INT48890

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Context Info
Confidence 0.77
First Reported 1994
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 91
Total Number 93
Disease Relevance 28.62
Pain Relevance 31.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
neurons 19
skin 8
adult kidney 5
brain 4
sensory neurons 4
Gdnf (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 969 100.00 Very High Very High Very High
nociceptor 527 100.00 Very High Very High Very High
Inflammation 223 100.00 Very High Very High Very High
qutenza 125 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
c fibre 417 99.96 Very High Very High Very High
Thermal hyperalgesia 46 99.96 Very High Very High Very High
Acupuncture 14 99.84 Very High Very High Very High
Morphine 46 99.76 Very High Very High Very High
Desipramine 11 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Necrosis 599 100.00 Very High Very High Very High
Cancer 11 100.00 Very High Very High Very High
Hyperalgesia 74 99.96 Very High Very High Very High
Targeted Disruption 509 99.88 Very High Very High Very High
Hypersensitivity 146 99.28 Very High Very High Very High
Parkinson's Disease 1149 99.08 Very High Very High Very High
Neuropathic Pain 106 98.92 Very High Very High Very High
Toxicity 226 98.88 Very High Very High Very High
Diabetes Mellitus 97 98.68 Very High Very High Very High
INFLAMMATION 229 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To elucidate the functional properties of GDNF-dependent nociceptors and distinguish them from nociceptors that retain NGF dependence, the cellular and physiologic properties of sensory neurons of wild-type and transgenic mice that overexpress GDNF in the skin (GDNF-OE) were analyzed using a skin, nerve, dorsal root ganglion, and spinal cord preparation, immunolabeling, and reverse transcriptase-PCR assays.
Gene_expression (overexpress) of GDNF in skin associated with ganglion cysts, targeted disruption, dorsal root ganglion, addiction, nerve growth factor, nociceptor and spinal cord
1) Confidence 0.77 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16540576 Disease Relevance 0.20 Pain Relevance 0.79
These data indicate that enhanced expression of GDNF in the skin can change mechanical sensitivity of IB4-positive nociceptive afferents and that this may occur through enhanced expression of specific types of channel proteins.
Gene_expression (expression) of GDNF in IB4 associated with nociception
2) Confidence 0.77 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16540576 Disease Relevance 0.22 Pain Relevance 0.47
To elucidate the functional properties of GDNF-dependent nociceptors and distinguish them from nociceptors that retain NGF dependence, the cellular and physiologic properties of sensory neurons of wild-type and transgenic mice that overexpress GDNF in the skin (GDNF-OE) were analyzed using a skin, nerve, dorsal root ganglion, and spinal cord preparation, immunolabeling, and reverse transcriptase-PCR assays.
Gene_expression (overexpress) of GDNF-OE in skin associated with ganglion cysts, targeted disruption, dorsal root ganglion, addiction, nerve growth factor, nociceptor and spinal cord
3) Confidence 0.77 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16540576 Disease Relevance 0.20 Pain Relevance 0.79
Moreover, we mentioned the potential of Leu-Ile, which induces the expression of GDNF and TNF-alpha, as a novel therapeutic agent for drug dependence.
Gene_expression (expression) of GDNF associated with drug dependence and addiction
4) Confidence 0.75 Published 2007 Journal J. Pharmacol. Sci. Section Abstract Doc Link 17538232 Disease Relevance 0.80 Pain Relevance 0.93
Using pure cultures of striatal neurons we could
               establish that activation of mGlu3 receptors enhanced GDNF production by stimulating
               the MAPK and the PI-3-K pathways. 
Gene_expression (production) of GDNF in neurons
5) Confidence 0.72 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0 Pain Relevance 0.07
One of these factors, neurturin, is expressed in the epidermis, whereas its GDNF family receptor alpha2 (GFRalpha2) is expressed in the majority of unmyelinated Ret-positive sensory neurons.
Gene_expression (expressed) of GDNF in sensory neurons associated with unmyelinated
6) Confidence 0.70 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16481427 Disease Relevance 0.57 Pain Relevance 0.42
We have previously demonstrated that Leu-Ile, which induces the expression of not only tumor necrosis factor-alpha (TNF-alpha) but also glial cell line-derived neurotrophic factor (GDNF), inhibits methamphetamine (METH) and morphine (MOR)-induced sensitization and rewarding effects by regulating extracellular dopamine levels via the induction of TNF-alpha expression, and indicated the potential of Leu-Ile as a novel therapeutic agent for METH and MOR-induced dependence.
