INT48860

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Context Info
Confidence 0.61
First Reported 1995
Last Reported 2010
Negated 6
Speculated 2
Reported most in Abstract
Documents 25
Total Number 27
Disease Relevance 20.68
Pain Relevance 8.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
alveolar macrophages 6
mast cells 6
hepatocyte 4
neuronal 4
monocytes 4
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 237 100.00 Very High Very High Very High
cytokine 54 100.00 Very High Very High Very High
antagonist 17 100.00 Very High Very High Very High
anesthesia 15 100.00 Very High Very High Very High
Paracetamol 12 100.00 Very High Very High Very High
Dopamine 10 100.00 Very High Very High Very High
noradrenaline 8 100.00 Very High Very High Very High
ketamine 4 99.80 Very High Very High Very High
Inflammatory response 30 99.70 Very High Very High Very High
Central nervous system 2 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 81 100.00 Very High Very High Very High
Necrosis 39 100.00 Very High Very High Very High
Stress 22 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 4 100.00 Very High Very High Very High
Enteropathy 1 99.64 Very High Very High Very High
INFLAMMATION 158 99.52 Very High Very High Very High
Sepsis 20 98.92 Very High Very High Very High
Hypersensitivity 3 98.44 Very High Very High Very High
Hemorrhage 10 98.24 Very High Very High Very High
Injury 54 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AIM: To investigate: (i) molecular events that regulate TNFalpha secretion in response to aspirin in vivo and in vitro; (ii) whether TNFalpha secretion inhibitors prevent aspirin-induced TNFalpha release and protect against gastric mucosal damage; and (iii) whether TNFalpha exerts a direct cytotoxic effect on gastric epithelial cells.
Regulation (regulate) of Localization (secretion) of TNFalpha in epithelial cells
1) Confidence 0.61 Published 1998 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9845404 Disease Relevance 0.10 Pain Relevance 0
Lipopolysaccharide-induced tumor necrosis factor-alpha release is controlled by the central nervous system.
Regulation (controlled) of Localization (release) of tumor necrosis factor-alpha in central nervous system associated with necrosis, cancer and central nervous system
2) Confidence 0.60 Published 2001 Journal Neuroimmunomodulation Section Title Doc Link 11752888 Disease Relevance 0.47 Pain Relevance 0.34
Compared to controls, the prostaglandin derivative latanoprost and the beta-blocker timolol in the concentration range 0.1-30 microM, had no significant effect on TNF-alpha release from rat mast cells measured 5h after activation.
Neg (no) Regulation (effect) of Localization (release) of TNF-alpha in mast cells associated with beta blocker
3) Confidence 0.57 Published 2006 Journal Exp. Eye Res. Section Abstract Doc Link 16965772 Disease Relevance 0.42 Pain Relevance 0.32
We conclude that release of TNF-alpha, [NO3/NO2], and leptin are neurally controlled since plasma levels of all three declined as a result of anesthesia.
Regulation (controlled) of Localization (release) of TNF-alpha in plasma associated with anesthesia
4) Confidence 0.57 Published 2001 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 11368420 Disease Relevance 0.42 Pain Relevance 0.35
AlOH alone did not affect TNF-alpha release, but decreased TNF-alpha production in the presence of LPS.
Neg (not) Regulation (affect) of Localization (release) of TNF-alpha
5) Confidence 0.56 Published 2006 Journal Toxicol In Vitro Section Abstract Doc Link 16782301 Disease Relevance 0.34 Pain Relevance 0.26
In contrast to this finding, TNF-alpha release from hepatocyte cultures was not affected after H2O2 treatment.
Neg (not) Regulation (affected) of Localization (release) of TNF-alpha in hepatocyte
6) Confidence 0.46 Published 1997 Journal Toxicology Section Abstract Doc Link 9230444 Disease Relevance 0.28 Pain Relevance 0.39
Influence of acetaminophen treatment and hydrogen peroxide treatment on the release of a CINC-related protein and TNF-alpha from rat hepatocyte cultures.
Regulation (Influence) of Localization (release) of TNF-alpha in hepatocyte associated with paracetamol
7) Confidence 0.46 Published 1997 Journal Toxicology Section Title Doc Link 9230444 Disease Relevance 0.11 Pain Relevance 0.28
It is known that application of tumor-necrosis-factor-alpha (TNF-alpha) sensitizes neuronal calcium channels for heat stimuli in rat models of neuropathic pain.
Regulation (sensitizes) of Localization (application) of TNF-alpha in neuronal associated with necrosis, cancer, calcium channel and neuropathic pain
8) Confidence 0.45 Published 2010 Journal Brain Res. Bull. Section Abstract Doc Link 19818386 Disease Relevance 0.73 Pain Relevance 0.53
It is known that application of tumor-necrosis-factor-alpha (TNF-alpha) sensitizes neuronal calcium channels for heat stimuli in rat models of neuropathic pain.
