INT48766

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Context Info
Confidence 0.61
First Reported 1994
Last Reported 2011
Negated 5
Speculated 17
Reported most in Body
Documents 73
Total Number 90
Disease Relevance 37.01
Pain Relevance 24.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
neuronal 9
brain 4
pia mater 3
colon 3
neurons 3
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 125 100.00 Very High Very High Very High
agonist 117 100.00 Very High Very High Very High
5HT 58 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 36 100.00 Very High Very High Very High
Analgesic 35 100.00 Very High Very High Very High
nMDA receptor antagonist 31 100.00 Very High Very High Very High
Enkephalin 23 100.00 Very High Very High Very High
opioid receptor 9 100.00 Very High Very High Very High
Intracerebroventricular 5 100.00 Very High Very High Very High
Dopamine 54 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 653 100.00 Very High Very High Very High
Injury 295 100.00 Very High Very High Very High
Syndrome 34 100.00 Very High Very High Very High
Muscular Dystrophy 26 99.86 Very High Very High Very High
Schizophrenia 42 99.84 Very High Very High Very High
Hypoxia 36 99.80 Very High Very High Very High
Nociception 29 99.80 Very High Very High Very High
Glaucoma 107 99.68 Very High Very High Very High
Urological Neuroanatomy 22 99.52 Very High Very High Very High
Adult Respiratory Distress Syndrome 61 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we examined whether the vasoconstrictor response to hyperoxia is through activated adrenergic function (protocol 1) or through inhibitory effects on nitric oxide synthase (NOS) and/or cyclooxygenase (COX) (protocol 2).
Spec (whether) Regulation (effects) of nitric oxide synthase associated with hyperoxia
1) Confidence 0.61 Published 2007 Journal J. Appl. Physiol. Section Abstract Doc Link 17885027 Disease Relevance 0.41 Pain Relevance 0.17
In the present study we examined whether the vasoconstrictor response to hyperoxia is through activated adrenergic function (protocol 1) or through inhibitory effects on nitric oxide synthase (NOS) and/or cyclooxygenase (COX) (protocol 2).
Spec (whether) Regulation (effects) of NOS associated with hyperoxia
2) Confidence 0.61 Published 2007 Journal J. Appl. Physiol. Section Abstract Doc Link 17885027 Disease Relevance 0.41 Pain Relevance 0.17
Furthermore, L-arginine may have had a weak impact because the effect of NO occurred through up- or down regulation of the enzyme NOS and was not influenced by access to substrate.
Regulation (regulation) of NOS
3) Confidence 0.48 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC514546 Disease Relevance 0 Pain Relevance 0
Previous studies in animal models have suggested that there may be an inverse functional association between the two NOS isoforms within the vascular wall, with an up-regulation of nNOS when eNOS expression is reduced (Boulanger et al. 1998).
Regulation (regulation) of nNOS
4) Confidence 0.45 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.50 Pain Relevance 0.10
To explore the origin of diarrhea or constipation in human Duchenne muscular dystrophy (DMD), the effect of the inhibition of e- , i-, and n-nitric oxide synthase (NOS) on the motility of proximal and distal segments of colon of muscular dystrophy (mdx) and control mice was studied.
Regulation (effect) of n-nitric oxide synthase in colon associated with constipation, diarrhoea and muscular dystrophy
5) Confidence 0.43 Published 2004 Journal Jpn. J. Physiol. Section Abstract Doc Link 15760488 Disease Relevance 0.57 Pain Relevance 0
To explore the origin of diarrhea or constipation in human Duchenne muscular dystrophy (DMD), the effect of the inhibition of e- , i-, and n-nitric oxide synthase (NOS) on the motility of proximal and distal segments of colon of muscular dystrophy (mdx) and control mice was studied.
Regulation (effect) of NOS in colon associated with constipation, diarrhoea and muscular dystrophy
6) Confidence 0.43 Published 2004 Journal Jpn. J. Physiol. Section Abstract Doc Link 15760488 Disease Relevance 0.57 Pain Relevance 0
NOS activity, regulation of the production of cGMP
Regulation (regulation) of NOS
7) Confidence 0.41 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.51 Pain Relevance 0
of NOS regulation.
