INT4873

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Context Info
Confidence 0.49
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 14.35
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FCGR3A) plasma membrane (FCGR3A)
Anatomy Link Frequency
platelet 2
plasma 1
macrophages 1
spike 1
intestines 1
FCGR3A (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 12 98.88 Very High Very High Very High
Angina 6 97.60 Very High Very High Very High
Sciatic nerve 4 96.96 Very High Very High Very High
pain flank 3 92.60 High High
Pain 4 91.36 High High
ischemia 7 88.08 High High
cytokine 16 86.72 High High
headache 2 81.56 Quite High
Spinal cord 2 80.60 Quite High
Multiple sclerosis 4 76.68 Quite High
Disease Link Frequency Relevance Heat
Leukocytosis 1 99.66 Very High Very High Very High
Cancer 25 99.42 Very High Very High Very High
Coronary Artery Disease 24 99.28 Very High Very High Very High
Experimental Autoimmune Neuritis 12 98.88 Very High Very High Very High
Pathologic Constriction 11 98.04 Very High Very High Very High
Atherosclerosis 26 97.88 Very High Very High Very High
Residual Neoplasm 3 97.72 Very High Very High Very High
Cv General 3 Under Development 6 97.60 Very High Very High Very High
Disorder Of Lipid Metabolism 16 97.40 Very High Very High Very High
Disease 35 97.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A group of 15 patients with refractory Hodgkin's disease were treated in a phase I/II trial with the natural-killer (NK)-cell-activating bispecific monoclonal antibody HRS-3/A9, which is directed against the Fc gamma receptor III (CD16 antigen) and the Hodgkin's associated CD30 antigen.
Positive_regulation (directed) of CD16 associated with disease
1) Confidence 0.49 Published 1997 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 9435869 Disease Relevance 0.41 Pain Relevance 0.08
Fifteen patients with refractory Hodgkin's disease were treated in a phase I/II trial with the natural killer (NK)-cell-activating bispecific monoclonal antibody HRS-3/A9, which is directed against the Fc(gamma)-receptor III (CD16 antigen) and the Hodgkin's-associated CD30 antigen, respectively.
Positive_regulation (directed) of CD16 associated with disease
2) Confidence 0.49 Published 1997 Journal Blood Section Abstract Doc Link 9058726 Disease Relevance 0.35 Pain Relevance 0.06
We confirmed our microarrays findings by Real time PCR on selected upregulated genes such as Lactoferrin Lipocalin, S100P, FCGR3A, and TLR2 (Figure 2).
Positive_regulation (upregulated) of FCGR3A
3) Confidence 0.47 Published 2005 Journal BMC Immunol Section Body Doc Link PMC546205 Disease Relevance 0.30 Pain Relevance 0.13
Increased soluble FcgammaRIIIa(Mphi) in plasma from patients with coronary artery diseases.
Positive_regulation (Increased) of FcgammaRIIIa in plasma associated with coronary artery disease
4) Confidence 0.45 Published 2006 Journal Atherosclerosis Section Title Doc Link 16310791 Disease Relevance 0.69 Pain Relevance 0.06
The sFc gamma RIIIaM phi level was significantly increased in patients with coronary artery disease (CAD) with atherosclerosis, but not in patients with vasospastic angina (VSA) or intact coronary artery, compared with age-matched healthy donors.
Neg (not) Positive_regulation (increased) of sFc gamma RIIIaM phi in coronary artery associated with angina, coronary artery disease and atherosclerosis
5) Confidence 0.44 Published 2003 Journal Rinsho Byori Section Abstract Doc Link 14679789 Disease Relevance 1.01 Pain Relevance 0.10
In healthy donors, the level of sFc gamma RIIIaM phi increased with age, and was positively correlated with LDL-cholesterol to HDL-cholesterol ratios and LDL-cholesterol, but negatively with HDL-cholesterol.
Positive_regulation (increased) of sFc gamma RIIIaM phi associated with disorder of lipid metabolism
6) Confidence 0.44 Published 2003 Journal Rinsho Byori Section Abstract Doc Link 14679789 Disease Relevance 0.61 Pain Relevance 0.06
The RIII reflex threshold was found to increase during stage 2 of NREM sleep.
Positive_regulation (increase) of RIII
7) Confidence 0.44 Published 2001 Journal Sleep Section Abstract Doc Link 11204048 Disease Relevance 0.25 Pain Relevance 0
The level of sFcgammaRIIIa(Mphi), as well as the level of sFcgammaRIIIa (sFcgammaRIIIa(Mphi) plus sFcgammaRIIIa(NK)) or the level of total sFcgammaRIII (sFcgammaRIIIa plus sFcgammaRIIIb), were significantly increased in patients with CAD, but not in patients with vasospastic angina (VSA) or intact coronary arteries, compared with age-matched healthy donors.
