INT48877

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 5.26
Pain Relevance 8.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tacr1) plasma membrane (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
T cells 3
plasma 1
spinal cord 1
spinal cord dorsal horn 1
small intestine 1
Tacr1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 176 100.00 Very High Very High Very High
antagonist 47 100.00 Very High Very High Very High
agonist 14 100.00 Very High Very High Very High
pruritus 71 99.68 Very High Very High Very High
depression 8 99.56 Very High Very High Very High
Inflammation 24 99.54 Very High Very High Very High
Pain 40 99.50 Very High Very High Very High
Spinal cord 14 99.44 Very High Very High Very High
tetrodotoxin 3 99.08 Very High Very High Very High
Neuropeptide 11 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pruritus 82 99.68 Very High Very High Very High
Depression 8 99.56 Very High Very High Very High
INFLAMMATION 20 99.54 Very High Very High Very High
Pain 37 99.50 Very High Very High Very High
Neurogenic Inflammation 4 99.32 Very High Very High Very High
Anxiety Disorder 4 98.96 Very High Very High Very High
Colitis 15 94.20 High High
Nociception 13 93.24 High High
Skin Diseases 3 90.28 High High
Sarcoma 2 89.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since NK1 receptor agonists differ in their receptor interaction, we set out to compare a range of NK1 receptor agonists including SPOME, septide and GR-73 632 in their effects on propulsive peristalsis and circular muscle activity in the guinea-pig isolated small intestine.
NK1 receptor Binding (interaction) of in small intestine associated with agonist
1) Confidence 0.43 Published 2000 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 10877607 Disease Relevance 0.07 Pain Relevance 0.26
Substance P (SP) is a proinflammatory molecule that interacts with a neurokinin 1 receptor (NK-1R), which is on T cells and helps control IFN-gamma production.
neurokinin 1 receptor Binding (interacts) of in T cells associated with substance p
2) Confidence 0.42 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14500676 Disease Relevance 0.48 Pain Relevance 0.50
After 5 min, NK1 receptor IR was partially internalised, at 20 min NK1 receptor IR was throughout the cytoplasm and in perinuclear aggregates and at 30 min it was again at the cell surface.
NK1 receptor Binding (internalised) of
3) Confidence 0.34 Published 1996 Journal Histochem. Cell Biol. Section Abstract Doc Link 8985744 Disease Relevance 0 Pain Relevance 0.51
The final targets for the signaling pathway initiated by SP binding to NK1R to result in SP-driven feed-forward inhibition in the spinal cord dorsal horn are still a mystery. (3) Although SP and NKA are synthesized together, they affect spinal nociception in different ways [24, 25].
NK1R Binding (binding) of in spinal cord dorsal horn associated with nociception, dorsal horn, spinal cord and substance p
4) Confidence 0.33 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.09 Pain Relevance 0.71
Here we identify epitopes on the NK1 receptor responsible for the specific binding of CP 96345 by systematic exchange of corresponding segments between the NK1 receptor and the homologous NK3 (neurokinin B) receptor, which does not bind the non-peptide ligand.
NK1 receptor Binding (binding) of associated with substance p
5) Confidence 0.33 Published 1993 Journal Nature Section Abstract Doc Link 7681152 Disease Relevance 0.20 Pain Relevance 0.56
Substance P (SP) is a proinflammatory molecule that interacts with a neurokinin 1 receptor (NK-1R), which is on T cells and helps control IFN-gamma production.
NK-1R Binding (interacts) of in T cells associated with substance p
6) Confidence 0.33 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14500676 Disease Relevance 0.48 Pain Relevance 0.50
Thus, intestinal inflammation in IL-10(-/-) mice is associated with the appearance of NK-1R in mucosal T cells, and an interplay between IL-12 and IL-10 regulates T cell NK-1R transcription.
NK-1R Spec (appearance) Binding (associated) of in T cells associated with inflammation
7) Confidence 0.31 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14500676 Disease Relevance 0.81 Pain Relevance 0.83
Accumulating evidence indicates that the neuropeptide substance P (SP) is predominantly involved in neurogenic inflammation and pain perception via its high-affinity neurokinin 1 receptor (NK-1R).
neurokinin 1 receptor Binding (affinity) of associated with pain, inflammation, neuropeptide, neurogenic inflammation and substance p
8) Confidence 0.27 Published 2006 Journal J. Mol. Med. Section Abstract Doc Link 16389545 Disease Relevance 0.47 Pain Relevance 0.42
These findings suggest that [D-Trp7]sendide interacts selectively with the NK1 receptor in the mouse spinal cord as assayed by the receptor binding and SP-induced behavioural tests.
NK1 receptor Binding (interacts) of in spinal cord associated with substance p and spinal cord
9) Confidence 0.26 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7531295 Disease Relevance 0 Pain Relevance 0.70
Different binding epitopes on the NK1 receptor for substance P and non-peptide antagonist.
NK1 receptor Binding (binding) of associated with antagonist and substance p
10) Confidence 0.25 Published 1993 Journal Nature Section Title Doc Link 7681152 Disease Relevance 0.17 Pain Relevance 0.55
Non-conserved residues, in two epitopes around the top of transmembrane segment V and in one epitope at the top of transmembrane segment VI, are essential for the specific action of CP 96345 on the NK1 receptor, but are surprisingly not important for the binding of the natural peptide ligand, substance P.
NK1 receptor Binding (binding) of associated with substance p
11) Confidence 0.25 Published 1993 Journal Nature Section Abstract Doc Link 7681152 Disease Relevance 0.16 Pain Relevance 0.59
As a positive control we determined that substance-P-saporin bound to its receptor.
substance-P-saporin Binding (bound) of
12) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.27 Pain Relevance 0.04
Fluorescent activated cell sorting (FACS) analysis was used and determined that, indeed, HCRT2-SAP bound to the HCRT receptor but not the substance-P receptor.
substance-P receptor Binding (bound) of
13) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.29 Pain Relevance 0.07
As it binds to the neurokinin receptor 1 (NKR1), we evaluated if the application of a NKR1 antagonist would significantly decrease chronic pruritus.


neurokinin receptor 1 Binding (binds) of associated with antagonist and pruritus
14) Confidence 0.07 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2881044 Disease Relevance 0.68 Pain Relevance 0.49
The NK1 receptor localizes to the plasma membrane microdomains, and its activation is dependent on lipid raft integrity.
NK1 receptor Binding (localizes) of in plasma
15) Confidence 0.07 Published 2005 Journal J. Biol. Chem. Section Title Doc Link 15590676 Disease Relevance 0.12 Pain Relevance 0.13
The highly selective NK1 receptor antagonists CP 99994, GR 82334 and RP 67580 were ineffective in both binding and functional studies.
NK1 receptor Binding (binding) of associated with antagonist
16) Confidence 0.02 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10494889 Disease Relevance 0 Pain Relevance 0.32
Do substance P and the NK1 receptor have a role in depression and anxiety?
NK1 receptor Binding (have) of associated with depression, anxiety disorder and substance p
17) Confidence 0.02 Published 2005 Journal Curr. Pharm. Des. Section Title Doc Link 15892660 Disease Relevance 0.97 Pain Relevance 0.88

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox