INT48784

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 17
Disease Relevance 3.25
Pain Relevance 4.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIA1) endoplasmic reticulum (GRIA1) plasma membrane (GRIA1)
Anatomy Link Frequency
skin 2
neuronal 1
neurons 1
P-1 1
kidney 1
GRIA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 217 100.00 Very High Very High Very High
antagonist 11 100.00 Very High Very High Very High
nMDA receptor antagonist 1 100.00 Very High Very High Very High
Migraine 279 99.24 Very High Very High Very High
qutenza 7 98.88 Very High Very High Very High
Kinase C 5 98.80 Very High Very High Very High
gABA 4 97.88 Very High Very High Very High
Dorsal horn 2 95.96 Very High Very High Very High
tolerance 1 93.56 High High
Anterior cingulate cortex 82 92.92 High High
Disease Link Frequency Relevance Heat
Headache 273 99.24 Very High Very High Very High
Shock 21 93.36 High High
Neurodegenerative Disease 8 93.00 High High
Pain 26 92.80 High High
Hemiplegia 1 92.24 High High
Deafness 1 91.76 High High
Inflammatory Pain 9 91.20 High High
Depression 41 90.00 High High
Liver Disease 1 89.84 High High
Schizophrenia 6 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These variants modify binding sites for transcription factors altering the expression of GRIA1 and GRIA3 genes in different conditions.
Gene_expression (expression) of GRIA1
1) Confidence 0.78 Published 2010 Journal BMC Med. Genet. Section Body Doc Link 20579352 Disease Relevance 0.07 Pain Relevance 0
This same peptide was basally phosphorylated in recombinant GluR1 receptors transiently expressed in human embryonal kidney 293 cells.
Gene_expression (expressed) of GluR1 in kidney
2) Confidence 0.75 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7527845 Disease Relevance 0 Pain Relevance 0.24
Since GluR1-containing AMPA receptors (AMPARs) occur predominantly on inhibitory neurons in the dorsal horn, we suggest that the IFN-gamma-mediated increase in spontaneous activity and responsiveness to DRG axon stimulation, decrease in sensitivity to PTX and tendency for EPSC bursting result from a reduced expression of GluR1 on these neurons and not from a reduction in active GABA(A) receptors in the network.
Gene_expression (expression) of GluR1 in neurons associated with gaba and dorsal horn
3) Confidence 0.75 Published 2003 Journal Pain Section Abstract Doc Link 14659507 Disease Relevance 0 Pain Relevance 0.54
Primers used for GRIA1 SNP rs548294 were:
Gene_expression (used) of GRIA1
4) Confidence 0.66 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0 Pain Relevance 0
Further remarkable in our cohort is that GRIA1 and GRIA3 variants are associated to migraine in female but not in male subjects.
Gene_expression (variants) of GRIA1 associated with migraine
5) Confidence 0.66 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.28 Pain Relevance 0.31
Primers used for GRIA1 SNP rs2195450 were:
Gene_expression (rs2195450) of GRIA1
6) Confidence 0.66 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.05 Pain Relevance 0.05
Primers used for GRIA1 SNP rs548294 were:
Gene_expression (rs548294) of GRIA1
7) Confidence 0.66 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0 Pain Relevance 0
The other two subunits of AMPA receptor, GluA3 and GluA4 express at relative lower levels [21,22].
Gene_expression (express) of GluA
8) Confidence 0.65 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.31 Pain Relevance 0.80
These variants modify binding sites for transcription factors altering the expression of GRIA1 and GRIA3 genes in different conditions.


Gene_expression (expression) of GRIA1
9) Confidence 0.59 Published 2010 Journal BMC Med Genet Section Abstract Doc Link PMC2909201 Disease Relevance 0.37 Pain Relevance 0.34
Functional analysis of the associated GRIA1 variants
Gene_expression (analysis) of GRIA1
10) Confidence 0.58 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.09 Pain Relevance 0
These results indicate that AMPA receptors containing the GluR1 subunit may be regulated by extracellular signals working through the cAMP second messenger system as well as by synaptic activity, possibly acting through protein kinase C.
Gene_expression (containing) of AMPA associated with kinase c
11) Confidence 0.27 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7527845 Disease Relevance 0 Pain Relevance 0.19
Finally, the authors cite the progress achieved in the development of agents that interact with the glutamatergic system: NMDA channel blockers, competitive NMDA receptor antagonists, NR2B-selective antagonists, glutamate release inhibitors, glycineB antagonists, AMPA and kainate receptor antagonists, AMPA receptor-positive modulators and agents that act by modifying endogenous kynurenic acid metabolism.
Gene_expression (blockers) of AMPA associated with glutamate, nmda receptor antagonist and antagonist
12) Confidence 0.17 Published 1998 Journal Drug News Perspect. Section Abstract Doc Link 15616669 Disease Relevance 1.30 Pain Relevance 0.69
Capsaicin, at non-toxic amounts of 0.25 and 0.5 micromole/plate, expressed a dose-dependent inhibition of the mutagenicity of Glu-P-1 and PhIP when they are metabolically activated by rat, hamster and human liver S9 and of Trp-P-2 when activated by rat and hamster liver S9.
Gene_expression (expressed) of Glu-P-1 in P-1 associated with qutenza
13) Confidence 0.09 Published 2005 Journal Anticancer Res. Section Abstract Doc Link 15816527 Disease Relevance 0.07 Pain Relevance 0.51
The overall influence that the small changes in expression of Gria's, Grm's and Grik2 may have on synaptic activity and neuronal integrity would be difficult to predict.
Gene_expression (expression) of Gria in neuronal
14) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.34 Pain Relevance 0.36
CONCLUSIONS: These results, in human tissue, demonstrate that iGluR mRNA and protein expression are increased during persistent inflammation and that this increased activity may be involved in mediating clinical inflammatory pain in human skin.


Gene_expression (expression) of iGluR in skin
15) Confidence 0.01 Published 2008 Journal Br J Anaesth Section Body Doc Link 18238837 Disease Relevance 0.06 Pain Relevance 0
Real-time-polymerase chain reaction (PCR) and western blot analysis were used for quantitation of iGluR mRNA and protein in normal and inflamed human skin.
Gene_expression (quantitation) of iGluR in skin
16) Confidence 0.01 Published 2008 Journal Br J Anaesth Section Body Doc Link 18238837 Disease Relevance 0.09 Pain Relevance 0
Overexpression of ADAR2 in NPCs results in Q/R editing and expression of calcium-impermeable AMPA receptors, which prevents AMPA-mediated differentiation, suggesting a physiological role for the Q/R editing process and the importance of unedited AMPA receptor subunits in neurogenesis [46].
Gene_expression (expression) of AMPA associated with neurodegenerative disease
17) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.20 Pain Relevance 0.09

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