INT48888

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Context Info
Confidence 0.29
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 5.04
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
stem cells 2
stromal cells 1
bone marrow 1
hematopoietic cells 1
Pbrgcsf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 132 100.00 Very High Very High Very High
Inflammation 57 100.00 Very High Very High Very High
chemokine 25 99.36 Very High Very High Very High
Pain 11 94.20 High High
anesthesia 3 88.24 High High
imagery 9 85.56 High High
Hippocampus 2 81.76 Quite High
ischemia 70 81.16 Quite High
palliative 1 78.92 Quite High
Angina 1 74.88 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 77 100.00 Very High Very High Very High
Lymphatic System Cancer 9 99.88 Very High Very High Very High
Myocardial Infarction 6 99.72 Very High Very High Very High
Disease 13 99.28 Very High Very High Very High
Neurodegenerative Disease 2 99.00 Very High Very High Very High
Sarcoma 1 97.36 Very High Very High Very High
Cancer 21 96.08 Very High Very High Very High
Pain 11 94.20 High High
Iron Overload 1 90.44 High High
Osteolysis 1 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Measurement of Serum EPO Levels in G-CSF-Treated Human Donors
Localization (Measurement) of G-CSF
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.25 Pain Relevance 0.04
We conducted a comparative study on a daily single versus a divided dose of G-CSF for G-CSF-induced mobilization of peripheral blood stem cells (PBSC) in eleven HLA-identical sibling donors of allogeneic PBSC transplantation (PBSCT).
Localization (mobilization) of G-CSF in stem cells
2) Confidence 0.25 Published 1997 Journal Int. J. Hematol. Section Abstract Doc Link 9277047 Disease Relevance 0.05 Pain Relevance 0
A cohort of 115 data-audited poor mobilizers in CUP was assessed, with the objective being to collect > or =2 x 10(6) CD34+ cells per kg following AMD3100 plus G-CSF mobilization.
Localization (mobilization) of G-CSF
3) Confidence 0.23 Published 2008 Journal Bone Marrow Transplant. Section Abstract Doc Link 17994119 Disease Relevance 1.09 Pain Relevance 0.14
Taken together, these experimental data suggest that EGCG selectively inhibits LPS-induced release of HMGB1, TNF, IL-6, IL-12, and chemokines, without affecting LPS-induced release of G-CSF, P-selection, LIX, IL-1?
Localization (release) of G-CSF associated with chemokine
4) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.07 Pain Relevance 0.28
Endogenous G-CSF and CD34+ cell mobilization after acute myocardial infarction.
Localization (mobilization) of G-CSF associated with myocardial infarction and cytokine
5) Confidence 0.20 Published 2006 Journal Int. J. Cardiol. Section Title Doc Link 16051386 Disease Relevance 0.45 Pain Relevance 0.17
Among the members of this family, IL-17A is the most studied, and it is secreted by activated T cells and acts on stromal cells to produce pro-inflammatory cytokines, such as GM-CSF, G-CSF, CXCL1, and CXCL8 (IL-8) [44].
Localization (secreted) of G-CSF in stromal cells associated with inflammation and cytokine
6) Confidence 0.10 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.44 Pain Relevance 0.58
Hurdles to be overcome include: a) reduced angiogenic potential of autologous cells in aged patients with cardiovascular risk factors; b) invasiveness/adverse effects of bone marrow extraction and G-CSF mobilization, respectively; and c) need for on-site cellular manipulation.
Localization (mobilization) of G-CSF in bone marrow
7) Confidence 0.10 Published 2008 Journal J Transl Med Section Abstract Doc Link PMC2533293 Disease Relevance 0.59 Pain Relevance 0.22
Allogeneic donors are generally mobilized with daily subcutaneous injections of G-CSF 10 microg/kg for 5 days.
Localization (mobilized) of G-CSF
8) Confidence 0.09 Published 2005 Journal Transfus. Apher. Sci. Section Abstract Doc Link 15737875 Disease Relevance 0.25 Pain Relevance 0.19
PBSC were collected using a continuous flow cell separator, COBE Spectra, after mobilization with chemotherapy followed by cytokine: rhGM-CSF and rhG-CSF s.c. (35 patients) or rhG-CSF s.c. alone (75 patients).
Localization (s.c.) of rhG-CSF in PBSC associated with cytokine
9) Confidence 0.06 Published 1996 Journal Bone Marrow Transplant. Section Abstract Doc Link 8932838 Disease Relevance 0.13 Pain Relevance 0.14
The goal of globin gene therapy is to offer a potentially curative treatment to patients lacking a matched, related donor, based on the transfer of a regulated beta-globin gene in autologous CD34+ hematopoietic cells collected following G-CSF mobilization.
Localization (mobilization) of G-CSF in hematopoietic cells
10) Confidence 0.06 Published 2009 Journal Hemoglobin Section Abstract Doc Link 20001625 Disease Relevance 0.63 Pain Relevance 0.08
[Paget disease, complicated by Ki-1 lymphoma with G-CSF growth factor secretion].
Localization (secretion) of G-CSF associated with lymphatic system cancer and disease
11) Confidence 0.06 Published 1994 Journal Rev Rhum Ed Fr Section Title Doc Link 7532068 Disease Relevance 1.09 Pain Relevance 0.21

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