INT4877

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2010
Negated 7
Speculated 2
Reported most in Body
Documents 184
Total Number 186
Disease Relevance 122.82
Pain Relevance 24.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MME) plasma membrane (MME) cell-cell signaling (MME)
Anatomy Link Frequency
spermatozoa 18
epithelial cells 8
lymph node 7
HUP-T3 6
HUP-T4 6
MME (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 508 100.00 Very High Very High Very High
Enkephalin 195 100.00 Very High Very High Very High
cytokine 97 100.00 Very High Very High Very High
Neuropeptide 62 100.00 Very High Very High Very High
Neuropathic pain 56 100.00 Very High Very High Very High
Somatostatin 2 100.00 Very High Very High Very High
antidepressant 5 99.96 Very High Very High Very High
Chronic pancreatitis 24 99.92 Very High Very High Very High
Catecholamine 1 99.76 Very High Very High Very High
diabetic neuropathy 8 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 5588 100.00 Very High Very High Very High
Leukemia 87 100.00 Very High Very High Very High
Neuropathic Pain 60 100.00 Very High Very High Very High
Syndrome 54 100.00 Very High Very High Very High
Prostate Cancer 1253 99.98 Very High Very High Very High
Diffuse Large B-cell Lymphoma 172 99.98 Very High Very High Very High
Follicular Lymphoma 69 99.96 Very High Very High Very High
Pancreatitis 52 99.92 Very High Very High Very High
B-cell Lymphoma 82 99.88 Very High Very High Very High
Renal Cancer 976 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data show that NEP and NEP2, the most important enzymes involved in tachykinin metabolism, are expressed in human sperm at both mRNA and protein levels.
Gene_expression (expressed) of NEP in sperm
1) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2936315 Disease Relevance 0.06 Pain Relevance 0.03
Our data show that NEP and NEP2, the most important enzymes involved in tachykinin metabolism, are expressed in human sperm at both mRNA and protein levels.
Gene_expression (expressed) of NEP2 in sperm
2) Confidence 0.78 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2936315 Disease Relevance 0.06 Pain Relevance 0.03
The expression of the housekeeping genes, DPP4 and MME was quantified in all cDNAs by real-time PCR using the iCycler iQ real-time detection apparatus (BioRad Laboratories, Hercules, CA, USA).
Gene_expression (expression) of MME
3) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.15 Pain Relevance 0
Quantitation of DPP IV and NEP mRNA expression
Gene_expression (expression) of NEP mRNA
4) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.15 Pain Relevance 0
These results agree with previous studies indicating that modifications in the activity and expression profiles of DPP IV and NEP are key events in malignant tumors, pointing to an involvement of these proteins in tumor cell growth, local invasion and metastasis [7,25-27]; and, in addition, this study extend that role of both peptidases to the renal tumors.
Gene_expression (expression) of NEP associated with malignant neoplastic disease, cancer, renal cancer and metastasis
5) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.84 Pain Relevance 0
Quantitative DPP IV and NEP expression profile in renal tumors
Gene_expression (expression) of NEP associated with renal cancer
6) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.42 Pain Relevance 0
Furthermore, we present evidence suggesting that the individual variations seen in immunocytes from both different and the same donors to activating substances may reflect fluctuating levels of NEP expressed in response to endogenous stimuli.
Gene_expression (expressed) of NEP
7) Confidence 0.77 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1281168 Disease Relevance 0.30 Pain Relevance 0.35
This group found that complete loss of CD10 expression was associated with PSA recurrence after RP.
Gene_expression (expression) of CD10 associated with recurrence
8) Confidence 0.77 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.38 Pain Relevance 0
CD10 expression is greater in more advanced primary melanomas and is upregulated in metastatic lesions compared with the corresponding primary tumors [5,6].
Gene_expression (expression) of CD10 associated with cancer and melanoma
9) Confidence 0.77 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.11 Pain Relevance 0.11
CD10 expression patterns in the Osman study were not reported by specific Gleason pattern within individual tumors which makes our studies difficult to compare.
Gene_expression (expression) of CD10 associated with cancer
10) Confidence 0.77 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.06 Pain Relevance 0
As can be seen, the expression pattern was similar for CD13 and CD10 (except in the cancer cell lines) with both CD10 and CD13 expression down-regulated in cancer specimens.
Gene_expression (expression) of CD10 associated with cancer
11) Confidence 0.77 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.41 Pain Relevance 0
Given the generally low Ki67 reactivity in prostate cancer [20] we are not sure how to interpret these data regarding lower CD10 expression in areas of apparent high proliferative activity.
Gene_expression (expression) of CD10 associated with prostate cancer
12) Confidence 0.77 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.28 Pain Relevance 0
In contrast to our results, Osman et al. propose that loss of CD10 expression is associated with an unfavorable patient outcome.
Gene_expression (expression) of CD10
13) Confidence 0.77 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.43 Pain Relevance 0
Albrecht et al. [19] have reported a shift from membrane bound to cytoplasmic localization for CD10 in high-grade prostate cancer cells with a loss of CD10 expression in areas of high proliferative activity as indicated by Ki67 immunohistochemistry (n = 24, with perhaps around 7 containing CD10+ cancer cells based on their frequency).
Gene_expression (expression) of CD10 associated with cancer and prostate cancer
14) Confidence 0.77 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 0.85 Pain Relevance 0
CD10 is strongly expressed by normal prostatic luminal epithelial cells and is a normal component of human prostasomes [3].
Gene_expression (expressed) of CD10 in epithelial cells
15) Confidence 0.77 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 0.78 Pain Relevance 0.14
Comparative array analysis among Gleason pattern 3, pattern 4 and pattern 5 tumors microdissected by laser-capture showed increased CD10 expression in the higher patterns [17]; a trend also reported by the study of Osman et al. [13].
Gene_expression (expression) of CD10 associated with cancer
16) Confidence 0.77 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.45 Pain Relevance 0
Normal tissue and well differentiated tumors of the colon and stomach express CD10 while poorly differentiated tumors from these sites show decreased expression [7].
Gene_expression (express) of CD10 in stomach associated with cancer
17) Confidence 0.77 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.26 Pain Relevance 0.10
A high percentage of prostate tumors show an early loss of CD10 expression [1,11].
Gene_expression (expression) of CD10 associated with prostate cancer
18) Confidence 0.77 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.47 Pain Relevance 0
This study also found a significant association between heterogeneous expression of CD10 and African American race.
Gene_expression (expression) of CD10
19) Confidence 0.77 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 0.96 Pain Relevance 0
Tawfic et al. [12] reported an absence of CD10 expression by Gleason grade 2 and 3 tumors however noted high expression of cytoplasmic and membranous CD10 in high Gleason tumors.
Gene_expression (expression) of CD10 associated with cancer
20) Confidence 0.77 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.53 Pain Relevance 0

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