INT48721

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.40
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1) extracellular region (SERPINE1) plasma membrane (SERPINE1)
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 1 96.96 Very High Very High Very High
Inflammation 4 96.48 Very High Very High Very High
Inflammatory mediators 1 94.88 High High
Arthritis 1 90.92 High High
agonist 1 89.60 High High
Kinase C 1 64.88 Quite High
cva 6 56.24 Quite High
imagery 2 39.04 Quite Low
cINOD 1 25.00 Low Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 2 98.60 Very High Very High Very High
Cv Unclassified Under Development 3 96.96 Very High Very High Very High
INFLAMMATION 5 96.48 Very High Very High Very High
Disease 27 93.72 High High
Thrombosis 30 91.76 High High
Arthritis 1 90.92 High High
Cancer 28 87.28 High High
Hyperhomocysteinemia 2 74.16 Quite High
Myxoma 1 69.24 Quite High
Breast Cancer 34 63.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unfortunately, immunohistochemical assays of the uPA/PAI-1 system have provided unsatisfactory results mainly due to an absence of consensus regarding uPA and PAI-1 cellular localization [24].
Negative_regulation (absence) of Localization (localization) of PAI-1
1) Confidence 0.43 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.59 Pain Relevance 0
PGE2 (and PGE1) inhibited PAI-1 mRNA expression and secretion in a dose-dependent manner with an IC50 (for antigen secretion) of 4.6 x 10(-10) M and 8.7 x 10(-10) M, respectively.
Negative_regulation (inhibited) of Localization (secretion) of PAI-1 mRNA
2) Confidence 0.42 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0.28 Pain Relevance 0.22
Also decreased release of vascular tissue plasminogen activator has been reported in systemic and cutaneous vasculitis [12].
Negative_regulation (decreased) of Localization (release) of plasminogen activator associated with increased venous pressure under development
3) Confidence 0.05 Published 2005 Journal Thromb J Section Body Doc Link PMC1192821 Disease Relevance 1.52 Pain Relevance 0.16

General Comments

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