INT48769

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Context Info
Confidence 0.35
First Reported 1994
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 20
Total Number 23
Disease Relevance 9.78
Pain Relevance 20.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1) plasma membrane (Pdpk1)
nucleus (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Anatomy Link Frequency
spinal cord 4
spinal 2
neurons 2
hindlimb 1
mesenteric artery 1
Pdpk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 97 100.00 Very High Very High Very High
Kinase C 52 100.00 Very High Very High Very High
narcan 23 100.00 Very High Very High Very High
nMDA receptor antagonist 12 100.00 Very High Very High Very High
nociceptor 14 99.96 Very High Very High Very High
withdrawal 62 99.90 Very High Very High Very High
substance P 13 99.88 Very High Very High Very High
Thermal hyperalgesia 20 99.76 Very High Very High Very High
Opioid 11 99.68 Very High Very High Very High
Morphine 42 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Opiate Addiction 3 99.90 Very High Very High Very High
Hyperalgesia 48 99.76 Very High Very High Very High
Diabetes Mellitus 8 99.58 Very High Very High Very High
Nociception 55 99.32 Very High Very High Very High
Injury 9 98.24 Very High Very High Very High
INFLAMMATION 38 97.68 Very High Very High Very High
Pain 164 96.04 Very High Very High Very High
Arthritis 126 95.80 Very High Very High Very High
Neuropathic Pain 65 94.56 High High
Morphine Dependence 2 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that central sensitization and persistent nociception following formalin-induced tissue injury, and the hyperalgesia in the formalin test induced by L-glutamate and substance P, are dependent on the intracellular messengers nitric oxide, arachidonic acid and protein kinase C.
Regulation (dependent) of protein kinase associated with nociception, kinase c, glutamate, hyperalgesia, central sensitization, injury and substance p
1) Confidence 0.35 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7526941 Disease Relevance 0.75 Pain Relevance 0.84
The contribution of the intracellular messengers nitric oxide, arachidonic acid and protein kinase C to persistent nociception in response to tissue injury in rats was examined following the subcutaneous injection of formalin into the hindpaw.
Spec (examined) Regulation (contribution) of protein kinase associated with nociception, kinase c and injury
2) Confidence 0.35 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7526941 Disease Relevance 0.60 Pain Relevance 0.42
In the present study, we examined the effect of intrathecal delivery of an antisense oligonucleotide targeting rat protein kinase Calpha mRNA on the expression of spinal protein kinase Calpha isozyme and spinal morphine tolerance.
Regulation (targeting) of protein kinase in spinal associated with tolerance, morphine and intrathecal
3) Confidence 0.32 Published 2002 Journal Neuroscience Section Abstract Doc Link 12123688 Disease Relevance 0 Pain Relevance 1.16
Agents that act by different mechanisms modulate the activity of protein kinase CbetaII isozyme in the rat spinal cord during peripheral inflammation.
Regulation (modulate) of protein kinase in spinal cord associated with inflammation and spinal cord
4) Confidence 0.23 Published 2006 Journal Neuroscience Section Title Doc Link 16360284 Disease Relevance 0.53 Pain Relevance 0.78
The role of glutamate in the locus coeruleus during opioid withdrawal and effects of H-7, a protein kinase inhibitor, on the action of glutamate in rats.
Regulation (effects) of protein kinase in locus coeruleus associated with glutamate, locus ceruleus, narcan, withdrawal and opioid
5) Confidence 0.22 Published 1998 Journal J. Biomed. Sci. Section Title Doc Link 9570513 Disease Relevance 0.25 Pain Relevance 1.86
This was accompanied by a significant increase in total functional membrane-associated protein kinase C activity, whereas total cytosolic protein kinase C activity was unchanged on the sides of the lumbar spinal cord both contralateral and ipsilateral to the inflammation.
Neg (unchanged) Regulation (unchanged) of protein kinase in spinal cord associated with kinase c, inflammation and spinal cord
6) Confidence 0.13 Published 2001 Journal Neuroscience Section Abstract Doc Link 11440817 Disease Relevance 0.94 Pain Relevance 1.23
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Neg (no) Regulation (effect) of protein kinase in spinal cord associated with spinal cord
7) Confidence 0.10 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.52 Pain Relevance 0.70
Protein kinase Cbeta antisense oligodeoxynucleotide had no significant effect on the membrane-associated activities of protein kinase Calpha and protein kinase Cgamma, but decreased the activities of both protein kinase CbetaI and protein kinase CbetaII and the expression of protein kinase Cbeta isozyme in the spinal cord.
Neg (no) Regulation (effect) of protein kinase in spinal cord associated with spinal cord
8) Confidence 0.10 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.52 Pain Relevance 0.70
The influence of an inhibitor of cAMP-dependent protein kinase and protein kinase C, H-7 [1-(5-isoquinolinesulfonyl)-2-methylpiperazine], on naloxone (an opioid receptor antagonist)-precipitated withdrawal signs and changes in levels of dopamine (DA) and its metabolites in morphine- or butorphanol-dependent rats was investigated.
Spec (investigated) Regulation (influence) of protein kinase associated with dopamine, narcan, opioid receptor, morphine, kinase c, antagonist, butorphanol and withdrawal
9) Confidence 0.10 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 10922515 Disease Relevance 0.07 Pain Relevance 1.12
The objective of the present study was to assess the influence of diabetes in the neuronal nitric oxide (NO) release elicited by electrical field stimulation (EFS, 200 mA, 0.3 ms, 1-16 Hz, for 30 s, at 1 min interval) in endothelium-denuded mesenteric artery segments from control and streptozotocin-induced diabetic rats, assessing the influence of protein kinase C (PKC) in this release.
Regulation (influence) of protein kinase in mesenteric artery associated with kinase c and diabetes mellitus
10) Confidence 0.09 Published 2000 Journal Life Sci. Section Abstract Doc Link 10665985 Disease Relevance 0.47 Pain Relevance 0.25
Collectively, the results are consistent with a role for spinal N-methyl-D-aspartate receptors, nitric oxide and protein kinase C in thermal hyperalgesia.
Regulation (role) of protein kinase in spinal associated with kinase c, thermal hyperalgesia and nmda receptor
11) Confidence 0.05 Published 1996 Journal Neuroscience Section Abstract Doc Link 9053788 Disease Relevance 0.68 Pain Relevance 1.04
Effects of the protein kinase A and C inhibitors on the DR-EPSP or the [Sar9,Met(O2)11]-SP-induced depolarization were nonadditive, suggesting convergence of these intracellular signalling pathways onto a common final target.
Regulation (Effects) of protein kinase
12) Confidence 0.05 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11553293 Disease Relevance 0.23 Pain Relevance 0.52
A role for protein kinase intracellular messengers in substance P- and nociceptor afferent-mediated excitation and expression of the transcription factor Fos in rat dorsal horn neurons in vitro.
Regulation (role) of protein kinase in nociceptor associated with nociceptor, dorsal horn neuron and substance p
13) Confidence 0.05 Published 2001 Journal Eur. J. Neurosci. Section Title Doc Link 11553293 Disease Relevance 0.25 Pain Relevance 0.62
A role for protein kinase C-dependent upregulation of adrenomedullin in the development of morphine tolerance in male rats.
Regulation (role) of protein kinase associated with kinase c, tolerance and morphine
14) Confidence 0.05 Published 2010 Journal J. Neurosci. Section Title Doc Link 20844145 Disease Relevance 0.37 Pain Relevance 1.25
In the present experiments, we studied (1) the possible role of protein kinases in the increased norepinephrine release occurring after naloxone injection and (2) the effects of NMDA receptor antagonists on chronic morphine exposure-induced changes in protein kinase activity.
Regulation (changes) of protein kinase associated with nmda receptor antagonist, narcan and morphine
15) Confidence 0.05 Published 1997 Journal J Toxicol Sci Section Abstract Doc Link 9076657 Disease Relevance 0.09 Pain Relevance 0.95
Effect of NMDA receptor antagonists on protein kinase activated by chronic morphine treatment.
Regulation (Effect) of protein kinase associated with nmda receptor antagonist, narcan and morphine
16) Confidence 0.05 Published 1997 Journal J Toxicol Sci Section Title Doc Link 9076657 Disease Relevance 0.09 Pain Relevance 1.06
The effectiveness of protein kinase inhibitors in the present study suggests tonic NMDA receptor phosphorylation in amygdala neurons in the arthritis pain state.
Regulation (effectiveness) of protein kinase in neurons associated with pain, nmda receptor, amygdala and arthritis
17) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.51 Pain Relevance 1.16
To validate the significance of the electrophysiological results, we analyzed the effects of protein kinase inhibitors on supraspinally (vocalizations) and spinally (hindlimb withdrawal reflexes) organized pain behaviors in awake animals (Figures 8, 9, 10).
Spec (analyzed) Regulation (effects) of protein kinase in hindlimb associated with pain and withdrawal
18) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.58 Pain Relevance 0.59
Finally, the differential effects of cannabinoids on I(A) and I(D) were both shown to be mediated via the well documented cannabinoid receptor inhibition of adenylyl cyclase and subsequent modulation of cAMP and protein kinase.
Regulation (modulation) of protein kinase associated with cannabinoid receptor and cannabinoid
19) Confidence 0.03 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10525114 Disease Relevance 0.08 Pain Relevance 0.34
Protein kinase B (PKB/Akt) is a member of the second-messenger regulated subfamily of protein kinases.
Regulation (regulated) of kinase B
20) Confidence 0.03 Published 2007 Journal Neuroscience Section Abstract Doc Link 17084039 Disease Relevance 0.36 Pain Relevance 0.42

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