INT4888

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Context Info
Confidence 0.54
First Reported 1992
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 2.78
Pain Relevance 5.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (Ppt1) Golgi apparatus (Ppt1) cytosol (Ppt1)
extracellular space (Ppt1) protein modification process (Ppt1) extracellular region (Ppt1)
Anatomy Link Frequency
DRG 8
sensory neurons 4
nucleus 2
parabrachial nucleus 2
Ppt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 40 100.00 Very High Very High Very High
parabrachial 2 100.00 Very High Very High Very High
Calcitonin gene-related peptide 15 99.80 Very High Very High Very High
qutenza 11 99.72 Very High Very High Very High
Sciatic nerve 3 99.16 Very High Very High Very High
Nerve growth factor 7 98.04 Very High Very High Very High
antagonist 8 96.92 Very High Very High Very High
agonist 4 96.72 Very High Very High Very High
Locus ceruleus 2 96.56 Very High Very High Very High
Neuropeptide 10 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 96.24 Very High Very High Very High
Arthritis 11 95.24 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 2 86.80 High High
Sleep Disorders 5 86.48 High High
Depression 4 85.44 High High
Neurogenic Inflammation 2 84.08 Quite High
Pain 8 82.96 Quite High
Experimental Arthritis 2 79.96 Quite High
Nociception 6 78.44 Quite High
Stress 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PPT expression in the lateral parabrachial nucleus also showed preshockxnoise interaction (up after noise in controls, higher basal and down after noise in preshocked), and was increased after noise in the periaquaeductal grey.
Positive_regulation (increased) of Gene_expression (expression) of PPT in parabrachial nucleus associated with parabrachial
1) Confidence 0.54 Published 2008 Journal Brain Res. Section Abstract Doc Link 18440496 Disease Relevance 0.40 Pain Relevance 0.62
The precise role of 5-HT(2) receptor on PPT-A mRNA biosynthesis after a neonatal lesion should be clarified by further experiments using 5-HT(2) agonists.
Positive_regulation (role) of Gene_expression (biosynthesis) of PPT associated with agonist
2) Confidence 0.49 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11754083 Disease Relevance 0 Pain Relevance 0.39
These data suggest that increased synthesis of PPT and CGRP peptides in DRG may play a role in the pathogenesis both of adjuvant-mediated acute inflammation and chronic arthritis.
Positive_regulation (increased) of Gene_expression (synthesis) of PPT in DRG associated with inflammation, arthritis and calcitonin gene-related peptide
3) Confidence 0.35 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1281253 Disease Relevance 0.57 Pain Relevance 0.67
These findings show that phosphorylation of specific protein tyrosine residue(s) following IL-1 receptor activation might play a key role in IL-1beta signalling to modulate PPT gene expression and SP secretion in sensory neurons.
Positive_regulation (following) of Gene_expression (expression) of PPT gene in sensory neurons associated with substance p
4) Confidence 0.34 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622206 Disease Relevance 0 Pain Relevance 0.47
These findings show that phosphorylation of specific protein tyrosine residue(s) following IL-1 receptor activation might play a key role in IL-1beta signalling to modulate PPT gene expression and SP secretion in sensory neurons.
Positive_regulation (modulate) of Gene_expression (expression) of PPT gene in sensory neurons associated with substance p
5) Confidence 0.34 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622206 Disease Relevance 0 Pain Relevance 0.43
Formalin (2 or 6 hr) or CFA (4 d) injection produced approximately a twofold increase in SP-encoding PPT mRNA expression in the ipsilateral lumbar DRG.
Positive_regulation (increase) of Gene_expression (expression) of PPT mRNA in DRG associated with substance p
6) Confidence 0.33 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8301359 Disease Relevance 0.27 Pain Relevance 0.69
Using in situ hybridization we found marked increases in expression of beta-preprotachykinin (PPT; 81 +/- 24% rise) and alpha-CGRP (44 +/- 6% rise) mRNAs in innervating (ipsilateral L5) DRG neurones only.
Positive_regulation (increases) of Gene_expression (expression) of PPT in DRG associated with calcitonin gene-related peptide
7) Confidence 0.30 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1281253 Disease Relevance 0.42 Pain Relevance 0.69
In contrast, gamma-PPT mRNA and trkA mRNA expression in DRG were significantly increased after capsaicin treatment.
Positive_regulation (increased) of Gene_expression (expression) of PPT in DRG associated with qutenza
8) Confidence 0.24 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9259450 Disease Relevance 0.79 Pain Relevance 1.57
Stimulation of the posterior hypothalamus (PH) or pedunculo pontine tegmental nucleus (PPT) was conducted with biphasic square-wave pulses, 0.1 ms in duration at a frequency of 100 Hz for a duration of 5 to 15 seconds (Model 2100, A-M Systems Inc.
Positive_regulation (Stimulation) of Gene_expression (nucleus) of PPT in nucleus
9) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289875 Disease Relevance 0.32 Pain Relevance 0.31
This study was performed to test whether biosynthesis of tachykinins plays a pivotal role in lipopolysaccharide (LPS)-induced airway alteration by analyzing preprotachykinin-I (PPT-I, a precursor of tachykinins) gene expression.
Spec (analyzing) Positive_regulation (analyzing) of Gene_expression (expression) of PPT-I
10) Confidence 0.17 Published 2003 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 12738685 Disease Relevance 0 Pain Relevance 0

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