INT48787

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Context Info
Confidence 0.27
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.28
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIA1) endoplasmic reticulum (GRIA1) plasma membrane (GRIA1)
Anatomy Link Frequency
synapses 1
GRIA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 32 100.00 Very High Very High Very High
Glutamate 26 100.00 Very High Very High Very High
Pain 35 99.44 Very High Very High Very High
Kinase C 4 98.80 Very High Very High Very High
Migraine 47 98.32 Very High Very High Very High
long-term potentiation 43 97.96 Very High Very High Very High
Lasting pain 11 94.88 High High
central pain 1 87.60 High High
allodynia 5 86.92 High High
Action potential 3 86.48 High High
Disease Link Frequency Relevance Heat
Pain 50 99.44 Very High Very High Very High
Migraine With Aura 3 98.32 Very High Very High Very High
Injury 19 97.00 Very High Very High Very High
Autism 50 93.64 High High
Neuropathic Pain 11 86.92 High High
Headache 46 78.36 Quite High
Anxiety Disorder 8 74.64 Quite High
Stress 1 34.92 Quite Low
Nociception 11 18.32 Low Low
Depression 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate an involvement of GRIA1 and GRIA3 genes in the susceptibility to migraine with aura and encourage replication in other data sets.
Regulation (involvement) of GRIA1 associated with migraine
1) Confidence 0.27 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.32 Pain Relevance 0.36
These results indicate that AMPA receptors containing the GluR1 subunit may be regulated by extracellular signals working through the cAMP second messenger system as well as by synaptic activity, possibly acting through protein kinase C.
Regulation (regulated) of AMPA associated with kinase c
2) Confidence 0.25 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7527845 Disease Relevance 0 Pain Relevance 0.19
Such regulation by protein phosphorylation may be involved in short-term changes in synaptic efficacy thought to involve the functional modulation of AMPA receptors.
Regulation (modulation) of AMPA
3) Confidence 0.16 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7527845 Disease Relevance 0 Pain Relevance 0.13
AMPA glutamate receptors are responsive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) [13].
Regulation (responsive) of AMPA associated with glutamate receptor
4) Confidence 0.04 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC411038 Disease Relevance 0.25 Pain Relevance 0.28
Changes in glutamate AMPA receptors or so called postsynaptic mechanisms of LTP, may only represent early changes in central synapses.
Regulation (Changes) of AMPA in synapses associated with glutamate and long-term potentiation
5) Confidence 0.01 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0.72 Pain Relevance 0.92

General Comments

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