Regulation (sensitizes) of Localization (application) of tumor-necrosis-factor-alpha in neuronal associated with necrosis, cancer, calcium channel and neuropathic pain
9) Confidence 0.45 Published 2010 Journal Brain Res. Bull. Section Abstract Doc Link 19818386 Disease Relevance 0.73 Pain Relevance 0.53
Once a systemic inflammatory response is triggered, circulating monocytes and alveolar macrophages secrete cytokines including tumor necrosis factor alpha (TNF-?)
Regulation (circulating) of Localization (secrete) of TNF in alveolar macrophages associated with necrosis, inflammatory response, cancer and cytokine
10) Confidence 0.44 Published 2004 Journal Crit Care Section Body Doc Link PMC522843 Disease Relevance 2.58 Pain Relevance 0.63
targets the tumor vasculature, which is a common denominator in all these tumor types, the use of TNF-?
Regulation (targets) of Localization (use) of TNF in vasculature associated with cancer
11) Confidence 0.44 Published 2007 Journal Curr Treat Options Oncol Section Body Doc Link PMC2781100 Disease Relevance 0.68 Pain Relevance 0
Comparisons of the effects of anesthesia and stress on release of tumor necrosis factor-alpha, leptin, and nitric oxide in adult male rats.
Regulation (effects) of Localization (release) of tumor necrosis factor-alpha associated with stress, necrosis, anesthesia and cancer
12) Confidence 0.44 Published 2001 Journal Exp. Biol. Med. (Maywood) Section Title Doc Link 11368420 Disease Relevance 0.58 Pain Relevance 0.37
To test our hypothesis that such a rapid increase of TNF-alpha would be either neurally or hormonally controlled, the effect on TNF-alpha release of anesthesia (ketamine/acepromazine/xylazine) and catecholaminergic agonists and antagonists, either alone or in the presence of LPS, was determined.
Regulation (effect) of Localization (release) of TNF-alpha associated with anesthesia, ketamine, antagonist and agonist
13) Confidence 0.44 Published 2001 Journal Neuroimmunomodulation Section Abstract Doc Link 11752888 Disease Relevance 0.42 Pain Relevance 0.37
Phosphodiesterase inhibitors prevent NSAID enteropathy independently of effects on TNF-alpha release.
Regulation (effects) of Localization (release) of TNF-alpha associated with enteropathy and cinod
14) Confidence 0.43 Published 1999 Journal Am. J. Physiol. Section Title Doc Link 10516151 Disease Relevance 0.60 Pain Relevance 0.69
Role of tumor necrosis factor alpha release and leukocyte margination in indomethacin-induced gastric injury in rats.
Regulation (Role) of Localization (release) of tumor necrosis factor alpha in leukocyte associated with necrosis, cancer and injury
15) Confidence 0.43 Published 1995 Journal Gastroenterology Section Title Doc Link 7530670 Disease Relevance 0.74 Pain Relevance 0.13
Effect of GLC756, a novel mixed dopamine D1 receptor antagonist and dopamine D2 receptor agonist, on TNF-alpha release in vitro from activated rat mast cells.
Regulation (Effect) of Localization (release) of TNF-alpha in mast cells associated with dopamine, antagonist and agonist
16) Confidence 0.42 Published 2006 Journal Exp. Eye Res. Section Title Doc Link 16965772 Disease Relevance 0.46 Pain Relevance 0.28
This study examined the influence of three antiglaucoma drugs differing in their chemical structure and pharmacological profile (i.e. latanoprost, timolol, GLC756) on TNF-alpha release from activated rat mast cells.
Spec (examined) Regulation (influence) of Localization (release) of TNF-alpha in mast cells
17) Confidence 0.42 Published 2006 Journal Exp. Eye Res. Section Abstract Doc Link 16965772 Disease Relevance 0.48 Pain Relevance 0.23
APAP by itself did not alter release of TNF-alpha, PGE(2), IL-10, Gro/KC or IFN-gamma; however, in the presence of LPS, APAP enhanced LPS-induced TNF-alpha and Gro/KC release.
Neg (not) Regulation (alter) of Localization (release) of TNF-alpha
18) Confidence 0.41 Published 2006 Journal Toxicol In Vitro Section Abstract Doc Link 16782301 Disease Relevance 0.39 Pain Relevance 0.27
MCT by itself did not affect release of TNF-alpha but increased the response to LPS.
Neg (not) Regulation (affect) of Localization (release) of TNF-alpha
19) Confidence 0.41 Published 2006 Journal Toxicol In Vitro Section Abstract Doc Link 16782301 Disease Relevance 0.26 Pain Relevance 0.22
At 7 days, significant (P < 0.05) differences were found in Interleukin-1beta and tumor necrosis factor-alpha release for Nano-PCL when compared to Nano-D400G, and for PCL in comparison with D400G.
Regulation (found) of Localization (release) of tumor necrosis factor-alpha associated with necrosis and cancer
20) Confidence 0.33 Published 2006 Journal J Biomater Sci Polym Ed Section Abstract Doc Link 17260511 Disease Relevance 0.29 Pain Relevance 0.17

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