Positive_regulation (increased) of sFcgammaRIIIa associated with angina and coronary artery disease
8) Confidence 0.40 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16310791 Disease Relevance 0.86 Pain Relevance 0.10
The level of sFcgammaRIIIa(Mphi), as well as the level of sFcgammaRIIIa (sFcgammaRIIIa(Mphi) plus sFcgammaRIIIa(NK)) or the level of total sFcgammaRIII (sFcgammaRIIIa plus sFcgammaRIIIb), were significantly increased in patients with CAD, but not in patients with vasospastic angina (VSA) or intact coronary arteries, compared with age-matched healthy donors.
Positive_regulation (increased) of sFcgammaRIII associated with angina and coronary artery disease
9) Confidence 0.37 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16310791 Disease Relevance 0.84 Pain Relevance 0.10
The level of sFcgammaRIIIa(Mphi), as well as the level of sFcgammaRIIIa (sFcgammaRIIIa(Mphi) plus sFcgammaRIIIa(NK)) or the level of total sFcgammaRIII (sFcgammaRIIIa plus sFcgammaRIIIb), were significantly increased in patients with CAD, but not in patients with vasospastic angina (VSA) or intact coronary arteries, compared with age-matched healthy donors.
Positive_regulation (increased) of sFcgammaRIIIa associated with angina and coronary artery disease
10) Confidence 0.37 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16310791 Disease Relevance 0.85 Pain Relevance 0.10
Interestingly the concomitant increase of CD16:2/CLA and DIN/IP ratios are suggestive of an increased peroxisomal beta oxidation as a physiological response to oxidative stress resulting in a decrease of PUFAHP and IP 2 hours after reperfusion.
Positive_regulation (increase) of CD16 associated with stress
11) Confidence 0.33 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2874547 Disease Relevance 0.54 Pain Relevance 0.12
A group of 15 patients with refractory Hodgkin's disease were treated in a phase I/II trial with the natural-killer (NK)-cell-activating bispecific monoclonal antibody HRS-3/A9, which is directed against the Fc gamma receptor III (CD16 antigen) and the Hodgkin's associated CD30 antigen.
Positive_regulation (directed) of receptor III associated with disease
12) Confidence 0.31 Published 1997 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 9435869 Disease Relevance 0.40 Pain Relevance 0.08
Pleocytosis (83/microl) and increase of protein (1269 mg/dl) and IgG (141 mg/dl) in the CSF were observed.
Positive_regulation (increase) of IgG associated with leukocytosis
13) Confidence 0.20 Published 2006 Journal Rinsho Shinkeigaku Section Abstract Doc Link 16768091 Disease Relevance 1.34 Pain Relevance 0.08
Immunoelectrophoresis showed an elevation of serum IgG level and a spike of M-protein was detected in the serum protein electrophoresis.
Positive_regulation (elevation) of IgG in spike
14) Confidence 0.15 Published 1993 Journal Hinyokika Kiyo Section Abstract Doc Link 8362683 Disease Relevance 0.95 Pain Relevance 0.09
CSF examination showed elevation of IgG index (1.6), three oligoclonal bands and myelin basic protein content of 2.4 ng/ml.
Positive_regulation (elevation) of IgG in bands
15) Confidence 0.12 Published 1993 Journal Rinsho Shinkeigaku Section Abstract Doc Link 8370208 Disease Relevance 0.67 Pain Relevance 0.30
Rapid tumor spreading in addition to re-elevation of the serum IgG level, however, developed after the 11th postoperative chemotherapy, which extensively involved the stomach and intestines.
Positive_regulation (elevation) of IgG in intestines associated with cancer
16) Confidence 0.10 Published 1993 Journal Hinyokika Kiyo Section Abstract Doc Link 8362683 Disease Relevance 0.91 Pain Relevance 0.06
Rapid tumor spreading in addition to re-elevation of the serum IgG level, however, developed after the 11th postoperative chemotherapy, which extensively involved the stomach and intestines.
Positive_regulation (elevation) of IgG in stomach associated with cancer
17) Confidence 0.04 Published 1993 Journal Hinyokika Kiyo Section Abstract Doc Link 8362683 Disease Relevance 0.91 Pain Relevance 0.06
Fc gamma R mRNA, which encodes Fc gamma RIII, an immunoglobulin-binding protein mediating activation of natural killer cells and macrophages by immune complexes, was transiently, but markedly induced in scattered endoneural cells, presumably macrophages, in cauda equina and sciatic nerves during the period of increasing weakness.
Positive_regulation (induced) of Fc gamma R mRNA in macrophages associated with sciatic nerve
18) Confidence 0.03 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1281167 Disease Relevance 0.52 Pain Relevance 0.66
Both patients were confirmed to have strong oxaliplatin-induced IgG platelet-reactive antibodies.
Positive_regulation (induced) of IgG in platelet
19) Confidence 0.02 Published 2010 Journal J Hematol Oncol Section Abstract Doc Link PMC2859393 Disease Relevance 0.99 Pain Relevance 0
Both patients were confirmed to have oxaliplatin-dependent IgG platelet antibodies.
Positive_regulation (dependent) of IgG in platelet
20) Confidence 0.02 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2859393 Disease Relevance 0.42 Pain Relevance 0

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