INT48891

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2011
Negated 4
Speculated 1
Reported most in Body
Documents 143
Total Number 144
Disease Relevance 101.42
Pain Relevance 56.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
plasma 16
lung 5
blood 4
sciatic nerve 4
Lymphocytes 3
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 1471 100.00 Very High Very High Very High
Inflammation 1458 100.00 Very High Very High Very High
Hyperalgesia 211 100.00 Very High Very High Very High
anesthesia 74 100.00 Very High Very High Very High
cva 54 99.98 Very High Very High Very High
Eae 577 99.90 Very High Very High Very High
Multiple sclerosis 53 99.88 Very High Very High Very High
rheumatoid arthritis 208 99.84 Very High Very High Very High
Traumatic nerve injury 22 99.84 Very High Very High Very High
qutenza 24 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1577 100.00 Very High Very High Very High
Hyperalgesia 320 100.00 Very High Very High Very High
Hemorrhage 98 99.98 Very High Very High Very High
Injury 972 99.90 Very High Very High Very High
Demyelinating Disease 40 99.88 Very High Very High Very High
Obesity 167 99.86 Very High Very High Very High
Rheumatoid Arthritis 209 99.84 Very High Very High Very High
Lymphatic System Cancer 122 99.82 Very High Very High Very High
Acute Coronary Syndrome 12 99.82 Very High Very High Very High
Myocardial Infarction 27 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase of IL-10 protein and mRNA were 1.5- and 3-fold, respectively, compared to that in morphine-infused rat spinal cords.
Positive_regulation (increase) of IL-10 in spinal cords associated with morphine
1) Confidence 0.70 Published 2010 Journal Behav. Brain Res. Section Abstract Doc Link 19799935 Disease Relevance 0.25 Pain Relevance 2.00
Significant changes of IL-10 protein levels were also induced in C7-C8 DRG by the unilateral CCI of the sciatic nerve.
Positive_regulation (induced) of IL-10 in sciatic nerve associated with eae and sciatic nerve
2) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.62 Pain Relevance 0.43
Unilateral CCI of the sciatic nerve induced a significant bilateral increase of IL-10 protein level in L4-L5 DRG as early as 1 day from the operation.
Positive_regulation (increase) of IL-10 in sciatic nerve associated with eae and sciatic nerve
3) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.64 Pain Relevance 0.45
This possibility is supported by later bilateral elevation of IL-10 in the lumbar DRG (14 days from sham operation) while CCI induced bilateral increase already after 1 day.
Positive_regulation (elevation) of IL-10 associated with eae
4) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.55 Pain Relevance 0.27
protein in both the lumbar and cervical DRG was induced by unilateral CCI of the sciatic nerve for 7 and 14 days, while the level of IL-10 protein was increased bilaterally in the lumbar DRG 1 and 3 days after CCI and in the ipsilateral cervical DRG 3 days from operation.
Positive_regulation (increased) of IL-10 in sciatic nerve associated with eae and sciatic nerve
5) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.75 Pain Relevance 0.66
Also plasma IL-1beta and IL-10 were elevated with maximal value at the first and second day after ischemia, respectively.
Positive_regulation (elevated) of IL-10 in plasma associated with ischemia
6) Confidence 0.68 Published 2001 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11453102 Disease Relevance 1.13 Pain Relevance 0.37
Animals undergoing more severe ligation strains exhibited significantly heightened allodynia following injury and greater upregulation of the inflammatory cytokines IL-1alpha/beta, IL-6, and IL-10.
Positive_regulation (upregulation) of IL-10 associated with inflammation, allodynia, injury, sprains and strains and cytokine
7) Confidence 0.67 Published 2001 Journal J. Neurosci. Methods Section Abstract Doc Link 11574119 Disease Relevance 1.53 Pain Relevance 0.65
Thalidomide treatment in chronic constrictive neuropathy decreases endoneurial tumor necrosis factor-alpha, increases interleukin-10 and has long-term effects on spinal cord dorsal horn met-enkephalin.
Positive_regulation (increases) of interleukin-10 in spinal cord dorsal horn associated with necrosis, cancer, neuropathic pain, dorsal horn, enkephalin and spinal cord
8) Confidence 0.66 Published 2000 Journal Pain Section Title Doc Link 11068114 Disease Relevance 1.07 Pain Relevance 0.69
Interleukin-10 is induced in the CNS in a number of disease conditions [54].
