INT4889

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Context Info
Confidence 0.35
First Reported 1992
Last Reported 1997
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.89
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (Ppt1) Golgi apparatus (Ppt1) cytosol (Ppt1)
extracellular space (Ppt1) protein modification process (Ppt1) extracellular region (Ppt1)
Anatomy Link Frequency
NAc 2
neurons 2
DRG 2
Ppt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 6 99.84 Very High Very High Very High
Nucleus accumbens 4 98.92 Very High Very High Very High
Arthritis 3 98.40 Very High Very High Very High
substance P 2 98.32 Very High Very High Very High
Inflammation 3 96.64 Very High Very High Very High
Eae 1 93.96 High High
Sciatic nerve 1 92.56 High High
Opioid 1 90.40 High High
Neuropeptide 4 89.84 High High
Dopamine 1 83.52 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 1 98.68 Very High Very High Very High
Arthritis 3 98.40 Very High Very High Very High
INFLAMMATION 2 96.64 Very High Very High Very High
Injury 2 93.12 High High
Neuropathic Pain 2 75.00 Quite High
Ganglion Cysts 1 75.00 Quite High
Neurogenic Inflammation 1 71.92 Quite High
Pain 1 70.80 Quite High
Body Weight 1 65.48 Quite High
Causalgia 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The experiments described in the present study approached nerve injury from both a biochemical and anatomical perspective by monitoring changes in expression of preprotachykinin (PPT) mRNA encoding the prototypic tachykinin substance P and related peptide species in neurons of the rat dorsal root ganglia (DRG) following unilateral chronic constriction injury of the sciatic nerve.
Regulation (changes) of Transcription (expression) of PPT in neurons associated with nervous system injury, eae, injury, sciatic nerve and substance p
1) Confidence 0.35 Published 1994 Journal Pain Section Abstract Doc Link 7816489 Disease Relevance 0.41 Pain Relevance 0.25
PPT-A mRNA expression was not significantly affected by caffeine treatment in the CPu or NAc.
Neg (not) Regulation (affected) of Transcription (expression) of PPT in NAc associated with nucleus accumbens
2) Confidence 0.26 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9280160 Disease Relevance 0.07 Pain Relevance 0.40
There were no changes in the proportion of DRG neurones expressing PPT or CGRP mRNAs.
Neg (no) Regulation (changes) of Transcription (expressing) of PPT in DRG associated with calcitonin gene-related peptide
3) Confidence 0.19 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1281253 Disease Relevance 0.41 Pain Relevance 0.69

General Comments

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