INT48761

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2008
Negated 0
Speculated 5
Reported most in Abstract
Documents 13
Total Number 18
Disease Relevance 8.53
Pain Relevance 8.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gal) Golgi apparatus (Gal) response to stress (Gal)
cytoplasm (Gal)
Anatomy Link Frequency
DRG 6
neurons 3
arcuate nucleus 1
sciatic nerve 1
lateral hypothalamic area 1
Gal (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 13 100.00 Very High Very High Very High
substance P 9 100.00 Very High Very High Very High
Somatostatin 4 100.00 Very High Very High Very High
Neuropeptide 33 99.92 Very High Very High Very High
dorsal root ganglion 30 99.88 Very High Very High Very High
Inflammation 10 99.72 Very High Very High Very High
Locus ceruleus 5 99.68 Very High Very High Very High
Sciatic nerve 16 99.32 Very High Very High Very High
Eae 11 99.22 Very High Very High Very High
gracile nuclei 1 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 34 99.88 Very High Very High Very High
INFLAMMATION 8 99.72 Very High Very High Very High
Injury 11 99.22 Very High Very High Very High
Sprains And Strains 22 99.00 Very High Very High Very High
Stress 3 97.80 Very High Very High Very High
Aids-related Complex 8 95.44 Very High Very High Very High
Neuropathic Pain 10 95.32 Very High Very High Very High
Sciatic Neuropathy 2 95.16 Very High Very High Very High
Hyperalgesia 2 94.92 High High
Nervous System Injury 9 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preprogalanin (GAL) mRNA expression in the locus coeruleus (LC) was positively correlated with mean distance run.
Transcription (expression) of GAL in locus coeruleus associated with locus ceruleus
1) Confidence 0.69 Published 2007 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 17368736 Disease Relevance 0 Pain Relevance 0.76
We examined galanin (GAL) mRNA expression in L4 and L5 dorsal root ganglion (DRG) neurons of adult rats after PSNL.
Spec (examined) Transcription (expression) of galanin in DRG associated with ganglion cysts and dorsal root ganglion
2) Confidence 0.69 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10218889 Disease Relevance 0.45 Pain Relevance 0.46
We examined galanin (GAL) mRNA expression in L4 and L5 dorsal root ganglion (DRG) neurons of adult rats after PSNL.
Spec (examined) Transcription (expression) of GAL in DRG associated with ganglion cysts and dorsal root ganglion
3) Confidence 0.69 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10218889 Disease Relevance 0.45 Pain Relevance 0.46
Dorsal root ganglia taken from animals with CCI were analyzed for alterations in mRNA levels encoding growth-associated protein-43 (GAP-43), calcitonin gene-related peptide (CGRP), galanin (GAL), neuropeptide Y (NPY), substance P (SP), and vasoactive intestinal polypeptide (VIP).
Spec (analyzed) Transcription (levels) of galanin in Dorsal root ganglia associated with eae, neuropeptide, substance p and calcitonin gene-related peptide
4) Confidence 0.67 Published 1994 Journal Pain Section Abstract Doc Link 7526320 Disease Relevance 0.63 Pain Relevance 0.71
Dorsal root ganglia taken from animals with CCI were analyzed for alterations in mRNA levels encoding growth-associated protein-43 (GAP-43), calcitonin gene-related peptide (CGRP), galanin (GAL), neuropeptide Y (NPY), substance P (SP), and vasoactive intestinal polypeptide (VIP).
Spec (analyzed) Transcription (levels) of GAL in Dorsal root ganglia associated with eae, neuropeptide, substance p and calcitonin gene-related peptide
5) Confidence 0.67 Published 1994 Journal Pain Section Abstract Doc Link 7526320 Disease Relevance 0.63 Pain Relevance 0.71
The level of GAL mRNA expression and the supernatant concentration of GAL in cultured IAST/GAL were significantly higher than those of IAST and IAST/Neo (P<0.01), but no significant differences were found between the IAST and IAST/Neo (P>0.05).
Transcription (expression) of GAL associated with sprains and strains
6) Confidence 0.52 Published 2005 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 16116957 Disease Relevance 1.85 Pain Relevance 0.07
Immunoreactive galanin, calcitonin gene-related peptide, substance P and somatostatin and their mRNAs were found in cell bodies in dorsal root ganglia of untreated monkeys and on the contralateral side of the monkeys with unilateral sciatic nerve lesion.
