INT48725

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 128
Total Number 130
Disease Relevance 78.83
Pain Relevance 8.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGFBP3) extracellular region (IGFBP3) nucleus (IGFBP3)
Anatomy Link Frequency
plasma 5
blood 5
brain 4
fibroblasts 4
molar 3
IGFBP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 52 99.66 Very High Very High Very High
Inflammation 94 99.52 Very High Very High Very High
dexamethasone 11 99.42 Very High Very High Very High
Chronic pancreatitis 4 99.36 Very High Very High Very High
Fibrositis 14 99.28 Very High Very High Very High
Clonidine 22 99.20 Very High Very High Very High
Osteoarthritis 25 98.92 Very High Very High Very High
Arthritis 20 98.50 Very High Very High Very High
rheumatoid arthritis 245 98.08 Very High Very High Very High
interstitial cystitis 90 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 2107 100.00 Very High Very High Very High
Sprains And Strains 245 100.00 Very High Very High Very High
Cancer 420 99.84 Very High Very High Very High
Adhesions 650 99.68 Very High Very High Very High
Malignant Neoplastic Disease 160 99.68 Very High Very High Very High
INFLAMMATION 108 99.52 Very High Very High Very High
Metastasis 7 99.52 Very High Very High Very High
Adenoma 547 99.44 Very High Very High Very High
Disease 347 99.44 Very High Very High Very High
Pancreatitis 6 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The contribution of locally expressed IGFBP-3 to pre-malignant and malignant lesions in the colon is not well understood and few studies have evaluated tissue expression of IGFBP-3 in relation to cancer development and progression.
Gene_expression (expressed) of IGFBP-3 in colon associated with malignant neoplastic disease and cancer
1) Confidence 0.78 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.15 Pain Relevance 0.05
Other studies have shown that elevated IGFBP-3 expression is associated with reduced risk of gastric cancer [3] and prostate cancer [37].
Gene_expression (expression) of IGFBP-3 associated with reprotox - general 1 and stomach cancer
2) Confidence 0.78 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.08 Pain Relevance 0.03
The contribution of locally expressed IGFBP-3 to pre-malignant and malignant lesions in the colon is not well understood and few studies have evaluated tissue expression of IGFBP-3 in relation to cancer development and progression.
Gene_expression (expression) of IGFBP-3 in colon associated with malignant neoplastic disease and cancer
3) Confidence 0.78 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.21 Pain Relevance 0.04
In addition to regulating the bioavailability of plasma IGFs, IGFBP3 is expressed locally in most if not all tissues including the intestine [31].
Neg (not) Gene_expression (expressed) of IGFBP3 in intestine associated with bioavailability
4) Confidence 0.78 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.04 Pain Relevance 0.05
A total of 830 eligible subjects agreed to participate in the study of which 706 completed at least one questionnaire, 669 gave blood samples or biopsies or both. 580 had adequate RNA quantity and quality for IGFBP-3 gene expression analysis, and 461 had apoptosis data.
Gene_expression (expression) of IGFBP-3 gene in blood associated with apoptosis
5) Confidence 0.78 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 0.78 Pain Relevance 0.04
PF IGF levels, determined by RIA, were approximately 60% of paired serum levels, and PF levels of IGFBP-2 and IGFBP-3, determined by Western ligand blotting and RIA, respectively, were approximately half of their serum concentrations.
Spec (determined) Gene_expression (levels) of IGFBP-3
6) Confidence 0.74 Published 1994 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7525631 Disease Relevance 0.30 Pain Relevance 0.15
These authors, therefore, examined the relationship between cigarette smoke exposure and serum IGF-1, and IGFBP-3 levels.
Gene_expression (levels) of IGFBP-3
7) Confidence 0.72 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671651 Disease Relevance 1.31 Pain Relevance 0
These authors, therefore, examined the relationship between cigarette smoke exposure and serum IGF-1, and IGFBP-3 levels.
Gene_expression (levels) of IGFBP-3
8) Confidence 0.72 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669552 Disease Relevance 1.31 Pain Relevance 0
It is apparent now that higher proliferative and reduced apoptotic nature of adhesion fibroblasts in human as reported earlier [5] could also derive from altered expression of hMet1-e, CSPG2, S100A10, CSPG2, IGFBP3, and the Bfl-1 that inhibits p53-induced apoptosis and is induced by cytokines TNF-?
Gene_expression (expression) of IGFBP3 in fibroblasts associated with apoptosis, adhesions and cytokine
9) Confidence 0.70 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.78 Pain Relevance 0.14
Our data suggest that dexamethasone is unable to increase circulating IGF-I and IGFBP-3 levels in man in the absence of endogenous GH.
Gene_expression (levels) of IGFBP-3 associated with dexamethasone
10) Confidence 0.70 Published 2001 Journal J. Endocrinol. Invest. Section Abstract Doc Link 11817711 Disease Relevance 0.07 Pain Relevance 0.28
The normalized ratio for IGFBP3 abundance was calculated as the ratio of IGFBP-3/PBGD for each sample divided by the IGFBP-3/PBGD ratio of the calibrator.
