INT48720

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Context Info
Confidence 0.68
First Reported 1994
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.76
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1) extracellular region (SERPINE1) plasma membrane (SERPINE1)
Anatomy Link Frequency
fibroblasts 3
lymph node 2
egg 1
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 97.28 Very High Very High Very High
bDMF 21 95.16 Very High Very High Very High
palliative 6 95.16 Very High Very High Very High
Arthritis 3 90.40 High High
fibrosis 85 88.68 High High
cytokine 16 87.96 High High
Inflammatory mediators 2 86.96 High High
Inflammation 55 84.96 Quite High
Kinase C 2 82.72 Quite High
depression 3 74.04 Quite High
Disease Link Frequency Relevance Heat
Keloid Scars 12 99.40 Very High Very High Very High
Disease 159 99.36 Very High Very High Very High
Heart Rate Under Development 17 98.60 Very High Very High Very High
Breast Cancer 70 98.16 Very High Very High Very High
Hypertension 9 97.44 Very High Very High Very High
Necrosis 8 97.22 Very High Very High Very High
Cancer 75 97.04 Very High Very High Very High
Cardiovascular Disease 43 90.56 High High
Arthritis 3 90.40 High High
Pulmonary Fibrosis 63 88.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PGE2 reduced the rate of PAI-1 gene transcription as judged by run-off assays.
Transcription (transcription) of PAI-1 gene
1) Confidence 0.68 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0.17 Pain Relevance 0.26
Tumor necrosis factor alpha (TNF alpha) reduced, and transforming growth factor-beta (TGF-beta) and basic fibroblast growth factor (bFGF) increased, the levels of PAI-1 antigen and mRNA in the culture fluids and cell extracts, respectively.
Transcription (levels) of PAI-1 in fibroblast associated with necrosis and cancer
2) Confidence 0.64 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8054359 Disease Relevance 0.41 Pain Relevance 0.28
Prognostic significance of urokinase plasminogen activator and plasminogen activator inhibitor-1 mRNA expression in lymph node- and hormone receptor-positive breast cancer

Background

Transcription (expression) of plasminogen activator inhibitor-1 in lymph node associated with breast cancer
3) Confidence 0.53 Published 2006 Journal BMC Cancer Section Title Doc Link PMC1564186 Disease Relevance 0.58 Pain Relevance 0
To our knowledge, we are the first to evaluate the prognostic impact of uPA and PAI-1 at the mRNA level in a specific group of lymph node positive- and hormone receptor-positive breast cancers.
Transcription (level) of PAI-1 in lymph node associated with breast cancer
4) Confidence 0.53 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.87 Pain Relevance 0
Transcriptional regulation of plasminogen activator inhibitor-1 expression in human synovial fibroblasts by prostaglandin E2: mediation by protein kinase A and role of interleukin-1.
Transcription (Transcriptional) of plasminogen activator in fibroblasts
5) Confidence 0.52 Published 1994 Journal Mol. Cell. Endocrinol. Section Title Doc Link 7525383 Disease Relevance 0.26 Pain Relevance 0.20
Therefore, if the level of PAI-1 is high in the AD affected samples, plasminogen activators are being inhibited, resulting in decreased levels of mature BDNF.
Transcription (level) of PAI-1 associated with disease and bdmf
6) Confidence 0.52 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.63 Pain Relevance 0.59
Fig. 3 shows the mRNA levels of three of these genes (PAI1, THBS1, and IHH) in each of the 14 group B samples and the 14 group A samples.
Transcription (levels) of PAI1
7) Confidence 0.45 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.27 Pain Relevance 0.03
The Hastings PAI was in such a position, and had not been appropriated by the end of the interwar period.27 The pace of appropriation after 1930 shown in Figure 1 supports the Ministry's assertion that suitable buildings were appropriated rapidly, while the others lagged behind until improvements could be made, or reservations overcome.
Neg (not) Transcription (appropriated) of PAI
8) Confidence 0.34 Published 2006 Journal Medical History Section Body Doc Link PMC1369011 Disease Relevance 0.10 Pain Relevance 0.10
A borough councillor in Grimsby described the Scartho Road PAI as like the curate's egg, although the surveyor's notes suggest that the bad parts outweighed the good.
Transcription (described) of PAI in egg
9) Confidence 0.34 Published 2006 Journal Medical History Section Body Doc Link PMC1369011 Disease Relevance 0 Pain Relevance 0
In addition, fibroblasts might also play a role in excessive fibrin deposit; it was found recently that dermal fibroblasts derived from keloid lesions markedly overexpress PAI-1 mRNA transcripts and protein compared to normal skin fibroblasts.
Transcription (transcripts) of PAI-1 in fibroblasts associated with keloid scars
10) Confidence 0.13 Published 2002 Journal Respir Res Section Body Doc Link PMC64814 Disease Relevance 0.84 Pain Relevance 0.21
SREBP-1c enhances the transcription of the genes required for fatty acid synthesis and fatty acid elongation including fatty acids synthetase (FAS) and SCD (Pai et al 1998; K├Ânig et al 2008).
Transcription (transcription) of Pai
11) Confidence 0.04 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663461 Disease Relevance 0.62 Pain Relevance 0

General Comments

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