INT48807

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Context Info
Confidence 0.13
First Reported 1994
Last Reported 2001
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) nucleus (Pax3) DNA binding (Pax3)
Pax3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 463 100.00 Very High Very High Very High
Spinal cord 4 93.12 High High
antinociception 1 83.76 Quite High
Potency 6 83.04 Quite High
imagery 2 50.00 Quite Low
agonist 8 47.20 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Reprotox - General 2 4 5.00 Very Low Very Low Very Low
Tics 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injection of SP(5-11) intrathecally did not affect the affinity (Kd) or concentration (Bmax) of [3H]SP binding.
Neg (not) Regulation (affect) of SP Binding (binding) of associated with substance p
1) Confidence 0.13 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7529387 Disease Relevance 0 Pain Relevance 1.22
Oregon Green 488 was found to be the most useful fluorophore for labeling SP without altering its biological activity, whereas Alexa 488 drastically altered the binding and activation of SP.


Regulation (altered) of SP Binding (binding) of associated with substance p
2) Confidence 0.03 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.45
Two-way analysis of variance followed by Student-Newman-Keuls test showed that there was a dose-dependent effect (p < 0.001) on the binding of unlabeled SP and the SP analogs to the rSPR.
Regulation (effect) of SP Binding (binding) of associated with substance p
3) Confidence 0.02 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.92

General Comments

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