Transcription (found) of galanin in sciatic nerve associated with somatostatin, sciatic nerve, substance p and calcitonin gene-related peptide
7) Confidence 0.52 Published 1993 Journal J. Neurocytol. Section Abstract Doc Link 7686215 Disease Relevance 0.10 Pain Relevance 0.68
Using in situ hybridization, the expression of mRNA encoding galanin, vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), and nitric oxide synthase (NOS), respectively, was studied in lumbar dorsal root ganglia of rats given a single s.c. dose of 300 micrograms kg-1 resiniferatoxin (RTX), an ultrapotent capsaicin analogue.
Transcription (expression) of galanin in dorsal root ganglia associated with qutenza and neuropeptide
8) Confidence 0.52 Published 1995 Journal Neuroreport Section Abstract Doc Link 8595209 Disease Relevance 0 Pain Relevance 0.14
Since only 2-3% of neurons in the contralateral uninjured DRG were GAL mRNA positive, PSNL induced up-regulation of GAL mRNA in both injured and spared DRG neurons.
Transcription (positive) of GAL in DRG associated with dorsal root ganglion
9) Confidence 0.51 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10218889 Disease Relevance 0.60 Pain Relevance 0.45
Both galanin-R1 and galanin-R2 receptor mRNAs are expressed in rat DRGs, mainly in, respectively, large and small DRG neurons.
Transcription (expressed) of galanin in neurons associated with dorsal root ganglion
10) Confidence 0.48 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9928186 Disease Relevance 0.86 Pain Relevance 0.71
Both galanin-R1 and galanin-R2 receptor mRNAs are expressed in rat DRGs, mainly in, respectively, large and small DRG neurons.
Transcription (expressed) of galanin in neurons associated with dorsal root ganglion
11) Confidence 0.48 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9928186 Disease Relevance 0.86 Pain Relevance 0.71
Using combined retrograde fluorescent dye tracing and in situ hybridization, we found that 47% of the injured neurons and 10% of the spared neurons were GAL mRNA positive.
Transcription (positive) of GAL in neurons
12) Confidence 0.45 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10218889 Disease Relevance 0.42 Pain Relevance 0.45
There are about three Galanin receptors subtypes such as GalR1, GalR2 and GalR3, which belong to G-Protein coupled receptors, and the activity of galanin is modulated
Transcription (activity) of galanin
13) Confidence 0.43 Published 2006 Journal Bioinformation Section Body Doc Link PMC1891676 Disease Relevance 0.09 Pain Relevance 0.25
Neurones were subsequently visualised and hybridized for the mRNA of the galanin receptor Gal-R1.
Transcription (mRNA) of galanin
14) Confidence 0.41 Published 2003 Journal Neuroendocrinology Section Abstract Doc Link 12915763 Disease Relevance 0.28 Pain Relevance 0
Direct inhibitory action of galanin on hypothalamic arcuate nucleus neurones expressing galanin receptor Gal-r1 mRNA.
Transcription (expressing) of galanin in arcuate nucleus
15) Confidence 0.41 Published 2003 Journal Neuroendocrinology Section Title Doc Link 12915763 Disease Relevance 0.27 Pain Relevance 0.05
Galanin mRNA levels were upregulated by the combination of injection+swim stress in the saline- and the fluoxetine-treated groups in the LC, but not in the DR.
Transcription (levels) of Galanin associated with stress, locus ceruleus, raphe and fluoxetine
16) Confidence 0.40 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 18172432 Disease Relevance 0.45 Pain Relevance 1.06
However, no neuropeptide Y, galanin and calcitonin gene-related peptide messenger RNA was detected in the injured side gracile nuclei by in situ hybridization.
Transcription (detected) of galanin associated with gracile nuclei, neuropeptide and calcitonin gene-related peptide
17) Confidence 0.31 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430497 Disease Relevance 0.60 Pain Relevance 0.92
The expression and distribution of the mRNA coding for galanin precursor, preprogalanin (ppGAL), were analysed in several rat hypothalamic nuclei (periventricular, paraventricular, supraoptic, dorsomedial and arcuate nuclei and the lateral hypothalamic area) during development by an in situ hybridization technique and computer-assisted grain counting over individual cells. ppGAL mRNA (expressed as number of grains/100 microns2) was detectable from postnatal day (PD) 1 in all the nuclei considered, and the amount of transcript per cell was 6-11 times less than in the adult. ppGAL mRNA progressively increased from PD8 to 14 to 21.
Spec (analysed) Transcription (expression) of galanin precursor in lateral hypothalamic area
18) Confidence 0.11 Published 1995 Journal Eur. J. Neurosci. Section Abstract Doc Link 7542127 Disease Relevance 0 Pain Relevance 0

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