INT48750

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Context Info
Confidence 0.29
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.10
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nqo1) oxidoreductase activity (Nqo1) aging (Nqo1)
cytoplasm (Nqo1)
Anatomy Link Frequency
spinal cord 1
striated muscle 1
Nqo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 17 99.90 Very High Very High Very High
Spinal cord 4 99.68 Very High Very High Very High
Pain 2 99.50 Very High Very High Very High
Enkephalin 4 98.26 Very High Very High Very High
Neuropeptide 5 97.94 Very High Very High Very High
Dorsal horn 4 89.20 High High
medulla 1 86.96 High High
gABA 3 86.40 High High
Calcitonin gene-related peptide 2 82.24 Quite High
GABAergic 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Myalgia 1 99.50 Very High Very High Very High
Alcoholic Pancreatitis 3 50.00 Quite Low
Pancreatitis 3 42.68 Quite Low
Nociception 1 29.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No association of NADPH-diaphorase-positive nerve fibers with motor endplates was found in other organs containing striated muscle.
NADPH-diaphorase Neg (No) Binding (association) of in striated muscle
1) Confidence 0.29 Published 1994 Journal Cell Tissue Res. Section Abstract Doc Link 8187163 Disease Relevance 0 Pain Relevance 0.21
By combining immunofluorescent detection of neuropeptide Y or enkephalin with NADPH diaphorase histochemistry, we showed that peptide-immunoreactivity did not coexist with NADPH diaphorase.
diaphorase Neg (not) Binding (coexist) of associated with neuropeptide and enkephalin
2) Confidence 0.25 Published 1994 Journal Neuroscience Section Abstract Doc Link 7526265 Disease Relevance 0 Pain Relevance 0.75
We hypothesize that quinone metabolites or other reactive forms of capsaicin may bind covalently to NQO1 and thereby inhibit its activity, leading to production of ROS.
NQO1 Binding (bind) of associated with qutenza
3) Confidence 0.18 Published 2007 Journal Antioxid. Redox Signal. Section Abstract Doc Link 17979524 Disease Relevance 0 Pain Relevance 0.62
However, the gene deletion of GSTM1 and GSTT1, and the C-allele of NQO1 cannot be ruled out for association with alcoholism.


NQO1 Binding (association) of
4) Confidence 0.09 Published 2010 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 18986377 Disease Relevance 0 Pain Relevance 0
[Effect of muscle pain on c-fos expression and NADPH-diaphorase activity in the spinal cord].
NADPH-diaphorase Binding (activity) of in spinal cord associated with pain, qutenza, myalgia and spinal cord
5) Confidence 0.01 Published 2004 Journal Fiziol Zh Section Title Doc Link 15732761 Disease Relevance 0.10 Pain Relevance 0.73

General Comments

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