INT4873

Context Info Confidence 0.49 First Reported 1992 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 21 Total Number 21 Disease Relevance 14.35 Pain Relevance 2.89

extracellular region (FCGR3A) plasma membrane (FCGR3A)

Anatomy Link Frequency platelet 2 plasma 1 macrophages 1 spike 1 intestines 1 FCGR3A (Homo sapiens)

Pain Link Frequency Relevance Heat Neuritis 12 98.88 Angina 6 97.60 Sciatic nerve 4 96.96 pain flank 3 92.60 Pain 4 91.36 ischemia 7 88.08 cytokine 16 86.72 headache 2 81.56 Spinal cord 2 80.60 Multiple sclerosis 4 76.68

Disease Link Frequency Relevance Heat Leukocytosis 1 99.66 Cancer 25 99.42 Coronary Artery Disease 24 99.28 Experimental Autoimmune Neuritis 12 98.88 Pathologic Constriction 11 98.04 Atherosclerosis 26 97.88 Residual Neoplasm 3 97.72 Cv General 3 Under Development 6 97.60 Disorder Of Lipid Metabolism 16 97.40 Disease 35 97.38

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Event

Anatomy

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Disease term

A group of 15 patients with refractory Hodgkin's disease were treated in a phase I/II trial with the natural-killer (NK)-cell-activating bispecific monoclonal antibody HRS-3/A9, which is directed against the Fc gamma receptor III (CD16 antigen) and the Hodgkin's associated CD30 antigen.

Positive_regulation (directed) of CD16 associated with disease

1) Confidence 0.49 Published 1997 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 9435869 Disease Relevance 0.41 Pain Relevance 0.08

Fifteen patients with refractory Hodgkin's disease were treated in a phase I/II trial with the natural killer (NK)-cell-activating bispecific monoclonal antibody HRS-3/A9, which is directed against the Fc(gamma)-receptor III (CD16 antigen) and the Hodgkin's-associated CD30 antigen, respectively.

Positive_regulation (directed) of CD16 associated with disease

2) Confidence 0.49 Published 1997 Journal Blood Section Abstract Doc Link 9058726 Disease Relevance 0.35 Pain Relevance 0.06

We confirmed our microarrays findings by Real time PCR on selected upregulated genes such as Lactoferrin Lipocalin, S100P, FCGR3A, and TLR2 (Figure 2).

Positive_regulation (upregulated) of FCGR3A

3) Confidence 0.47 Published 2005 Journal BMC Immunol Section Body Doc Link PMC546205 Disease Relevance 0.30 Pain Relevance 0.13

Increased soluble FcgammaRIIIa(Mphi) in plasma from patients with coronary artery diseases.

Positive_regulation (Increased) of FcgammaRIIIa in plasma associated with coronary artery disease

4) Confidence 0.45 Published 2006 Journal Atherosclerosis Section Title Doc Link 16310791 Disease Relevance 0.69 Pain Relevance 0.06

The sFc gamma RIIIaM phi level was significantly increased in patients with coronary artery disease (CAD) with atherosclerosis, but not in patients with vasospastic angina (VSA) or intact coronary artery, compared with age-matched healthy donors.

Neg (not) Positive_regulation (increased) of sFc gamma RIIIaM phi in coronary artery associated with angina, coronary artery disease and atherosclerosis

5) Confidence 0.44 Published 2003 Journal Rinsho Byori Section Abstract Doc Link 14679789 Disease Relevance 1.01 Pain Relevance 0.10

In healthy donors, the level of sFc gamma RIIIaM phi increased with age, and was positively correlated with LDL-cholesterol to HDL-cholesterol ratios and LDL-cholesterol, but negatively with HDL-cholesterol.

Positive_regulation (increased) of sFc gamma RIIIaM phi associated with disorder of lipid metabolism

6) Confidence 0.44 Published 2003 Journal Rinsho Byori Section Abstract Doc Link 14679789 Disease Relevance 0.61 Pain Relevance 0.06

The RIII reflex threshold was found to increase during stage 2 of NREM sleep.

Positive_regulation (increase) of RIII

7) Confidence 0.44 Published 2001 Journal Sleep Section Abstract Doc Link 11204048 Disease Relevance 0.25 Pain Relevance 0

The level of sFcgammaRIIIa(Mphi), as well as the level of sFcgammaRIIIa (sFcgammaRIIIa(Mphi) plus sFcgammaRIIIa(NK)) or the level of total sFcgammaRIII (sFcgammaRIIIa plus sFcgammaRIIIb), were significantly increased in patients with CAD, but not in patients with vasospastic angina (VSA) or intact coronary arteries, compared with age-matched healthy donors.

