INT48883

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Context Info
Confidence 0.54
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 14.53
Pain Relevance 11.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN3B)
Anatomy Link Frequency
neuronal 2
spinal cord 2
neurons 1
GRIN3B (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 262 100.00 Very High Very High Very High
Glutamate 238 100.00 Very High Very High Very High
nMDA receptor antagonist 17 100.00 Very High Very High Very High
ketamine 112 99.90 Very High Very High Very High
methadone 4 99.84 Very High Very High Very High
antagonist 11 99.28 Very High Very High Very High
Face pain 2 99.08 Very High Very High Very High
Neuropathic pain 16 99.04 Very High Very High Very High
Opioid 26 98.64 Very High Very High Very High
Spinal cord 2 97.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 21 99.56 Very High Very High Very High
Disease 131 99.40 Very High Very High Very High
Stress 493 99.20 Very High Very High Very High
Injury 166 99.16 Very High Very High Very High
Anxiety Disorder 133 99.08 Very High Very High Very High
Facial Pain 2 99.08 Very High Very High Very High
Neuropathic Pain 22 99.04 Very High Very High Very High
Opiate Addiction 4 98.88 Very High Very High Very High
Post-traumatic Stress Disorder 528 97.52 Very High Very High Very High
Pain 65 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, inhibition of the NMDA receptor by high-affinity antagonists also blocks the receptor's normal function in synaptic transmission and leads to unacceptable side effects.
Negative_regulation (inhibition) of NMDA receptor associated with antagonist and nmda receptor
1) Confidence 0.54 Published 2007 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 17678953 Disease Relevance 0.89 Pain Relevance 0.31
In this case, in contrast to PDI or parkin, S-nitrosylation proves to be neuroprotective by decreasing excessive NMDA receptor activity.
Negative_regulation (decreasing) of NMDA receptor associated with nmda receptor
2) Confidence 0.54 Published 2007 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 17678953 Disease Relevance 0.71 Pain Relevance 0.29
As a result, memantine blocks excessive NMDA receptor activity without disrupting normal activity.
Negative_regulation (blocks) of NMDA receptor associated with nmda receptor
3) Confidence 0.54 Published 2007 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 17678953 Disease Relevance 0.64 Pain Relevance 0.31
In addition, considerable decrease in the up-regulated state of the NR3B subunit by methadone may represent another benefit of methadone therapy for opioid addicts and may serve as a suitable marker to evaluate the successfulness of therapy.
Negative_regulation (decrease) of NR3B subunit associated with methadone and opioid
4) Confidence 0.51 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20153313 Disease Relevance 0.32 Pain Relevance 1.25
Magnesium is known to block the NMDA receptor.
Negative_regulation (block) of NMDA receptor associated with nmda receptor
5) Confidence 0.51 Published 2000 Journal J Pain Symptom Manage Section Abstract Doc Link 10687324 Disease Relevance 1.02 Pain Relevance 1.09
Since MK-801 can attenuate the development of tolerance to morphine and alcohol as well as sensitization to stimulants in preclinical studies, the reported ability of ibogaine to modify drug-seeking behavior in man may be attributable to a blockade of NMDA receptor coupled cation channels.
Negative_regulation (blockade) of NMDA receptor associated with nmda receptor, tolerance, alcohol and morphine
6) Confidence 0.41 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7531855 Disease Relevance 0.08 Pain Relevance 0.40
In fact, blockade of excessive NMDA receptor activity can in large measure protect neurons from this type of injury and death.
Negative_regulation (blockade) of NMDA receptor in neurons associated with nmda receptor, injury and death
7) Confidence 0.40 Published 2007 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 17678953 Disease Relevance 0.92 Pain Relevance 0.30
With the absence of significant CNS side effects, the ketamine infusion not only demonstrated the well-documented spinal cord mechanism of the NMDA receptor, but the result of the current study also suggests that a peripheral mechanism of NMDA receptor may exist.
Negative_regulation (mechanism) of NMDA receptor in spinal cord associated with ketamine, nmda receptor and spinal cord
8) Confidence 0.37 Published 2001 Journal Pain Section Abstract Doc Link 11240090 Disease Relevance 1.09 Pain Relevance 1.65
Considerable interest was renewed in ketamine with the discovery that it could block the NMDA receptor and therefore it has a potential role in the management of windup and prevention of subsequent spinal cord sensitisation.
Negative_regulation (block) of NMDA receptor in spinal cord associated with ketamine, nmda receptor and spinal cord
9) Confidence 0.31 Published 2005 Journal BMC Anesthesiol Section Body Doc Link PMC1084341 Disease Relevance 0.16 Pain Relevance 0.86
Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain.
Negative_regulation (inhibitor) of NMDA receptor associated with ketamine, face pain and nmda receptor
10) Confidence 0.24 Published 1995 Journal Pain Section Title Doc Link 7659431 Disease Relevance 0.75 Pain Relevance 1.44
One potential explanation for this beneficial effect is the inhibition of NMDA receptor activation.
Negative_regulation (inhibition) of NMDA receptor associated with nmda receptor
11) Confidence 0.11 Published 2006 Journal Br J Anaesth Section Abstract Doc Link 16299047 Disease Relevance 0.29 Pain Relevance 0.36
This finding suggests that increased D-serine metabolism resulting from increased DAAO activity may produce a reduction in NMDA receptor activity.
Negative_regulation (reduction) of NMDA receptor associated with nmda receptor
12) Confidence 0.05 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 0.85 Pain Relevance 0.17
Accordingly, decreasing NMDA receptor function by administering NMDA receptor antagonists such as ketamine and phencyclidine (PCP) produced psychotomimetic symptoms, negative symptoms and cognitive deficits in animals and normal human subjects [21-23].
Negative_regulation (decreasing) of NMDA receptor associated with cognitive disorder, nmda receptor antagonist, ketamine and nmda receptor
13) Confidence 0.05 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 0.99 Pain Relevance 0.67
Despite the indication that overstimulation of the NMDA receptor might explain the neurodegeneration observed in PTSD, preclinical studies have found that inhibition of glutamate reuptake, resulting in increased glutamate levels, leads to a decrease in NMDA receptor density (Cebers et al 1999).
Negative_regulation (decrease) of NMDA receptor associated with glutamate, post-traumatic stress disorder and nmda receptor
14) Confidence 0.05 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.88 Pain Relevance 0.54
On the positive side, TDS stress-induced NOS activation has been found to result in a decrease in NMDA receptor density (Harvey et al 2004) that will adversely affect glutamate-driven LTP and consequent memory formation.
Negative_regulation (decrease) of NMDA receptor associated with stress, glutamate, nmda receptor and long-term potentiation
15) Confidence 0.05 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.64 Pain Relevance 0.37
The decrease in NMDA receptor density following TDS stress (Harvey et al 2004) further underlines the involvement of iNOS and not nNOS, since iNOS activation is not regulated by neuronal receptors (McCaslin and Oh 1995).


