INT48880

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 8.60
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TWIST1) DNA binding (TWIST1) transcription factor binding (TWIST1)
Anatomy Link Frequency
T24 3
SCs 3
myoblast 1
Notch 1
Muscle 1
TWIST1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal-cord stimulation 18 100.00 Very High Very High Very High
Spinal cord 16 100.00 Very High Very High Very High
gABA 5 98.24 Very High Very High Very High
Serotonin 4 93.68 High High
Dorsal horn 6 92.32 High High
substance P 4 87.32 High High
fibrosis 10 82.52 Quite High
medulla 1 79.20 Quite High
cytokine 54 77.56 Quite High
tolerance 6 75.04 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 7 99.84 Very High Very High Very High
Cervical Cancer 2 99.72 Very High Very High Very High
Prostate Cancer 212 99.48 Very High Very High Very High
Reprotox - General 1 9 98.92 Very High Very High Very High
Cancer 406 98.74 Very High Very High Very High
Urological Neuroanatomy 6 97.76 Very High Very High Very High
Injury 82 93.24 High High
Metastasis 82 90.64 High High
Liver Disease 30 84.24 Quite High
Stomach Cancer 4 83.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Twist, a novel oncogene, is upregulated in pancreatic cancer: clinical implication of Twist expression in pancreatic juice.
Positive_regulation (upregulated) of Twist associated with pancreatic cancer
1) Confidence 0.59 Published 2007 Journal Int. J. Cancer Section Title Doc Link 17236203 Disease Relevance 1.58 Pain Relevance 0
In PC346DCC, activation of VAV3 and TWIST1 oncogenes and down-regulation of DKK3 tumor suppressor constitutes a possible mechanism for bypassing the AR pathway.
Positive_regulation (activation) of TWIST1 associated with cancer
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.01 Pain Relevance 0.04
Src kinases are also activators of VAV3 and TWIST1, either directly by phosphorylating and releasing inhibitory tyrosine Y173 of VAV3, or indirectly by activating STAT3, a transcription activator for TWIST1 [58], [59].
Positive_regulation (activators) of TWIST1
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.27 Pain Relevance 0
However, since TWIST1 is strongly up-regulated in PCa samples it may still be useful as a cancer marker or therapeutical target.
Positive_regulation (up) of TWIST1 associated with cancer and prostate cancer
4) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.48 Pain Relevance 0
However, since TWIST1 is strongly up-regulated in PCa samples it may still be useful as a cancer marker or therapeutical target.
Positive_regulation (-) of TWIST1 associated with cancer and prostate cancer
5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.48 Pain Relevance 0
The expression of Twist, for example, has been found to be elevated in various types of cancer, including breast, prostate, and cervical cancer, with higher levels of Twist protein being detected in prostate cancer tissues of high Gleason score [38, 39].
Positive_regulation (levels) of Twist associated with cervical cancer, cancer and reprotox - general 1
6) Confidence 0.22 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.96 Pain Relevance 0
The effects of SCS on CBF are most likely mediated through the sympathetic nervous system, since cerebral vasculature is highly sympathetically innervated and the vascular diameter is related to sympathetic tone [18].
Positive_regulation (mediated) of SCS in sympathetic associated with spinal-cord stimulation
7) Confidence 0.14 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2901492 Disease Relevance 0.23 Pain Relevance 0.64
Additionally, the timing of increased IL-6 levels in the SCs in the current study is in agreement with previous in vitro findings from animal studies [51] that demonstrate a role for IL-6 in myoblast proliferation.
Positive_regulation (increased) of SCs in myoblast
8) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.06 Pain Relevance 0
We observed p-STAT3 within the SCs at T4, with the downstream genes cyclin D1 and SOCS3 increasing from T4-T24, suggesting that the IL-6/STAT3 signaling pathway was active within SCs early, during early proliferation, prior to the expansion of the SC population.
Positive_regulation (active) of SCs in T24
9) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.14 Pain Relevance 0.03
Furthermore, the number of SCs was not significantly increased until T24, which suggests a potential role for IL-6 in newly proliferating SCs.
Neg (not) Positive_regulation (increased) of SCs in T24
10) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.08 Pain Relevance 0.03
In addition, we have shown that IL-6 is intimately associated with the SC response by a reporting a significant increase in IL-6 protein content within SCs at T4 and T24, coinciding with an increase in Pax7+ cell number at T24 and an increase in the percentage of Pax7+ cells actively proliferating (evidenced by an increased percentage Pax7+ cells expressing PCNA).
Positive_regulation (increase) of SCs in T24
11) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.09 Pain Relevance 0.07
Muscle specific stem cells, named satellite cells (SCs), are necessary for muscle repair and regeneration and are known to reside in skeletal muscle between the basal lamina and the sarcolemma.
Positive_regulation (necessary) of SCs in Muscle
12) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.18 Pain Relevance 0
In the rats with PAG microdialysis, the GABA level decreased significantly following two stimulation periods, although transitional increases during SCS were noted in some animals.
Positive_regulation (increases) of SCS in SCS associated with gaba, urological neuroanatomy and spinal cord
13) Confidence 0.06 Published 1993 Journal Stereotact Funct Neurosurg Section Abstract Doc Link 7531360 Disease Relevance 0.30 Pain Relevance 1.18
These include embryonic and fetal SCs, induced pluripotent cells, annex SCs, endogenous liver SCs, and extrahepatic adult SCs.
Positive_regulation (induced) of SCs in SCs
14) Confidence 0.06 Published 2010 Journal Stem Cells International Section Abstract Doc Link PMC2963137 Disease Relevance 0.24 Pain Relevance 0
These include embryonic and fetal SCs, induced pluripotent cells, annex SCs, endogenous liver SCs, and extrahepatic adult SCs.
Positive_regulation (induced) of SCs in SCs
15) Confidence 0.06 Published 2010 Journal Stem Cells International Section Abstract Doc Link PMC2963137 Disease Relevance 0.24 Pain Relevance 0
These include embryonic and fetal SCs, induced pluripotent cells, annex SCs, endogenous liver SCs, and extrahepatic adult SCs.
Positive_regulation (induced) of SCs in SCs
16) Confidence 0.06 Published 2010 Journal Stem Cells International Section Abstract Doc Link PMC2963137 Disease Relevance 0.24 Pain Relevance 0
When notch1a and notch3 are activated in epidermal SCs, the Notch signal is then mediated by Su(H) to activate the unknown member of bHLH-O in inhibiting expression of the pro-differentiating factors of ascl1a and foxi3a(3b) in the epidermal SC side.
Positive_regulation (activated) of SCs in Notch
17) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1810426 Disease Relevance 0 Pain Relevance 0

General Comments

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