INT48757

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Context Info
Confidence 0.66
First Reported 1994
Last Reported 2004
Negated 1
Speculated 3
Reported most in Abstract
Documents 2
Total Number 5
Disease Relevance 1.50
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gap43)
Anatomy Link Frequency
Dorsal root ganglia 3
Merkel cells 1
Gap43 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 1 99.96 Very High Very High Very High
Calcitonin gene-related peptide 6 99.88 Very High Very High Very High
Eae 8 99.22 Very High Very High Very High
Neuropeptide 6 97.68 Very High Very High Very High
substance P 8 97.66 Very High Very High Very High
Hyperalgesia 3 94.92 High High
Morphine 5 84.00 Quite High
Neurotransmitter 2 78.60 Quite High
Neuropathic pain 2 75.00 Quite High
Sciatic nerve 2 51.76 Quite High
Disease Link Frequency Relevance Heat
Injury 8 99.22 Very High Very High Very High
Hyperalgesia 3 94.92 High High
Nervous System Injury 2 93.44 High High
Nociception 3 88.60 High High
Aids-related Complex 1 87.16 High High
Neuropathic Pain 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the exception of Gap43, the levels of Cltc, Gfap, Tau, stathmin, and alpha-tubulin proteins were found to be in good agreement with those from mRNA quantification.
Neg (exception) Transcription (exception) of Gap43
1) Confidence 0.66 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15199374 Disease Relevance 0.09 Pain Relevance 0.37
Dorsal root ganglia taken from animals with CCI were analyzed for alterations in mRNA levels encoding growth-associated protein-43 (GAP-43), calcitonin gene-related peptide (CGRP), galanin (GAL), neuropeptide Y (NPY), substance P (SP), and vasoactive intestinal polypeptide (VIP).
Spec (analyzed) Transcription (levels) of growth-associated protein-43 in Dorsal root ganglia associated with eae, neuropeptide, substance p and calcitonin gene-related peptide
2) Confidence 0.66 Published 1994 Journal Pain Section Abstract Doc Link 7526320 Disease Relevance 0.63 Pain Relevance 0.70
Dorsal root ganglia taken from animals with CCI were analyzed for alterations in mRNA levels encoding growth-associated protein-43 (GAP-43), calcitonin gene-related peptide (CGRP), galanin (GAL), neuropeptide Y (NPY), substance P (SP), and vasoactive intestinal polypeptide (VIP).
Spec (analyzed) Transcription (levels) of GAP-43 in Dorsal root ganglia associated with eae, neuropeptide, substance p and calcitonin gene-related peptide
3) Confidence 0.66 Published 1994 Journal Pain Section Abstract Doc Link 7526320 Disease Relevance 0.63 Pain Relevance 0.70
The relative amount of mRNA in a tissue sample concentrated in Merkel cells was compared semiquantitatively to that from nearby tissue without Merkel cells. mRNAs for VIP, tyrosine hydroxylase, substance P were found in higher concentration in Merkel cells than in control tissues. mRNA for genes encoding pro-enkephalin, GAP-43, CGRP, NGF and BDNF were detected in the Merkel cell samples at concentration statistically equivalent to those found in the control tissues.
Transcription (detected) of GAP-43 in Merkel cells associated with enkephalin and substance p
4) Confidence 0.55 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794495 Disease Relevance 0 Pain Relevance 0.27
The dorsal root ganglia (DRGs) were sampled at various times throughout the experiment and processed for in situ hybridization to examine mRNA expression of the NGF receptors (p75 and trkA) and GAP-43.
Spec (examine) Transcription (expression) of GAP-43 in DRGs
5) Confidence 0.39 Published 1998 Journal Exp. Neurol. Section Abstract Doc Link 9582251 Disease Relevance 0.16 Pain Relevance 0

General Comments

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