Positive_regulation (increased) of sFcgammaRIIIa associated with angina and coronary artery disease

8) Confidence 0.40 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16310791 Disease Relevance 0.86 Pain Relevance 0.10

The level of sFcgammaRIIIa(Mphi), as well as the level of sFcgammaRIIIa (sFcgammaRIIIa(Mphi) plus sFcgammaRIIIa(NK)) or the level of total sFcgammaRIII (sFcgammaRIIIa plus sFcgammaRIIIb), were significantly increased in patients with CAD, but not in patients with vasospastic angina (VSA) or intact coronary arteries, compared with age-matched healthy donors.

Positive_regulation (increased) of sFcgammaRIII associated with angina and coronary artery disease

9) Confidence 0.37 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16310791 Disease Relevance 0.84 Pain Relevance 0.10

The level of sFcgammaRIIIa(Mphi), as well as the level of sFcgammaRIIIa (sFcgammaRIIIa(Mphi) plus sFcgammaRIIIa(NK)) or the level of total sFcgammaRIII (sFcgammaRIIIa plus sFcgammaRIIIb), were significantly increased in patients with CAD, but not in patients with vasospastic angina (VSA) or intact coronary arteries, compared with age-matched healthy donors.

Positive_regulation (increased) of sFcgammaRIIIa associated with angina and coronary artery disease

10) Confidence 0.37 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16310791 Disease Relevance 0.85 Pain Relevance 0.10

Interestingly the concomitant increase of CD16:2/CLA and DIN/IP ratios are suggestive of an increased peroxisomal beta oxidation as a physiological response to oxidative stress resulting in a decrease of PUFAHP and IP 2 hours after reperfusion.

Positive_regulation (increase) of CD16 associated with stress

11) Confidence 0.33 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2874547 Disease Relevance 0.54 Pain Relevance 0.12

A group of 15 patients with refractory Hodgkin's disease were treated in a phase I/II trial with the natural-killer (NK)-cell-activating bispecific monoclonal antibody HRS-3/A9, which is directed against the Fc gamma receptor III (CD16 antigen) and the Hodgkin's associated CD30 antigen.

Positive_regulation (directed) of receptor III associated with disease

12) Confidence 0.31 Published 1997 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 9435869 Disease Relevance 0.40 Pain Relevance 0.08

Pleocytosis (83/microl) and increase of protein (1269 mg/dl) and IgG (141 mg/dl) in the CSF were observed.

Positive_regulation (increase) of IgG associated with leukocytosis

13) Confidence 0.20 Published 2006 Journal Rinsho Shinkeigaku Section Abstract Doc Link 16768091 Disease Relevance 1.34 Pain Relevance 0.08

Immunoelectrophoresis showed an elevation of serum IgG level and a spike of M-protein was detected in the serum protein electrophoresis.

Positive_regulation (elevation) of IgG in spike

14) Confidence 0.15 Published 1993 Journal Hinyokika Kiyo Section Abstract Doc Link 8362683 Disease Relevance 0.95 Pain Relevance 0.09

CSF examination showed elevation of IgG index (1.6), three oligoclonal bands and myelin basic protein content of 2.4 ng/ml.

Positive_regulation (elevation) of IgG in bands

15) Confidence 0.12 Published 1993 Journal Rinsho Shinkeigaku Section Abstract Doc Link 8370208 Disease Relevance 0.67 Pain Relevance 0.30

Rapid tumor spreading in addition to re-elevation of the serum IgG level, however, developed after the 11th postoperative chemotherapy, which extensively involved the stomach and intestines.

Positive_regulation (elevation) of IgG in intestines associated with cancer

16) Confidence 0.10 Published 1993 Journal Hinyokika Kiyo Section Abstract Doc Link 8362683 Disease Relevance 0.91 Pain Relevance 0.06

Rapid tumor spreading in addition to re-elevation of the serum IgG level, however, developed after the 11th postoperative chemotherapy, which extensively involved the stomach and intestines.

Positive_regulation (elevation) of IgG in stomach associated with cancer

17) Confidence 0.04 Published 1993 Journal Hinyokika Kiyo Section Abstract Doc Link 8362683 Disease Relevance 0.91 Pain Relevance 0.06

Fc gamma R mRNA, which encodes Fc gamma RIII, an immunoglobulin-binding protein mediating activation of natural killer cells and macrophages by immune complexes, was transiently, but markedly induced in scattered endoneural cells, presumably macrophages, in cauda equina and sciatic nerves during the period of increasing weakness.

Positive_regulation (induced) of Fc gamma R mRNA in macrophages associated with sciatic nerve

18) Confidence 0.03 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1281167 Disease Relevance 0.52 Pain Relevance 0.66

Both patients were confirmed to have strong oxaliplatin-induced IgG platelet-reactive antibodies.

Positive_regulation (induced) of IgG in platelet

19) Confidence 0.02 Published 2010 Journal J Hematol Oncol Section Abstract Doc Link PMC2859393 Disease Relevance 0.99 Pain Relevance 0

Both patients were confirmed to have oxaliplatin-dependent IgG platelet antibodies.

Positive_regulation (dependent) of IgG in platelet

20) Confidence 0.02 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2859393 Disease Relevance 0.42 Pain Relevance 0

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