Gene_expression (abundance) of IGFBP3
11) Confidence 0.68 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 0 Pain Relevance 0
Western immunoblotting of column effluent with IGFBP-3 antiserum revealed immunoreactive IGFBP-3 forms of 37-43 kDa (major) and 28 kDa (minor) in serum and almost exclusively the 28-kDa band in PF, suggesting that IGFBP-3 in PF may be proteolytically processed.
Gene_expression (processed) of IGFBP-3 in band
12) Confidence 0.64 Published 1994 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7525631 Disease Relevance 0.07 Pain Relevance 0.06
The CC genotype of the -202 A>C polymorphism of the IGFBP3 gene was associated with lower IGFBP-3 levels in both ethnic groups.
Gene_expression (levels) of IGFBP-3
13) Confidence 0.63 Published 2005 Journal Cancer Causes Control Section Abstract Doc Link 16215864 Disease Relevance 0.49 Pain Relevance 0.09
We studied the GH response to provocation by clonidine and glucagon, measured the circulating concentrations of insulin, IGF-I, IGF-binding protein-3 (IGFBP-3) and ferritin, and evaluated IGF-I generation after a single dose of GH (0.1 mg/kg per dose) in 15 prepubertal patients with thalassaemia, 15 age-matched children with constitutional short stature (CSS) (height standard deviation score less than -2, with normal GH response to provocation) and 11 children with isolated GH deficiency (GHD).
Gene_expression (concentrations) of IGFBP-3 associated with thalassemia, growth problems and clonidine
14) Confidence 0.62 Published 1998 Journal Eur. J. Endocrinol. Section Abstract Doc Link 9578506 Disease Relevance 0.58 Pain Relevance 0.16
We studied the GH response to provocation by clonidine and glucagon, measured the circulating concentrations of insulin, IGF-I, IGF-binding protein-3 (IGFBP-3) and ferritin, and evaluated IGF-I generation after a single dose of GH (0.1 mg/kg per dose) in 15 prepubertal patients with thalassaemia, 15 age-matched children with constitutional short stature (CSS) (height standard deviation score less than -2, with normal GH response to provocation) and 11 children with isolated GH deficiency (GHD).
Gene_expression (generation) of IGF-binding protein-3 associated with thalassemia, growth problems and clonidine
15) Confidence 0.62 Published 1998 Journal Eur. J. Endocrinol. Section Abstract Doc Link 9578506 Disease Relevance 0.59 Pain Relevance 0.17
We studied the GH response to provocation by clonidine and glucagon, measured the circulating concentrations of insulin, IGF-I, IGF-binding protein-3 (IGFBP-3) and ferritin, and evaluated IGF-I generation after a single dose of GH (0.1 mg/kg per dose) in 15 prepubertal patients with thalassaemia, 15 age-matched children with constitutional short stature (CSS) (height standard deviation score less than -2, with normal GH response to provocation) and 11 children with isolated GH deficiency (GHD).
Gene_expression (generation) of IGFBP-3 associated with thalassemia, growth problems and clonidine
16) Confidence 0.62 Published 1998 Journal Eur. J. Endocrinol. Section Abstract Doc Link 9578506 Disease Relevance 0.59 Pain Relevance 0.17
We studied the GH response to provocation by clonidine and glucagon, measured the circulating concentrations of insulin, IGF-I, IGF-binding protein-3 (IGFBP-3) and ferritin, and evaluated IGF-I generation after a single dose of GH (0.1 mg/kg per dose) in 15 prepubertal patients with thalassaemia, 15 age-matched children with constitutional short stature (CSS) (height standard deviation score less than -2, with normal GH response to provocation) and 11 children with isolated GH deficiency (GHD).
Gene_expression (concentrations) of IGF-binding protein-3 associated with thalassemia, growth problems and clonidine
17) Confidence 0.62 Published 1998 Journal Eur. J. Endocrinol. Section Abstract Doc Link 9578506 Disease Relevance 0.58 Pain Relevance 0.16
Therefore, tobacco smoking would not appear to be a major confounder of the reported clinical associations between IGF-1, IGFBP-3, or IGF-1/IGFBP-3 ratios and specific disease entities, including certain malignancies and vascular disease.


Gene_expression (ratios) of IGFBP-3 associated with nicotine addiction, increased venous pressure under development and disease
18) Confidence 0.62 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671651 Disease Relevance 0.96 Pain Relevance 0
IGFBP-3 concentrations were measured in duplicate by immunoassay (Quantikine IGFBP-3 Immunoassay, R&D Systems, Minneapolis, MN), using NSO-expressed recombinant human IGFBP-3 to generate the standard curve.
Gene_expression (expressed) of IGFBP-3 in NSO
19) Confidence 0.62 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671651 Disease Relevance 0.18 Pain Relevance 0
Therefore, tobacco smoking would not appear to be a major confounder of the reported clinical associations between IGF-1, IGFBP-3, or IGF-1/IGFBP-3 ratios and specific disease entities, including certain malignancies and vascular disease.


Gene_expression (ratios) of IGFBP-3 associated with nicotine addiction, increased venous pressure under development and disease
20) Confidence 0.62 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669552 Disease Relevance 0.96 Pain Relevance 0

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