INT48803

Context Info Confidence 0.22 First Reported 1994 Last Reported 2008 Negated 0 Speculated 1 Reported most in Body Documents 9 Total Number 11 Disease Relevance 7.24 Pain Relevance 2.06

peptidase activity (CELA3B) extracellular region (CELA3B)

Anatomy Link Frequency alveolar macrophages 1 acinar cells 1 parathyroid 1 CELA3B (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 74 99.72 Chronic pancreatitis 29 98.56 Inflammation 42 93.84 Central nervous system 2 52.76 carpal tunnel syndrome 6 52.00 anesthesia 2 51.96 Multiple sclerosis 2 43.76 imagery 2 38.04 peripheral neuropathy 6 36.48 Somatostatin 1 30.68

Disease Link Frequency Relevance Heat Pulmonary Disease 106 98.72 Pancreatitis 39 98.56 Nicotine Addiction 173 98.48 Diabetes Mellitus 26 96.76 INFLAMMATION 45 93.84 Severe Acute Respiratory Syndrome 358 93.20 Adenocarcinoma 67 92.72 Islet Cell Adenoma 29 91.96 Demyelinating Disease 16 91.60 Neuropathic Pain 12 90.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Genes encoding digestive enzymes produced by acinar cells such as amylase (AMY2A), elastase (ELA3A, ELA3B), carboxypeptidase A (CPA2), pancreatic lipase (PNLIP), and trypsin (PRSS2) were enriched in this cluster (Figures 1, “Acinar” cluster).

Gene_expression (produced) of ELA3B in acinar cells

1) Confidence 0.22 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.09 Pain Relevance 0.07

Compared to controls, both D(3) vitamins, as well as fecal elastase 1, were extremely low (means in patients: fecal elastase 1, 140.7 +/- 75.7 micro g/g; 1,25(OH)(2)D(3), 29.9 +/- 9.5 pg/mL; 25(OH)D(3), 26.7 +/- 9.7 nmol/L; controls: fecal elastase 1, 694.9 +/- 138.6 micro g/g; 1,25(OH)(2)D(3), 67.5 +/- 4.3 pg/mL; 25(OH)D(3), 69.5 +/- 13.5 nmol/L).

Gene_expression (means) of fecal elastase 1

2) Confidence 0.11 Published 2003 Journal Metab. Clin. Exp. Section Abstract Doc Link 12759887 Disease Relevance 0.28 Pain Relevance 0.25

Dual energy x-ray absorptiometry (DEXA) was performed on patients and controls, and serum levels of parathyroid hormone (PTH), osteocalcin (OC), carboxy-terminal propeptide of type I procollagen (CICP), bone-specific alkaline phosphatase (BAP), 1,25(OH)(2) vitamin D(3) and 25(OH) vitamin D(3), as well as fecal elastase 1 were also determined.

Spec (determined) Gene_expression (determined) of fecal elastase 1 in parathyroid

3) Confidence 0.11 Published 2003 Journal Metab. Clin. Exp. Section Abstract Doc Link 12759887 Disease Relevance 0.49 Pain Relevance 0.42

Compared to controls, both D(3) vitamins, as well as fecal elastase 1, were extremely low (means in patients: fecal elastase 1, 140.7 +/- 75.7 micro g/g; 1,25(OH)(2)D(3), 29.9 +/- 9.5 pg/mL; 25(OH)D(3), 26.7 +/- 9.7 nmol/L; controls: fecal elastase 1, 694.9 +/- 138.6 micro g/g; 1,25(OH)(2)D(3), 67.5 +/- 4.3 pg/mL; 25(OH)D(3), 69.5 +/- 13.5 nmol/L).

Gene_expression (g/g) of fecal elastase 1

4) Confidence 0.11 Published 2003 Journal Metab. Clin. Exp. Section Abstract Doc Link 12759887 Disease Relevance 0.30 Pain Relevance 0.26

Compared to controls, both D(3) vitamins, as well as fecal elastase 1, were extremely low (means in patients: fecal elastase 1, 140.7 +/- 75.7 micro g/g; 1,25(OH)(2)D(3), 29.9 +/- 9.5 pg/mL; 25(OH)D(3), 26.7 +/- 9.7 nmol/L; controls: fecal elastase 1, 694.9 +/- 138.6 micro g/g; 1,25(OH)(2)D(3), 67.5 +/- 4.3 pg/mL; 25(OH)D(3), 69.5 +/- 13.5 nmol/L).

Gene_expression (means) of fecal elastase 1

5) Confidence 0.11 Published 2003 Journal Metab. Clin. Exp. Section Abstract Doc Link 12759887 Disease Relevance 0.28 Pain Relevance 0.25

An independent correlation between fecal elastase levels and, respectively, glycemic control and residual ?

Gene_expression (levels) of fecal elastase

6) Confidence 0.05 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518335 Disease Relevance 1.19 Pain Relevance 0.08

Baseline fecal elastase values were <10 ?

Gene_expression (values) of fecal elastase

7) Confidence 0.04 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518335 Disease Relevance 0.20 Pain Relevance 0

MMP-12 was first detected as an elastolytic proteinase in alveolar macrophages of cigarette smokers [16].

Gene_expression (detected) of proteinase in alveolar macrophages associated with nicotine addiction and metalloproteinase

8) Confidence 0.03 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.10 Pain Relevance 0.69

By gel electrophoresis and subsequent incubation with enzyme substrates, protease E, chymotrypsin C, and cathodic trypsin were first detected at 6-7 days of age, and the activities (semiquantitative densitometry) appeared lower in metyrapone-treated pigs than in pigs from other treatment groups.

Gene_expression (detected) of protease E

9) Confidence 0.01 Published 1994 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 7529304 Disease Relevance 0 Pain Relevance 0.05

Most of the coronaviruses express one major cysteine proteinase, called the main proteinase (Mpro) or the 3C-like proteinase (3CLpro), and two auxiliary, papain-like proteinases (PL1pro and PL2pro).

Gene_expression (express) of proteinase

10) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC548145 Disease Relevance 0.61 Pain Relevance 0

Most of the coronaviruses express one major cysteine proteinase, called the main proteinase (Mpro) or the 3C-like proteinase (3CLpro), and two auxiliary, papain-like proteinases (PL1pro and PL2pro).

Gene_expression (express) of proteinase

11) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC548145 Disease Relevance 0.71 Pain Relevance 0

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