INT4880

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Context Info
Confidence 0.61
First Reported 1982
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 7.78
Pain Relevance 8.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MME) plasma membrane (MME) cell-cell signaling (MME)
Anatomy Link Frequency
Neutrophil 2
endometrium 1
granulocytes 1
endothelial cell 1
vessels 1
MME (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropathic pain 55 100.00 Very High Very High Very High
Enkephalin 33 100.00 Very High Very High Very High
Somatostatin 4 100.00 Very High Very High Very High
Pain 43 99.92 Very High Very High Very High
Neuropeptide 22 99.84 Very High Very High Very High
Gabapentin 10 99.84 Very High Very High Very High
Intractable pain 1 99.16 Very High Very High Very High
pregabalin 54 99.14 Very High Very High Very High
dexamethasone 3 98.96 Very High Very High Very High
Calcitonin gene-related peptide 1 98.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 59 100.00 Very High Very High Very High
Nociception 5 99.96 Very High Very High Very High
Intractable Pain 2 99.16 Very High Very High Very High
Benign Prostatic Hypertrophy 4 98.80 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 28 98.78 Very High Very High Very High
Deficiency Diseases 1 98.68 Very High Very High Very High
Pain 48 98.64 Very High Very High Very High
Renal Cancer 78 98.24 Very High Very High Very High
Depression 2 97.52 Very High Very High Very High
Prostate Cancer 89 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neutrophil cell surface CD10/NEP enzymatic activity is also shown to be regulated by the activation state of the cell during the time period in which the enzyme has its most pronounced effects.
Regulation (regulated) of CD10 in Neutrophil
1) Confidence 0.61 Published 1991 Journal Blood Section Abstract Doc Link 1717072 Disease Relevance 0.37 Pain Relevance 0.26
We have previously shown that neutral endopeptidase 24.11 (NEP) is an important enzyme in neuro- and autoimmunoregulation of both vertebrates and invertebrates, and that activation of human granulocytes by monokines and neuropeptides results in regulation of NEP.
Regulation (regulation) of NEP in granulocytes associated with neuropeptide
2) Confidence 0.53 Published 1994 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 7519178 Disease Relevance 0.32 Pain Relevance 0.66
Progesterone-regulated cyclic modulation of membrane metalloendopeptidase (enkephalinase) in human endometrium.
Regulation (modulation) of enkephalinase in endometrium
3) Confidence 0.50 Published 1991 Journal J. Biol. Chem. Section Title Doc Link 1744100 Disease Relevance 0.09 Pain Relevance 0.14
It is proposed the enkephalinase inhibitors may be effective in a number of human "endorphin deficiency diseases" such as depression, schizophrenia, convulsive disorders and arthritis.
Regulation (effective) of enkephalinase associated with depression, deficiency diseases, schizophrenia and arthritis
4) Confidence 0.45 Published 1982 Journal Acupunct Electrother Res Section Abstract Doc Link 6128872 Disease Relevance 0.58 Pain Relevance 0.82
Effects of an enkephalinase inhibitor on esophageal motility in man.
Regulation (Effects) of enkephalinase associated with enkephalin
5) Confidence 0.45 Published 1988 Journal Gastroenterol. Clin. Biol. Section Title Doc Link 3220232 Disease Relevance 0 Pain Relevance 0.49
The activity of the closely related enzyme neutral metalloenopeptidase (NEP) and the aminopeptidase N (APN) also present on the endothelial cell surface were not affected or slightly decreased by dexamethasone.
Neg (not) Regulation (affected) of NEP in endothelial cell associated with dexamethasone
6) Confidence 0.44 Published 1995 Journal Pharmazie Section Abstract Doc Link 7700968 Disease Relevance 0 Pain Relevance 0.39
However, such as in activity assays, a decreasing trend of mRNA levels was also observed for DPP IV in RO and for NEP in CCRCC and RO.
Regulation (trend) of NEP
7) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.60 Pain Relevance 0
The enkephalinase inhibitor, GB 52, does not affect nociceptive flexion reflexes nor pain sensation in humans.
