INT48726

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Context Info
Confidence 0.67
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 9.45
Pain Relevance 3.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGFBP1) extracellular space (IGFBP1) extracellular region (IGFBP1)
Anatomy Link Frequency
decidua 3
liver 1
cartilage 1
brain 1
legs 1
IGFBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 7 99.84 Very High Very High Very High
cytokine 89 99.76 Very High Very High Very High
Pain 21 97.44 Very High Very High Very High
rheumatoid arthritis 154 95.92 Very High Very High Very High
Migraine 6 95.68 Very High Very High Very High
Bioavailability 2 95.44 Very High Very High Very High
headache 10 94.12 High High
Fibrositis 22 93.32 High High
Lasting pain 3 92.76 High High
anesthesia 50 92.64 High High
Disease Link Frequency Relevance Heat
Hyperglycemia 1 99.76 Very High Very High Very High
Critical Illness 15 99.72 Very High Very High Very High
Insulin Resistance 38 99.68 Very High Very High Very High
Osteoarthritis 16 98.72 Very High Very High Very High
Hyperinsulinism 14 98.68 Very High Very High Very High
Acromegaly 83 98.40 Very High Very High Very High
Infection 58 97.84 Very High Very High Very High
Pain 16 97.44 Very High Very High Very High
Liver Disease 5 97.00 Very High Very High Very High
Obesity 31 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This change in cell shape is associated with rearrangements in cellular architecture, the accumulation of glycogen and increased expression of prolactin (PRL) and insulin growth factor binding protein 1 (IGFBP-1) [4], [5], [6].
Gene_expression (expression) of IGFBP-1
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
This change in cell shape is associated with rearrangements in cellular architecture, the accumulation of glycogen and increased expression of prolactin (PRL) and insulin growth factor binding protein 1 (IGFBP-1) [4], [5], [6].
Gene_expression (expression) of insulin growth factor binding protein 1
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
Insulin-like growth factor binding protein-1 (IGFBP-1), produced in the liver [11,21], is an important regulator of free IGF-1.
Gene_expression (produced) of Insulin-like growth factor binding protein-1 in liver
3) Confidence 0.65 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.19 Pain Relevance 0.04
We hypothesize that hyperinsulinaemia which marks the early phase of insulin resistance could decrease IGFBP production.
Gene_expression (production) of IGFBP associated with hyperinsulinism and insulin resistance
4) Confidence 0.58 Published 2007 Journal BMC Endocr Disord Section Body Doc Link PMC2151943 Disease Relevance 1.37 Pain Relevance 0.05
1-induced suppression of IGFBP-1 is not SMAD-dependent and these data suggest that TGF?
Gene_expression (suppression) of IGFBP-1
5) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0.07
In contrast a significant decrease in the amount of IGFBP-1 protein released from the cells was detected after only 2 h incubation with TGF?
Gene_expression (protein) of IGFBP-1
6) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
1 reduces the expression and secretion of PRL, IGFBP-1, and TF by human ESCs decidualized in vitro, as well as primary DSCs obtained from 1st trimester decidua.
Gene_expression (expression) of IGFBP-1 in decidua
7) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
1 down-regulated the expression of IGFBP-1 mRNA in a time-dependent manner with a significant decrease observed at 48 h (p<0.01) and 72 h (p<0.001), as compared to time-matched controls (Figure 1A).
Gene_expression (expression) of IGFBP-1 mRNA
8) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
1 markedly inhibits the expression of PRL, IGFBP-1, and TF mRNAs in DSCs this inhibition was delayed by at least 24 h when compared to the response observed in ESC.
Gene_expression (expression) of IGFBP-1
9) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0.17 Pain Relevance 0.09
1 antibodies maintained expression of PRL mRNA (Figure 2A) and significantly potentiated expression of IGFBP-1 mRNA in comparison with ESCs treated with DM alone (p<0.001, Figure 2B).


Gene_expression (expression) of IGFBP-1 mRNA
10) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
1 increased expression of IGFBP-1 mRNA in decidualised cells.
Gene_expression (expression) of IGFBP-1 mRNA
11) Confidence 0.52 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
1 on expression of PRL in ESCs but did not fully restore expression of IGFBP-1 mRNA and protein.


Gene_expression (expression) of IGFBP-1 mRNA
12) Confidence 0.52 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
Fasting levels of IGF-1, Insulin-like growth factor binding protein-1 (IGFBP-1), insulin and P-glucose were studied prior to, and four days following, operation.
Gene_expression (levels) of Insulin-like growth factor binding protein-1
13) Confidence 0.51 Published 2007 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC1779788 Disease Relevance 0.24 Pain Relevance 0.35
IGFBP-4 was barely detectable by Western ligand blotting in PF, and levels of IGFBP-1, determined by immunoassay, were not appreciably different in PF and serum.
Gene_expression (levels) of IGFBP-1
14) Confidence 0.48 Published 1994 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7525631 Disease Relevance 0.28 Pain Relevance 0.14
Critically ill patients have hyperglycemia and raised levels of insulin-like growth factor binding protein-1.
Gene_expression (levels) of insulin-like growth factor binding protein-1 associated with hyperglycemia and critical illness
15) Confidence 0.37 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012437 Disease Relevance 0.63 Pain Relevance 0.04
To gain further insight into the mechanisms leading to dysregulation of the GH-IGF-1 axis in these patients, we assessed 24-h spontaneous GH secretion, GH responses to GHRH, and IGF-1 and IGF binding protein (BP)-3 levels before and after 4 days treatment with human (h)GH.
Gene_expression (levels) of IGF binding protein
16) Confidence 0.29 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10487713 Disease Relevance 1.17 Pain Relevance 0.54
1 inhibited both IGFBP-1 and PRL production in a time-dependent manner in decidual cells from 1st trimester [26], [36] and term pregnancy [27].
Gene_expression (production) of IGFBP-1
17) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0.13 Pain Relevance 0.10
Similarly, cytokines upregulate IGFBP-1 synthesis [30].
Gene_expression (synthesis) of IGFBP-1 associated with cytokine
18) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 1.02 Pain Relevance 0.32
At baseline, IGFBP-I and IGFBP-III values were significantly higher in patients compared with healthy subjects at baseline (Table 2), whereas GHBP values in healthy subjects at baseline were almost double those in patients (P = 0ยท01).
Gene_expression (values) of IGFBP-I
19) Confidence 0.15 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0 Pain Relevance 0
Baseline levels of GH, insulin-like growth factor I, and insulin-like growth factor binding protein-1 were similar in the two groups of patients and the controls.
Gene_expression (levels) of insulin-like growth factor binding protein-1
20) Confidence 0.14 Published 2000 Journal Fertil. Steril. Section Body Doc Link 10632417 Disease Relevance 0 Pain Relevance 0

General Comments

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