INT4878

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.38
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MME) plasma membrane (MME) cell-cell signaling (MME)
Anatomy Link Frequency
lymph node 2
epithelial cells 2
melanocyte 2
MME (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 8 98.12 Very High Very High Very High
Enkephalin 6 97.40 Very High Very High Very High
Opioid 1 96.28 Very High Very High Very High
substance P 3 95.52 Very High Very High Very High
Neurotransmitter 2 81.24 Quite High
metalloproteinase 4 59.92 Quite High
dexamethasone 1 53.28 Quite High
cytokine 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 1 100.00 Very High Very High Very High
Cancer 305 99.84 Very High Very High Very High
Metastasis 54 99.48 Very High Very High Very High
Necrosis 2 98.92 Very High Very High Very High
Renal Cancer 78 98.60 Very High Very High Very High
Prostate Cancer 54 97.64 Very High Very High Very High
Amyloid Plaque 1 92.88 High High
Malignant Neoplastic Disease 14 89.68 High High
Disease 31 87.04 High High
Thyroid Neoplasm 2 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, in tumor necrosis factor (TNF)-treated immunocytes, we demonstrate the effects of increased NEP expression on altering the stimulatory activities of the neuropeptides met-enkephalin, melanocyte-stimulating hormone and substance P.
Regulation (effects) of Gene_expression (expression) of NEP in melanocyte associated with necrosis, cancer, neuropeptide, enkephalin and substance p
1) Confidence 0.53 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1281168 Disease Relevance 0.35 Pain Relevance 0.37
To study the regulation of NEP expression, we used human airway epithelial cells transformed in vitro with an origin-defective SV40 plasmid.
Regulation (regulation) of Gene_expression (expression) of NEP in epithelial cells
2) Confidence 0.49 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1847594 Disease Relevance 0 Pain Relevance 0.11
While primary tumors show a range of CD10 expression, lymph node metastases show nearly uniform high levels of expression [1].
Regulation (range) of Gene_expression (expression) of CD10 in lymph node associated with cancer and metastasis
3) Confidence 0.45 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.78 Pain Relevance 0
Correlation of CD10 expression with cancer grade and stage
Regulation (Correlation) of Gene_expression (expression) of CD10 associated with cancer
4) Confidence 0.45 Published 2007 Journal BMC Urol Section Body Doc Link PMC1829163 Disease Relevance 1.42 Pain Relevance 0
Changes were not significant for DPP IV (Figure 3A) nor NEP expression (Figure 3B) in CCRCC and RO tumors when compared with their corresponding normal tissues.
Neg (not) Regulation (significant) of Gene_expression (expression) of NEP associated with cancer
5) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.65 Pain Relevance 0
Moreover, the present manuscript shows that the modifications affecting DPP IV and NEP profiles along the different phenotypes of renal cancer are similar to those we observed in our previous studies on other membrane-bound peptidases, such as IRAP, APN and APA [12,13,28], and thus reinforces the idea that loss of several physiologically significant glycopeptidases may be a critical step in the etiogenesis of renal tumors.
Regulation (affecting) of Gene_expression (profiles) of NEP associated with renal cancer
6) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.91 Pain Relevance 0.03
Recently, it has been shown that two members of the neprilysin family cleave the Alzheimer's amyloid ?
Regulation (amyloid) of Gene_expression (family) of neprilysin associated with alzheimer's dementia
7) Confidence 0.04 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0.28 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox