INT48882

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Context Info
Confidence 0.46
First Reported 1994
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 5.12
Pain Relevance 7.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN3B)
Anatomy Link Frequency
brain 1
GRIN3B (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 26 100.00 Very High Very High Very High
gABA 13 100.00 Very High Very High Very High
Pain 10 100.00 Very High Very High Very High
nMDA receptor antagonist 6 100.00 Very High Very High Very High
opiate 2 100.00 Very High Very High Very High
Opioid 40 99.76 Very High Very High Very High
hyperexcitability 4 99.52 Very High Very High Very High
antagonist 26 98.84 Very High Very High Very High
Morphine 15 98.64 Very High Very High Very High
Glutamate 14 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 5 98.44 Very High Very High Very High
Pain 5 98.04 Very High Very High Very High
Alcohol Addiction 35 97.24 Very High Very High Very High
Neurological Disease 3 97.16 Very High Very High Very High
Nociception 4 96.88 Very High Very High Very High
Hemiplegia 1 94.36 High High
Hyperalgesia 8 94.04 High High
Deafness 1 93.88 High High
Hypersensitivity 5 93.84 High High
Systemic Lupus Erythematosus 84 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The putative anti-addictive drug ibogaine is a competitive inhibitor of [3H]MK-801 binding to the NMDA receptor complex.
NMDA receptor Binding (binding) of associated with nmda receptor
1) Confidence 0.46 Published 1994 Journal Psychopharmacology (Berl.) Section Title Doc Link 7531855 Disease Relevance 0.10 Pain Relevance 0.40
NMDA receptor antagonists: interactions with opioids.
NMDA receptor Binding (interactions) of associated with nmda receptor antagonist and opioid
2) Confidence 0.46 Published 1997 Journal Acta Anaesthesiol Scand Section Title Doc Link 9061093 Disease Relevance 0.66 Pain Relevance 1.29
The differential response to morphine administered pre- or postinjury may be relevant to the recently shown NMDA receptor mediated interaction of central hyperexcitability and morphine antinociception.
NMDA receptor Binding (interaction) of associated with antinociception, nmda receptor, hyperexcitability and morphine
3) Confidence 0.34 Published 2000 Journal Pain Section Abstract Doc Link 10812259 Disease Relevance 0.78 Pain Relevance 1.53
The differential effects observed on the recruitment curve and wind-up indicate, however, that the mechanisms of the interaction between opiates and NMDA receptor antagonists are not univocal but depend on the modality of activation of the nociceptive afferents.
NMDA receptor Binding (interaction) of associated with nociception, nmda receptor antagonist and opiate
4) Confidence 0.34 Published 2002 Journal Pain Section Abstract Doc Link 12098616 Disease Relevance 0.24 Pain Relevance 0.82
The NMDA receptor has been widely investigated in recent years as a target for the pharmacological management of seizures, pain and a variety of neurological disorders.
NMDA receptor Binding (target) of associated with pain, neurological disease, convulsion and nmda receptor
5) Confidence 0.27 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 12075105 Disease Relevance 0.45 Pain Relevance 0.42
Thus, the ethanol stimulus is composed of the several components, with the NMDA receptor and GABA(A) receptor complex being of particular importance.
NMDA receptor Binding (complex) of associated with gaba and nmda receptor
6) Confidence 0.27 Published 1999 Journal Alcohol Section Abstract Doc Link 9895039 Disease Relevance 0 Pain Relevance 0.70
Finally, the authors cite the progress achieved in the development of agents that interact with the glutamatergic system: NMDA channel blockers, competitive NMDA receptor antagonists, NR2B-selective antagonists, glutamate release inhibitors, glycineB antagonists, AMPA and kainate receptor antagonists, AMPA receptor-positive modulators and agents that act by modifying endogenous kynurenic acid metabolism.
NMDA receptor Binding (interact) of associated with glutamate, nmda receptor antagonist and antagonist
7) Confidence 0.11 Published 1998 Journal Drug News Perspect. Section Abstract Doc Link 15616669 Disease Relevance 1.34 Pain Relevance 0.70
Recent data suggest that acamprosate may interact with a polyamine site on the NMDA receptor complex and differentially modulate the activity of the receptor on the basis of existing polyamine levels.[33–35] In addition, there is evidence of action at an additional binding site on the metabotropic mGluR5 receptor;[36] this receptor has been implicated in addictive processes, modulates glutaminergic neurotransmission and interacts with the NMDA receptor.
NMDA receptor Binding (interact) of associated with nmda receptor
8) Confidence 0.05 Published 2007 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2899994 Disease Relevance 0.24 Pain Relevance 0.72
Recent data suggest that acamprosate may interact with a polyamine site on the NMDA receptor complex and differentially modulate the activity of the receptor on the basis of existing polyamine levels.[33–35] In addition, there is evidence of action at an additional binding site on the metabotropic mGluR5 receptor;[36] this receptor has been implicated in addictive processes, modulates glutaminergic neurotransmission and interacts with the NMDA receptor.
NMDA receptor Binding (interacts) of associated with nmda receptor
9) Confidence 0.05 Published 2007 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2899994 Disease Relevance 0.15 Pain Relevance 0.63
They have also examined whether any changes in the brain can be linked to the presence of autoantibodies that recognize a protein called the NMDA receptor (anti-NMDAR antibodies) that is present on brain cells.


NMDA receptor Binding (recognize) of in brain associated with nmda receptor
10) Confidence 0.01 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1702559 Disease Relevance 1.15 Pain Relevance 0.45

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