INT48767

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Context Info
Confidence 0.59
First Reported 1994
Last Reported 2011
Negated 8
Speculated 4
Reported most in Abstract
Documents 312
Total Number 321
Disease Relevance 154.25
Pain Relevance 90.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
neuronal 28
brain 12
nerve 10
neurons 9
lung 8
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 418 100.00 Very High Very High Very High
antagonist 400 100.00 Very High Very High Very High
nMDA receptor 281 100.00 Very High Very High Very High
withdrawal 217 100.00 Very High Very High Very High
Morphine 160 100.00 Very High Very High Very High
anesthesia 153 100.00 Very High Very High Very High
depression 145 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 66 100.00 Very High Very High Very High
Bioavailability 62 100.00 Very High Very High Very High
orphanin 15 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 128 100.00 Very High Very High Very High
Death 320 99.92 Very High Very High Very High
Pressure And Volume Under Development 209 99.92 Very High Very High Very High
INFLAMMATION 1605 99.90 Very High Very High Very High
Targeted Disruption 385 99.88 Very High Very High Very High
Drug Induced Neurotoxicity 102 99.88 Very High Very High Very High
Diabetes Mellitus 1505 99.86 Very High Very High Very High
Stress 1353 99.84 Very High Very High Very High
Sepsis 960 99.84 Very High Very High Very High
Injury 825 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we demonstrated that two nonselective inhibitors of nitric oxide synthase (NOS), L-NG-nitroarginine (L-NNA) and L-NG-nitroarginine methyl ester (L-NAME), reduced some signs of morphine withdrawal in rats.
Negative_regulation (inhibitors) of NOS associated with withdrawal and morphine
1) Confidence 0.59 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7568621 Disease Relevance 0.07 Pain Relevance 0.54
Previously, we demonstrated that two nonselective inhibitors of nitric oxide synthase (NOS), L-NG-nitroarginine (L-NNA) and L-NG-nitroarginine methyl ester (L-NAME), reduced some signs of morphine withdrawal in rats.
Negative_regulation (inhibitors) of nitric oxide synthase associated with withdrawal and morphine
2) Confidence 0.59 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7568621 Disease Relevance 0.07 Pain Relevance 0.54
NG monomethyl L-arginine ( L-NMMA:546C88) is an inhibitor of all three NO synthases (NOS), the enzymes that catalyse the production of NO.
Negative_regulation (inhibitor) of NOS
3) Confidence 0.58 Published 2003 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 13680036 Disease Relevance 0 Pain Relevance 0.09
Four inhibitors of nitric oxide synthase (NOS), administered as acute pretreatments, attenuated several signs of naloxone-precipitated opioid withdrawal in morphine-dependent rats.
Negative_regulation (inhibitors) of NOS associated with narcan, withdrawal, opioid and morphine
4) Confidence 0.58 Published 1995 Journal Neuropsychopharmacology Section Abstract Doc Link 8747756 Disease Relevance 0.31 Pain Relevance 0.79
Four inhibitors of nitric oxide synthase (NOS), administered as acute pretreatments, attenuated several signs of naloxone-precipitated opioid withdrawal in morphine-dependent rats.
Negative_regulation (inhibitors) of nitric oxide synthase associated with narcan, withdrawal, opioid and morphine
5) Confidence 0.58 Published 1995 Journal Neuropsychopharmacology Section Abstract Doc Link 8747756 Disease Relevance 0.31 Pain Relevance 0.79
Effects of selective inhibitors of neuronal nitric oxide synthase on carrageenan-induced mechanical and thermal hyperalgesia.
Negative_regulation (inhibitors) of nitric oxide synthase in neuronal associated with thermal hyperalgesia and neuronal nitric oxide synthase
6) Confidence 0.58 Published 1998 Journal Neuropharmacology Section Title Doc Link 9680257 Disease Relevance 0.59 Pain Relevance 0.42
The effect of inhibition of nitric oxide synthase (NOS) on hindpaw hyperalgesia (assessed using mechanical and thermal noxious stimuli) and oedema formation following intraplantar injection of carrageenan (150 microl, 2% w v(-1)) in the rat was determined.
Negative_regulation (inhibition) of nitric oxide synthase associated with pressure and volume under development and hyperalgesia
7) Confidence 0.58 Published 1998 Journal Neuropharmacology Section Abstract Doc Link 9680257 Disease Relevance 0.33 Pain Relevance 0.21
The effect of inhibition of nitric oxide synthase (NOS) on hindpaw hyperalgesia (assessed using mechanical and thermal noxious stimuli) and oedema formation following intraplantar injection of carrageenan (150 microl, 2% w v(-1)) in the rat was determined.
Negative_regulation (inhibition) of NOS associated with pressure and volume under development and hyperalgesia
8) Confidence 0.58 Published 1998 Journal Neuropharmacology Section Abstract Doc Link 9680257 Disease Relevance 0.33 Pain Relevance 0.21
Blockade of nitric oxide synthases (NOS) by L-nitromonomethylarginine effectively treats attacks of migraine without aura.
Negative_regulation (Blockade) of NOS associated with migraine
9) Confidence 0.57 Published 2010 Journal Neurotherapeutics Section Abstract Doc Link 20430317 Disease Relevance 1.17 Pain Relevance 1.08
Selective inhibition of nNOS decreased basal afferent and efferent arteriolar tone but had no effect on vasodilatation in response to the eNOS agonist acetylcholine.
Negative_regulation (inhibition) of nNOS associated with agonist and increased venous pressure under development
10) Confidence 0.51 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.16 Pain Relevance 0.05
The availability of a selective nNOS inhibitor validated for in vivo human use now paves the way for further direct investigation of some of these questions thereby to increase understanding of the roles of nNOS in human health and disease.



