INT4887

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Context Info
Confidence 0.77
First Reported 1987
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 70
Total Number 73
Disease Relevance 11.66
Pain Relevance 40.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Tac4)
Anatomy Link Frequency
striatum 22
neurons 9
ventromedial hypothalamic nucleus 2
paw 2
dorsal root ganglia 2
Tac4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 383 100.00 Very High Very High Very High
Neuropeptide 119 100.00 Very High Very High Very High
Enkephalin 101 100.00 Very High Very High Very High
Somatostatin 56 100.00 Very High Very High Very High
Calcitonin gene-related peptide 54 100.00 Very High Very High Very High
Glutamate 24 100.00 Very High Very High Very High
projection neuron 6 100.00 Very High Very High Very High
dopamine receptor 5 100.00 Very High Very High Very High
Cholecystokinin 42 99.92 Very High Very High Very High
Deafferentation 20 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 4 99.70 Very High Very High Very High
Bronchitis 3 99.24 Very High Very High Very High
Dyskinesias 7 98.76 Very High Very High Very High
Nociception 38 98.52 Very High Very High Very High
Urological Neuroanatomy 36 98.44 Very High Very High Very High
Ganglion Cysts 99 98.16 Very High Very High Very High
Asthma 1 96.96 Very High Very High Very High
INFLAMMATION 34 96.80 Very High Very High Very High
Pain 78 95.92 Very High Very High Very High
Syndrome 3 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we report that transection of the infraorbital nerve, a major branch of the maxillary nerve, causes exaggerated face grooming to normally innocuous mechanical stimuli in the skin territory of the uninjured mandibular nerve, and increases the expression of preprotachykinin mRNA in the primary afferent neurons in the mandibular zone in the trigeminal ganglia.
Gene_expression (expression) of preprotachykinin mRNA in afferent neurons
1) Confidence 0.77 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12809988 Disease Relevance 0.18 Pain Relevance 0.33
Normalization of striatal proenkephalin and preprotachykinin mRNA expression by fetal substantia nigra grafts.
Gene_expression (expression) of preprotachykinin mRNA in substantia nigra associated with substantia nigra and enkephalin
2) Confidence 0.77 Published 1993 Journal Exp. Neurol. Section Title Doc Link 8432341 Disease Relevance 0 Pain Relevance 0.24
The expression of striatal proenkephalin and preprotachykinin mRNA was studied in Wistar rats following unilateral injections of 6-hydroxydopamine into the nigrostriatal pathway and after grafting dopaminergic fetal cell suspensions into the dopamine-depleted striatum.
Gene_expression (expression) of preprotachykinin mRNA in striatum associated with dopamine
3) Confidence 0.77 Published 1993 Journal Exp. Neurol. Section Abstract Doc Link 8432341 Disease Relevance 0 Pain Relevance 0.12
Striatal dopaminergic deafferentation resulted in an amphetamine-induced rotational asymmetry, an increase in ipsilateral striatal proenkephalin mRNA, and a decrease in preprotachykinin mRNA expression.
Gene_expression (expression) of preprotachykinin mRNA associated with deafferentation
4) Confidence 0.77 Published 1993 Journal Exp. Neurol. Section Abstract Doc Link 8432341 Disease Relevance 0 Pain Relevance 0.13
This study has demonstrated long-term graft-induced functional recovery coincident with normalization of striatal proenkephalin and preprotachykinin mRNA expression.
Gene_expression (expression) of preprotachykinin mRNA
5) Confidence 0.77 Published 1993 Journal Exp. Neurol. Section Abstract Doc Link 8432341 Disease Relevance 0 Pain Relevance 0.12
Furthermore, co-stimulation of dopamine(D1) and serotonin(2) receptors produced a nearly four-fold induction of preprotachykinin message levels in the dorsomedial striatum that was significantly greater than either agonist alone.
Gene_expression (produced) of preprotachykinin in striatum associated with dopamine, agonist and serotonin
6) Confidence 0.73 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516832 Disease Relevance 0 Pain Relevance 0.86
This study examined the effects of thalamo-striatal deafferentation on preprotachykinin and preproenkephalin mRNA expression in the rat neostriatum, using quantitative in situ hybridization histochemistry.
Gene_expression (expression) of preprotachykinin associated with deafferentation
7) Confidence 0.72 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9675424 Disease Relevance 0 Pain Relevance 0.09
However, at 5 days post-lesion, the regional analysis revealed a slight decrease (-17%) in preprotachykinin mRNA expression, confined to the dorsolateral part of the ipsilateral striatum.
Gene_expression (expression) of preprotachykinin mRNA in striatum
8) Confidence 0.72 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9675424 Disease Relevance 0 Pain Relevance 0.15
Thalamo-striatal deafferentation affects preproenkephalin but not preprotachykinin gene expression in the rat striatum.