Neg (nor) Regulation (affect) of enkephalinase associated with nociception, pain and enkephalin
8) Confidence 0.36 Published 1986 Journal Neuropharmacology Section Title Doc Link 3022176 Disease Relevance 1.03 Pain Relevance 0.87
Human nasal mucosa biopsy samples were studied by biochemical and histological methods to determine whether the concentration of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) as a marker of sensory nerves was dependent on the activity of neutral endopeptidase-like enzyme (NEP-LE).
Spec (whether) Regulation (dependent) of NEP-LE in nasal mucosa associated with calcitonin gene-related peptide
9) Confidence 0.30 Published 1995 Journal Eur Arch Otorhinolaryngol Section Abstract Doc Link 8719587 Disease Relevance 0.48 Pain Relevance 0.30
Neutrophil cell surface CD10/NEP enzymatic activity is also shown to be regulated by the activation state of the cell during the time period in which the enzyme has its most pronounced effects.
Regulation (regulated) of NEP in Neutrophil
10) Confidence 0.27 Published 1991 Journal Blood Section Abstract Doc Link 1717072 Disease Relevance 0.37 Pain Relevance 0.26
In addition to the modulating functions of NEP on neuropeptide-mediated activities on vessels and glands, it is possible that NEP in secretions plays a role in regulating mucosal responses to luminal neuropeptides or other as yet uncharacterized NEP substrates.
Regulation (modulating) of NEP in glands associated with neuropeptide
11) Confidence 0.24 Published 1993 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 8217197 Disease Relevance 0.08 Pain Relevance 0.10
These results indicate that NEP is a highly significant factor in controlling the response(s) of certain immunocytes in man and higher invertebrates to the influence of biologically active substances such as monokines and neuropeptides.
Regulation (controlling) of NEP associated with neuropeptide
12) Confidence 0.24 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1281168 Disease Relevance 0.30 Pain Relevance 0.35
Pregabalin showed efficacy benefits in patients with NeP inadequately controlled by gabapentin as 8 of the 9 pregabalin studies included patients, who had previously failed on gabapentin (Table 5).
Regulation (controlled) of NeP associated with pregabalin, neuropathic pain and gabapentin
13) Confidence 0.19 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3003252 Disease Relevance 0.78 Pain Relevance 2.10
Prior to the outbreak Vancouver had a low HIV prevalence rate and it was assumed that this was due to the effectiveness of the NEP.
Regulation (effectiveness) of NEP associated with acquired immune deficiency syndrome or hiv infection
14) Confidence 0.18 Published 2006 Journal Harm Reduct J Section Body Doc Link PMC1569828 Disease Relevance 0.62 Pain Relevance 0
The results show that an NEP-like enzyme on the surface of gastric muscle cells degrades and inactivates enkephalins, GRP-10 and somatostatin-14 and acts in a manner analogous to that of acetylcholinesterase in the neuromuscular junction of skeletal muscle.
Regulation (acts) of NEP-like enzyme in neuromuscular junction associated with somatostatin and enkephalin
15) Confidence 0.18 Published 1993 Journal Exp. Physiol. Section Abstract Doc Link 8448012 Disease Relevance 0 Pain Relevance 1.12
Moreover, the present manuscript shows that the modifications affecting DPP IV and NEP profiles along the different phenotypes of renal cancer are similar to those we observed in our previous studies on other membrane-bound peptidases, such as IRAP, APN and APA [12,13,28], and thus reinforces the idea that loss of several physiologically significant glycopeptidases may be a critical step in the etiogenesis of renal tumors.
Regulation (affecting) of NEP associated with renal cancer
16) Confidence 0.10 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.91 Pain Relevance 0.03
We speculate that the down-regulation of NEP may contribute to an increase in bioactive peptides required for prostate cancer growth and metastasis
Regulation (regulation) of NEP associated with prostate cancer and metastasis
17) Confidence 0.10 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 1.19 Pain Relevance 0.22
In addition to the modulating functions of NEP on neuropeptide-mediated activities on vessels and glands, it is possible that NEP in secretions plays a role in regulating mucosal responses to luminal neuropeptides or other as yet uncharacterized NEP substrates.
Regulation (modulating) of NEP in vessels associated with neuropeptide
18) Confidence 0.08 Published 1993 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 8217197 Disease Relevance 0.08 Pain Relevance 0.10

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