 1998 Journal Acta Physiol Pharmacol Ther Latinoam Section Abstract Doc Link 9914808 Disease Relevance 0.09 Pain Relevance 0.76

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