Gene_expression (expression) of GDNF in glial cell associated with addiction, necrosis, dopamine, cancer and morphine
7) Confidence 0.67 Published 2007 Journal Behav. Brain Res. Section Abstract Doc Link 17331595 Disease Relevance 0.30 Pain Relevance 0.71
Repeated treatment with MOR for 9 days, which results in an enhancement of the locomotor-stimulating effects (sensitization) of MOR, increased GDNF levels in the nucleus accumbens compared with those in saline-treated mice.
Gene_expression (levels) of GDNF in nucleus accumbens associated with nucleus accumbens and morphine
8) Confidence 0.67 Published 2007 Journal Behav. Brain Res. Section Abstract Doc Link 17331595 Disease Relevance 0.30 Pain Relevance 1.09
Furthermore, in some rare instances, injected hAFSC cells could express human Glial Derived Neurotrophic Factor (GDNF), which is expressed during very early kidney development; GDNF is not usually detectable in the adult kidney, indicating that injected hAFSC can express also embryonic renal markers, retaining the ability of going through the nephrogenesis.
Gene_expression (express) of GDNF in adult kidney
9) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827539 Disease Relevance 0.25 Pain Relevance 0
The use
               of brain-permeant drugs that mimic the action of GDNF or enhance the production of
               endogenous GDNF is an attractive strategy that may overcome the limitations
               associated with an invasive delivery of GDNF into the brain. 
Gene_expression (production) of GDNF in brain
10) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.38 Pain Relevance 0.14
The in situ hybridization procedure was used to examine the
                   expression of GDNF mRNAs in the striatum. 
Spec (examine) Gene_expression (expression) of GDNF in striatum
11) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0 Pain Relevance 0.07
GDNF and
               other GDNF-family ligands, such as neurturin, artemin, and persephin, belong to the
               TGF-? 
Gene_expression (belong) of GDNF
12) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0 Pain Relevance 0.08
Doses of LY379268 that are effective in enhancing GDNF levels protect
                   nigro-striatal neurons against MPTP toxicity in mice
Gene_expression (levels) of GDNF in neurons associated with parkinson's disease and toxicity
13) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.34 Pain Relevance 0.04
GDNF and
               other GDNF-family ligands, such as neurturin, artemin, and persephin, belong to the
               TGF-? 
Gene_expression (belong) of GDNF
14) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0 Pain Relevance 0.08
GDNF and NGF probe labelling and in situ hybridization
Gene_expression (labelling) of GDNF associated with nerve growth factor
15) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.27 Pain Relevance 0.18
MPTP
                   alone did not change GDNF levels at 1 day, but enhanced GDNF levels at 2 and 3
                   days, perhaps as a result of reactive gliosis (see above). 
Gene_expression (levels) of GDNF associated with parkinson's disease and gliosis
16) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.41 Pain Relevance 0.03
Activation of mGlu3 receptors enhances GDNF levels in cultured striatal
                   neurons (but not in astrocytes) via the activation of the MAP kinase and the
                   phosphatidylinositol-3-kinase pathways
Gene_expression (levels) of GDNF in neurons
17) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.29 Pain Relevance 0
GDNF and NGF probe labelling and in situ hybridization
Gene_expression (probe) of GDNF associated with nerve growth factor
18) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.27 Pain Relevance 0.18
Double labelling analysis by
                   combined in situ hybridization and immunohistochemistry (GDNF
                   mRNA+NeuN or GFAP) showed that GDNF is expressed in neurons (Fig. 5A) and treatment with
                   LY379268 (0.25 mg/kg, i.p., 3 h) selectively increased GDNF mRNA levels in
                   neurons (not shown). 
Gene_expression (expressed) of GDNF in neurons
19) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.22 Pain Relevance 0.03
Leu-Ile inhibits METH- or MOR-induced place preference and sensitization by attenuating the METH- or MOR-induced increase in extracellular dopamine levels in the nucleus accumbens via the induction of GDNF and TNF-alpha expression.
Gene_expression (expression) of GDNF in nucleus accumbens associated with nucleus accumbens, dopamine and morphine
20) Confidence 0.58 Published 2007 Journal J. Pharmacol. Sci. Section Abstract Doc Link 17538232 Disease Relevance 0.69 Pain Relevance 0.95

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