Negative_regulation (decrease) of NMDA receptor in neuronal associated with stress and nmda receptor
16) Confidence 0.04 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.95 Pain Relevance 0.24
For example, mice lacking a fully functional glutamate NMDA receptor are less sensitive to stress induced by the elevated plus-maze, light-dark box, and forced swimming tests (Miyamoto et al 2002).
Negative_regulation (lacking) of NMDA receptor associated with stress, glutamate and nmda receptor
17) Confidence 0.04 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.93 Pain Relevance 0.50
Since NO is able to down-regulate its own synthesis both directly on NOS (Griscavage et al 1995) and via down-regulation of the NMDA receptor (McCaslin and Oh 1995), these neuroprotective mechanisms may comprise a possible protective role for NO in the initial stages post stress.
Negative_regulation (down-regulation) of NMDA receptor associated with stress and nmda receptor
18) Confidence 0.04 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.75 Pain Relevance 0.23
Consequently, NMDA receptor antagonists (Padovan et al 2000), guanylate cyclase inhibitors (Eroglu and Caglayan 1997; Heiberg et al 2002), and NOS inhibitors (Volke, Wegener, Bourin, et al 2003) all demonstrate significant anxiolytic properties in animal models of anxiety.
Negative_regulation (inhibitors) of NMDA receptor associated with nmda receptor antagonist and anxiety disorder
19) Confidence 0.04 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.95 Pain Relevance 0.25
Preclinical pharmacological studies suggested that memantine blocks the NMDA receptor and prevents calcium influx when neuronal firing rates are high, but leaves the calcium channel relatively open for neurotransmission at low stimulation rates [46].
Negative_regulation (blocks) of NMDA receptor in neuronal associated with calcium channel and nmda receptor
20) Confidence 0.01 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647161 Disease Relevance 0.72 Pain Relevance 0.26

General Comments

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