INT48848

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Context Info
Confidence 0.34
First Reported 1994
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.95
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B, HLA-E)
Anatomy Link Frequency
T lymphocytes 1
HLA-B (Homo sapiens)
HLA-E (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 5 100.00 Very High Very High Very High
spinal inflammation 3 100.00 Very High Very High Very High
Inflammation 2 96.04 Very High Very High Very High
psoriasis 1 85.96 High High
cytokine 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 3 100.00 Very High Very High Very High
Low Back Pain 3 100.00 Very High Very High Very High
Disease 12 99.92 Very High Very High Very High
Infection 1 96.60 Very High Very High Very High
INFLAMMATION 1 96.04 Very High Very High Very High
Chlamydia Infection 3 94.08 High High
Disease Susceptibility 4 92.96 High High
Inflammatory Bowel Disease 1 87.32 High High
Psoriasis 1 85.96 High High
Arthritis 2 85.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The definition of human MHC class I haplotypes through association of HLA-A, HLA-Cw and HLA-B has been used to analyze ethnicity, population migrations and disease association.


HLA-B Binding (association) of MHC associated with disease
1) Confidence 0.34 Published 2007 Journal BMC Genet Section Abstract Doc Link PMC1853106 Disease Relevance 0.10 Pain Relevance 0
HLA-B27, like other MHC class I molecules, physiologically binds antigenic peptides in its binding groove and presents them to CD8+ T lymphocytes.
HLA-B27 Binding (binds) of MHC in T lymphocytes
2) Confidence 0.12 Published 1994 Journal Ann. Med. Section Abstract Doc Link 7530015 Disease Relevance 1.22 Pain Relevance 0.30
The association of HLA-B27 with ankylosing spondylitis and reactive arthritis is the strongest one known between an MHC class I Ag and a disease.
HLA-B27 Binding (association) of MHC associated with seronegative spondarthritis, spinal inflammation, disease and arthritis
3) Confidence 0.11 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11591805 Disease Relevance 0.63 Pain Relevance 0.15

General Comments

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