Negative_regulation (inhibitor) of nNOS associated with disease
11) Confidence 0.51 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.32 Pain Relevance 0.13
RESULTS: CMS deforms neurons in the hippocampal formation, and fluoxetine can renormalize the deformed neurons by inhibiting the nitric oxide synthase catalyzing the over-production of NO, which lead subsequently to the morphological abnormality in the circumscribed area of brain.
Negative_regulation (inhibiting) of nitric oxide synthase in neurons
12) Confidence 0.51 Published 2001 Journal Acta Pharmacol. Sin. Section Body Doc Link 11749766 Disease Relevance 0.16 Pain Relevance 0
In addition, ethylketocyclazocine, alpha(S1)-casomorphin and diprenorphine directly inhibit NOS activity: agonists, interact with both calcium-dependent and independent NOS-isoforms, while the antagonist diprenorphine modifies only the activity of the calcium-dependent fraction of the enzyme.
Negative_regulation (inhibit) of NOS associated with antagonist and agonist
13) Confidence 0.50 Published 2001 Journal Cell Death Differ. Section Abstract Doc Link 11526449 Disease Relevance 0.27 Pain Relevance 1.06
Most recently, a study of 36 male diabetic patients undergoing gastric resection showed significant loss of nNOS as well as SP expression; however, there was no information on whether these patients were symptomatic or had impaired gastric motility [20].
Negative_regulation (loss) of nNOS associated with diabetes mellitus and substance p
14) Confidence 0.48 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.75 Pain Relevance 0.20
In our patient with poorly controlled diabetes, the reduction in overall neuronal staining was accompanied by a significant loss of nNOS, but not SP expression, suggesting relatively specific injury to inhibitory neurons.
Negative_regulation (loss) of nNOS in neurons associated with diabetes mellitus, injury and substance p
15) Confidence 0.48 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.62 Pain Relevance 0.19
L-NAME, a nonselective inhibitor of nitric oxide synthase was injected 30 min before bacterial instillation in the PNA and PNANO groups.
Negative_regulation (inhibitor) of nitric oxide synthase
16) Confidence 0.47 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721948 Disease Relevance 0.41 Pain Relevance 0
These reports suggest that improvement of oxygenation with inhaled NO may be augmented by blockade of endogenous nitric oxide synthase (NOS) in the setting of increased NO synthesis in the lung, such as pneumonia (9) or sepsis (10).
Negative_regulation (blockade) of nitric oxide synthase in lung associated with pneumonia and sepsis
17) Confidence 0.47 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721948 Disease Relevance 1.36 Pain Relevance 0
These reports suggest that improvement of oxygenation with inhaled NO may be augmented by blockade of endogenous nitric oxide synthase (NOS) in the setting of increased NO synthesis in the lung, such as pneumonia (9) or sepsis (10).
Negative_regulation (blockade) of NOS in lung associated with pneumonia and sepsis
18) Confidence 0.47 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721948 Disease Relevance 1.36 Pain Relevance 0
We have previously demonstrated that inhibition of nitric oxide synthase (NOS) alters the toxicity of local anesthetics including bupivacaine.
Negative_regulation (inhibition) of NOS associated with toxicity and local anesthetic
19) Confidence 0.44 Published 2000 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 10899380 Disease Relevance 0.25 Pain Relevance 0.13
We have previously demonstrated that inhibition of nitric oxide synthase (NOS) alters the toxicity of local anesthetics including bupivacaine.
Negative_regulation (inhibition) of nitric oxide synthase associated with toxicity and local anesthetic
20) Confidence 0.44 Published 2000 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 10899380 Disease Relevance 0.25 Pain Relevance 0.13

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