Positive_regulation (induced) of Interleukin-10 associated with central nervous system and disease
9) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.22 Pain Relevance 1.01
IL-10 remained increased until day 3 in the hypothermia group.
Positive_regulation (increased) of IL-10 associated with hypothermia
10) Confidence 0.62 Published 2002 Journal Shock Section Abstract Doc Link 12069191 Disease Relevance 1.22 Pain Relevance 0.12
RESULTS: CIP was manifested by an increase in plasma levels of amylase, lipase, leptin and an anti-inflammatory interleukin 10 (IL-10), (by 400%, 1000%, 700% and 50%, respectively), confirmed by histological examination and accompanied by 40% reduction in pancreatic blood flow.
Positive_regulation (increase) of interleukin 10 in blood
11) Confidence 0.61 Published 2002 Journal Med. Sci. Monit. Section Body Doc Link 11951059 Disease Relevance 0.17 Pain Relevance 0
RESULTS: CIP was manifested by an increase in plasma levels of amylase, lipase, leptin and an anti-inflammatory interleukin 10 (IL-10), (by 400%, 1000%, 700% and 50%, respectively), confirmed by histological examination and accompanied by 40% reduction in pancreatic blood flow.
Positive_regulation (increase) of IL-10 in blood
12) Confidence 0.61 Published 2002 Journal Med. Sci. Monit. Section Body Doc Link 11951059 Disease Relevance 0.17 Pain Relevance 0
LPS resulted in significant reduction of CIP accompanied by dose-dependent increase in plasma levels of leptin and IL-10.
Positive_regulation (increase) of IL-10 in plasma
13) Confidence 0.61 Published 2002 Journal Med. Sci. Monit. Section Body Doc Link 11951059 Disease Relevance 0.14 Pain Relevance 0
The induction of IL-10 correlated with the suppression of TNF and iNOS suggests that IL-10 may play a role in downregulating TNF and iNOS in septic rats undergoing laparotomy and laparoscopy.
Positive_regulation (induction) of IL-10
14) Confidence 0.60 Published 2002 Journal Surg Laparosc Endosc Percutan Tech Section Abstract Doc Link 12193819 Disease Relevance 0.60 Pain Relevance 0.17
Inhibition of tumor necrosis factor-alpha and inducible nitric oxide synthase correlates with the induction of IL-10 in septic rats undergoing laparotomy and laparoscopy.
Positive_regulation (induction) of IL-10 associated with necrosis and cancer
15) Confidence 0.60 Published 2002 Journal Surg Laparosc Endosc Percutan Tech Section Title Doc Link 12193819 Disease Relevance 0.81 Pain Relevance 0.20
Speculatively we infer that a high level of IL-10 was associated to TNF generation in order to opposite the inflammatory effects of TNF on lung inflammation.
Positive_regulation (level) of IL-10 in lung associated with inflammation and pneumonia
16) Confidence 0.57 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 1.08 Pain Relevance 0.27
In addition, IL-10 levels increased in lung cells of OVx allergic rats upon estradiol treatment.
Positive_regulation (increased) of IL-10 in lung associated with hypersensitivity
17) Confidence 0.57 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 1.19 Pain Relevance 0.29
The elevated TNFalpha, IL-1beta and NF-kappaB in brain were accordingly reduced, while the expression of increased IL-10 were even stimulated after repeated mirtazapine administration.
Positive_regulation (increased) of IL-10 in brain
18) Confidence 0.57 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18248895 Disease Relevance 0.65 Pain Relevance 0.91
Small-dose capsaicin treatment increased antiinflammatory IL-10 levels and attenuated the increases in proinflammatory cytokines, NOx, and tissue MDA in septic rats.
Positive_regulation (increased) of IL-10 associated with inflammation, qutenza and cytokine
19) Confidence 0.56 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15502055 Disease Relevance 0.65 Pain Relevance 0.74
In the SLC group, plasma concentrations of TNF-alpha, IL-6, NOx, and tissue MDA levels were reduced and IL-10 level was increased when compared with groups S and SHC 18 h after CLP (P < 0.05).
Positive_regulation (increased) of IL-10 in CLP
20) Confidence 0.56 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15502055 Disease Relevance 0.67 Pain Relevance 0.76

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