Gene_expression (expression) of preprotachykinin in striatum associated with enkephalin and deafferentation
9) Confidence 0.72 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9675424 Disease Relevance 0 Pain Relevance 0.20
In parallel, no significant change in preprotachykinin mRNA expression was found at either 5 or 12 days after thalamic lesion, when considering the striatum as a whole.
Gene_expression (expression) of preprotachykinin mRNA in striatum
10) Confidence 0.72 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9675424 Disease Relevance 0 Pain Relevance 0.13
In situ hybridization histochemistry was used to investigate the expression of striatal preproenkephalin and preprotachykinin messenger ribonucleic acid (mRNA) in rats with 6-hydroxydopamine lesions of the nigrostriatal pathway followed 4 weeks later by implantation of foetal dopamine cells into the denervated striatum.
Spec (investigate) Gene_expression (expression) of preprotachykinin in striatum associated with dopamine
11) Confidence 0.67 Published 1996 Journal Mov. Disord. Section Abstract Doc Link 8771066 Disease Relevance 0 Pain Relevance 0.17
Dopamine depletion appears to promote a synergistic interaction between dopamine(D1) and serotonin(2) receptors that leads to enhanced expression of striatal preprotachykinin mRNA levels.
Gene_expression (expression) of preprotachykinin associated with dopamine and serotonin
12) Confidence 0.63 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516832 Disease Relevance 0 Pain Relevance 0.76
Application of both agonists also elevated preprotachykinin mRNA expression within the dorsolateral striatum, but to a lesser extent.
Gene_expression (expression) of preprotachykinin in striatum associated with agonist
13) Confidence 0.63 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516832 Disease Relevance 0 Pain Relevance 0.89
Preprotachykinin mRNA levels in the intact striatum were unaltered 4 h following an i.p. injection of either SKF-38393 (1 mg/kg, dopamine(D1) partial agonist) or (+/-)-1-(4-Iodo-2,5-dimethoxyphenyl)-2-aminopropane (DOI 1 mg/kg, serotonin(2) agonist).
Gene_expression (levels) of Preprotachykinin in striatum associated with dopamine, agonist and serotonin
14) Confidence 0.63 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516832 Disease Relevance 0 Pain Relevance 0.83
We have previously demonstrated that the combined administration of dopamine(D1) and serotonin(2) receptor agonists to dopamine-depleted adult rats induced preprotachykinin mRNA expression within the periventricular rostral striatum to levels which were significantly different than what could be elicited by either agonist alone.
Gene_expression (expression) of preprotachykinin in striatum associated with dopamine, agonist and serotonin
15) Confidence 0.63 Published 2001 Journal Neuroscience Section Abstract Doc Link 11516832 Disease Relevance 0 Pain Relevance 0.66
These results show that thalamic lesion preferentially affects preproenkephalin vs. preprotachykinin gene expression in the striatum, suggesting, at the first site, a predominant influence of thalamo-striatal inputs on the enkephalin-containing striato-pallidal pathway.
Gene_expression (expression) of preprotachykinin in striatum associated with enkephalin
16) Confidence 0.63 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9675424 Disease Relevance 0 Pain Relevance 0.16
However, following chronic treatment with apomorphine, preprotachykinin messenger RNA expression approached control levels in a wider portion of the grafted striata (up to 1 mm from the border of the grafts).
Gene_expression (expression) of preprotachykinin
17) Confidence 0.59 Published 1993 Journal Neuroscience Section Abstract Doc Link 8115038 Disease Relevance 0.06 Pain Relevance 0.12
Neuropeptide messenger RNA expression in the 6-hydroxydopamine-lesioned rat striatum reinnervated by fetal dopaminergic transplants: differential effects of the grafts on preproenkephalin, preprotachykinin and prodynorphin messenger RNA levels.
Gene_expression (levels) of preprotachykinin in striatum associated with neuropeptide
18) Confidence 0.58 Published 1993 Journal Neuroscience Section Title Doc Link 8115038 Disease Relevance 0.08 Pain Relevance 0.46
Partial reversal of increased preproenkephalin messenger ribonucleic acid (mRNA) and decreased preprotachykinin mRNA by foetal dopamine cells in unilateral 6-hydroxydopamine-lesioned rat striatum parallels functional recovery.
Gene_expression (reversal) of preprotachykinin in striatum associated with dopamine and enkephalin
19) Confidence 0.58 Published 1996 Journal Mov. Disord. Section Title Doc Link 8771066 Disease Relevance 0 Pain Relevance 0.27
Also, we monitored the effects of the compound on preproenkephalin (PPE) and preprotachykinin (PPT) gene expression in rat striatum.
Gene_expression (expression) of preprotachykinin in striatum
20) Confidence 0.57 Published 2002 Journal Brain Res. Section Abstract Doc Link 12384245 Disease Relevance 0.08 Pain Relevance 0.16

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