INT48853
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
On the other hand, the increase in total BDNF mRNA after 48 hours of treatment appeared to be mainly accounted for by the induction of BDNF IV by both drugs. | |||||||||||||||
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ProNGF levels were also found to be enhanced after CNS injury, together with upregulation of the p75 neurotrophin receptor and increased p75-mediated apoptosis [91]. | |||||||||||||||
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that RA effects may involve an upregulation of neurotrophin receptors, and | |||||||||||||||
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The same research group, using the two-way active-avoidance learning paradigm, showed that the increase in pontine-wave density during post-training REM sleep is positively correlated with the increased levels of phosphorylated cAMP response element-binding protein (CREB), brain-derived nerve growth factor (BDNF), and Arc protein in the dorsal hippocampus (Ulloor and Datta, 2005). | |||||||||||||||
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Whether both NGF and BDNF are upregulated in the degenerate IVD, and as such play a key role in innervation and the pathogenesis of low back pain, however, remains to be determined. | |||||||||||||||
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Recent animal and human studies have demonstrated that antidepressants can increase central as well as plasma BDNF levels. | |||||||||||||||
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Plasma BDNF was increased in the circulation in patients with unstable angina. | |||||||||||||||
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On the other hand, the increase in total BDNF mRNA after 48 hours of treatment appeared to be mainly accounted for by the induction of BDNF IV by both drugs. | |||||||||||||||
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In concert with this protection, there is an upregulation of neurotrophins [i.e., nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF)]. | |||||||||||||||
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In concert with this protection, there is an upregulation of neurotrophins [i.e., nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF)]. | |||||||||||||||
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Increased levels of BDNF are necessary for the survival of neurons. | |||||||||||||||
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Studies by Kemi and colleagues have demonstrated upregulation of NGF and BDNF in bronchial smooth muscle cells after treatment with IL-1 [26]. | |||||||||||||||
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Similarly, in the brain, the mature form consisted in 60% of total BDNF and the proBDNF in 40% of total BDNF (Fig. 9B). 30 min of acute stress had no effects on the total amount of BDNF in the brain but induced a highly significant increase in the proBDNF levels and a corresponding significant reduction in mature BDNF (p < 0.01 vs. control, Fig. 9B). | |||||||||||||||
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Western blot analysis showed that in brain, but not in liver, proBDNF content is significantly increased in the stressed samples. | |||||||||||||||
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It is well known that several intracellular pathways can mediate ERK phosphorylation in response to neurotrophins or other extracellular signals [47,48]. | |||||||||||||||
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Short-term treatment (6 hours) with reboxetine or desipramine reduced total BDNF, whereas long-term treatment (48 hours) significantly increased total BDNF mRNA levels. | |||||||||||||||
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Two way ANOVA showed significant effects of time (F2,144 = 37,42; p < .0001), drug (F2,144 = 23,39; p < .0001) and time/drug interaction (F4,144 = 26,94; p < .0001) for BDNF IV transcript: BDNF IV was significantly reduced after 6 hours and significantly increased after 48 h of RBX or DMI (Fig. 2B). | |||||||||||||||
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In addition, early social enrichment (offspring benefiting from the sharing of maternal care-giving by multiple females in a single nest) increases the brain's neurotrophin levels in young animals and shapes social competencies in adulthood[7]. | |||||||||||||||
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In rodent studies, mouse pups receiving high levels of maternal care show increased neurotrophin levels in the brain, which promotes sociability in adulthood[7]. | |||||||||||||||
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Therefore, tianeptines effectiveness as antidepressant treatment may result from its stabilization of neurotrophin levels in the amygdala. | |||||||||||||||
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