INT4873
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
A group of 15 patients with refractory Hodgkin's disease were treated in a phase I/II trial with the natural-killer (NK)-cell-activating bispecific monoclonal antibody HRS-3/A9, which is directed against the Fc gamma receptor III (CD16 antigen) and the Hodgkin's associated CD30 antigen. | |||||||||||||||
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Fifteen patients with refractory Hodgkin's disease were treated in a phase I/II trial with the natural killer (NK)-cell-activating bispecific monoclonal antibody HRS-3/A9, which is directed against the Fc(gamma)-receptor III (CD16 antigen) and the Hodgkin's-associated CD30 antigen, respectively. | |||||||||||||||
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We confirmed our microarrays findings by Real time PCR on selected upregulated genes such as Lactoferrin Lipocalin, S100P, FCGR3A, and TLR2 (Figure 2). | |||||||||||||||
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Increased soluble FcgammaRIIIa(Mphi) in plasma from patients with coronary artery diseases. | |||||||||||||||
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The sFc gamma RIIIaM phi level was significantly increased in patients with coronary artery disease (CAD) with atherosclerosis, but not in patients with vasospastic angina (VSA) or intact coronary artery, compared with age-matched healthy donors. | |||||||||||||||
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In healthy donors, the level of sFc gamma RIIIaM phi increased with age, and was positively correlated with LDL-cholesterol to HDL-cholesterol ratios and LDL-cholesterol, but negatively with HDL-cholesterol. | |||||||||||||||
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The RIII reflex threshold was found to increase during stage 2 of NREM sleep. | |||||||||||||||
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The level of sFcgammaRIIIa(Mphi), as well as the level of sFcgammaRIIIa (sFcgammaRIIIa(Mphi) plus sFcgammaRIIIa(NK)) or the level of total sFcgammaRIII (sFcgammaRIIIa plus sFcgammaRIIIb), were significantly increased in patients with CAD, but not in patients with vasospastic angina (VSA) or intact coronary arteries, compared with age-matched healthy donors. | |||||||||||||||
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The level of sFcgammaRIIIa(Mphi), as well as the level of sFcgammaRIIIa (sFcgammaRIIIa(Mphi) plus sFcgammaRIIIa(NK)) or the level of total sFcgammaRIII (sFcgammaRIIIa plus sFcgammaRIIIb), were significantly increased in patients with CAD, but not in patients with vasospastic angina (VSA) or intact coronary arteries, compared with age-matched healthy donors. | |||||||||||||||
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The level of sFcgammaRIIIa(Mphi), as well as the level of sFcgammaRIIIa (sFcgammaRIIIa(Mphi) plus sFcgammaRIIIa(NK)) or the level of total sFcgammaRIII (sFcgammaRIIIa plus sFcgammaRIIIb), were significantly increased in patients with CAD, but not in patients with vasospastic angina (VSA) or intact coronary arteries, compared with age-matched healthy donors. | |||||||||||||||
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Interestingly the concomitant increase of CD16:2/CLA and DIN/IP ratios are suggestive of an increased peroxisomal beta oxidation as a physiological response to oxidative stress resulting in a decrease of PUFAHP and IP 2 hours after reperfusion. | |||||||||||||||
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A group of 15 patients with refractory Hodgkin's disease were treated in a phase I/II trial with the natural-killer (NK)-cell-activating bispecific monoclonal antibody HRS-3/A9, which is directed against the Fc gamma receptor III (CD16 antigen) and the Hodgkin's associated CD30 antigen. | |||||||||||||||
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Pleocytosis (83/microl) and increase of protein (1269 mg/dl) and IgG (141 mg/dl) in the CSF were observed. | |||||||||||||||
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Immunoelectrophoresis showed an elevation of serum IgG level and a spike of M-protein was detected in the serum protein electrophoresis. | |||||||||||||||
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CSF examination showed elevation of IgG index (1.6), three oligoclonal bands and myelin basic protein content of 2.4 ng/ml. | |||||||||||||||
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Rapid tumor spreading in addition to re-elevation of the serum IgG level, however, developed after the 11th postoperative chemotherapy, which extensively involved the stomach and intestines. | |||||||||||||||
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Rapid tumor spreading in addition to re-elevation of the serum IgG level, however, developed after the 11th postoperative chemotherapy, which extensively involved the stomach and intestines. | |||||||||||||||
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Fc gamma R mRNA, which encodes Fc gamma RIII, an immunoglobulin-binding protein mediating activation of natural killer cells and macrophages by immune complexes, was transiently, but markedly induced in scattered endoneural cells, presumably macrophages, in cauda equina and sciatic nerves during the period of increasing weakness. | |||||||||||||||
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Both patients were confirmed to have strong oxaliplatin-induced IgG platelet-reactive antibodies. | |||||||||||||||
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Both patients were confirmed to have oxaliplatin-dependent IgG platelet antibodies. | |||||||||||||||
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