Regulation (regulation) of NOS
8) Confidence 0.41 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.38 Pain Relevance 0.07
(Ichihara et al. 1998) provided the first direct evidence for nNOS-dependent regulation of vascular tone in the kidney.
Regulation (regulation) of nNOS in kidney
9) Confidence 0.39 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.15 Pain Relevance 0.04
These local regulatory influences appear to be independent of any central actions of nNOS that affect autonomic function.
Neg (independent) Regulation (independent) of nNOS in autonomic
10) Confidence 0.39 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.06 Pain Relevance 0.18
The effect of the nitric oxide synthase inhibitor N-nitro-L-arginine-methyl ester on neuropeptide-induced vasodilation and protein extravasation in human skin.
Regulation (effect) of nitric oxide synthase in skin associated with nociceptor, neuropeptide and increased venous pressure under development
11) Confidence 0.39 Published 2003 Journal J. Vasc. Res. Section Title Doc Link 12808346 Disease Relevance 0.56 Pain Relevance 0.54
Therefore, further investigation to study the effect of tissue injury on NOS isoforms at earlier and latter time points is warranted.
Regulation (effect) of NOS associated with injury
12) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949722 Disease Relevance 0.67 Pain Relevance 0.56
Reference values for ROS and NOS, minimum safe concentrations or physiologically beneficial concentrations have yet not been defined.
Regulation (values) of NOS
13) Confidence 0.35 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 1.44 Pain Relevance 0
The up-regulations of NOS, ONOO-, and PAR protein were followed by a transient increase in protein contents of the pro-inflammatory IL-8 in the lung.
Regulation (regulations) of NOS in lung associated with inflammation
14) Confidence 0.34 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.57 Pain Relevance 0.16
All NOS isoforms are dependant on NADPH (?
Regulation (dependant) of NOS
15) Confidence 0.32 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.12 Pain Relevance 0.08
Very little is known, however, about the effect of NOS inhibitors on HPV in sepsis or pneumonia.
Regulation (effect) of NOS associated with papillomavirus infection, pneumonia and sepsis
16) Confidence 0.31 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721948 Disease Relevance 1.47 Pain Relevance 0.04
In the current study, striatal NO efflux was measured in anesthetized male rats using an NO-selective electrochemical microsensor and the role of DA in modulating NO synthase (NOS) activity was assessed during electrical or chemical (bicuculline) stimulation of the substantia nigra (SN).
Regulation (modulating) of NOS in substantia nigra associated with dopamine and substantia nigra
17) Confidence 0.31 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16012530 Disease Relevance 0 Pain Relevance 0.56
In the present study, we investigated in Wistar rats the effect of air stress on nitric oxide synthase (NOS) mRNA and protein expression in dura and pia mater using real-time polymerase chain reaction and Western blotting, respectively.
Spec (investigated) Regulation (effect) of NOS in pia mater associated with stress
18) Confidence 0.30 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396662 Disease Relevance 0.87 Pain Relevance 0.42
In the present study, we tested the effects of the non-selective nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine methyl ester (L-NAME) and the selective neuronal NOS inhibitor 7-nitro indazole (7-NI) and 6-nitro indazole (6-NI) on the chronic allodynia-like behavior.
Spec (like) Regulation (effects) of nitric oxide synthase in neuronal associated with allodynia
19) Confidence 0.29 Published 1996 Journal Pain Section Abstract Doc Link 8880855 Disease Relevance 0.81 Pain Relevance 0.87
In the present study, we tested the effects of the non-selective nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine methyl ester (L-NAME) and the selective neuronal NOS inhibitor 7-nitro indazole (7-NI) and 6-nitro indazole (6-NI) on the chronic allodynia-like behavior.
Spec (like) Regulation (effects) of NOS in neuronal associated with allodynia
20) Confidence 0.29 Published 1996 Journal Pain Section Abstract Doc Link 8880855 Disease Relevance 0.81 Pain Relevance 0.87

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