INT48892

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Context Info
Confidence 0.71
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 31
Total Number 32
Disease Relevance 27.26
Pain Relevance 16.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
T cells 3
blood 2
sciatic nerves 2
peripheral nervous system 2
mononuclear cell 2
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 234 100.00 Very High Very High Very High
Inflammation 182 100.00 Very High Very High Very High
antagonist 3 100.00 Very High Very High Very High
Neuropathic pain 26 99.86 Very High Very High Very High
gABA 8 99.78 Very High Very High Very High
Neuritis 69 99.66 Very High Very High Very High
Peripheral nervous system 13 99.52 Very High Very High Very High
Spinal cord 11 99.28 Very High Very High Very High
adenocard 5 99.28 Very High Very High Very High
Multiple sclerosis 28 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 185 100.00 Very High Very High Very High
Cancer 19 100.00 Very High Very High Very High
Necrosis 18 100.00 Very High Very High Very High
Neuropathic Pain 55 99.86 Very High Very High Very High
Pressure And Volume Under Development 55 99.84 Very High Very High Very High
Experimental Autoimmune Neuritis 45 99.66 Very High Very High Very High
Wallerian Degeneration 16 99.64 Very High Very High Very High
Myasthenia Gravis 4 99.22 Very High Very High Very High
Acrodermatitis 5 99.10 Very High Very High Very High
Demyelinating Disease 33 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of the tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta) and interleukin 10 (IL-10) mRNA in the tissue were estimated by reverse transcription-polymerase chain reaction (RT-PCR).
Transcription (levels) of interleukin 10 associated with necrosis and cancer
1) Confidence 0.71 Published 2009 Journal Phytother Res Section Abstract Doc Link 19067390 Disease Relevance 1.09 Pain Relevance 0.64
The levels of the tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta) and interleukin 10 (IL-10) mRNA in the tissue were estimated by reverse transcription-polymerase chain reaction (RT-PCR).
Transcription (levels) of IL-10 associated with necrosis and cancer
2) Confidence 0.71 Published 2009 Journal Phytother Res Section Abstract Doc Link 19067390 Disease Relevance 1.09 Pain Relevance 0.64
In this model, HT-20 appears to decrease pro-inflammatory cytokines IL-1beta and TNF-alpha and not to increase the antiinflammatory cytokine mRNA expression of IL-10.
Transcription (expression) of IL-10 associated with inflammation and cytokine
3) Confidence 0.71 Published 2009 Journal Phytother Res Section Abstract Doc Link 19067390 Disease Relevance 0.93 Pain Relevance 0.56
Contrastingly, infiltrating macrophages expressed IL-10 mRNA conincident with beginning clinical recovery in experimental autoimmune neuritis (EAN), the rat model of human Guillain-Barré syndrome.
Transcription (expressed) of IL-10 mRNA in macrophages associated with syndrome, experimental autoimmune neuritis and neuritis
4) Confidence 0.69 Published 1996 Journal J. Neurosci. Res. Section Abstract Doc Link 8820973 Disease Relevance 0.61 Pain Relevance 0.63
This study examined the time course of mRNA levels of the proinflammatory cytokines interferon-gamma (IFNgamma), interleukin-1beta (IL1beta), interleukin-12 (IL12; p40 subunit), and the immunosuppressant interleukin-10 (IL10) by semiquantitative reverse transcription polymerase chain reaction (RT-PCR) in rats with actively induced experimental autoimmune neuritis (EAN) and in distal stumps of crushed sciatic nerves undergoing Wallerian degeneration.
Transcription (levels) of IL10 in sciatic nerves associated with experimental autoimmune neuritis, wallerian degeneration, sciatic nerve, neuritis and cytokine
5) Confidence 0.69 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9514202 Disease Relevance 0.59 Pain Relevance 0.51
Sequential expression of mRNA for proinflammatory cytokines and interleukin-10 in the rat peripheral nervous system: comparison between immune-mediated demyelination and Wallerian degeneration.
Transcription (expression) of interleukin-10 in peripheral nervous system associated with demyelination, peripheral nervous system, wallerian degeneration and cytokine
6) Confidence 0.69 Published 1998 Journal J. Neurosci. Res. Section Title Doc Link 9514202 Disease Relevance 0.59 Pain Relevance 0.76
This study examined the time course of mRNA levels of the proinflammatory cytokines interferon-gamma (IFNgamma), interleukin-1beta (IL1beta), interleukin-12 (IL12; p40 subunit), and the immunosuppressant interleukin-10 (IL10) by semiquantitative reverse transcription polymerase chain reaction (RT-PCR) in rats with actively induced experimental autoimmune neuritis (EAN) and in distal stumps of crushed sciatic nerves undergoing Wallerian degeneration.
Transcription (levels) of interleukin-10 in sciatic nerves associated with experimental autoimmune neuritis, wallerian degeneration, sciatic nerve, neuritis and cytokine
7) Confidence 0.69 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9514202 Disease Relevance 0.59 Pain Relevance 0.51
In order to further analyze the role of these T cells and their corresponding cytokines in EAN, we studied the expression of mRNA for IFN-gamma, IL-4, and IL-10 in the cauda equina of rats with EAN using a quantitative competitive reverse transcriptase PCR method.
Transcription (expression) of IL-10 in T cells associated with neuritis and cytokine
8) Confidence 0.62 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9628467 Disease Relevance 1.11 Pain Relevance 0.65
To study the role of key pro- and anti-inflammatory cytokines in a chronic constriction model of neuropathic pain, mRNA expression of TNF, IL-1beta, IL-6, and IL-10 was quantified using competitive RT-PCR.
Transcription (expression) of IL-10 associated with inflammation, neuropathic pain and cytokine
9) Confidence 0.60 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11358451 Disease Relevance 0.77 Pain Relevance 0.90
In conclusion, the observed polymorphisms, resulting in low IL-10 and high IL-4 gene transcription, could favor a T helper (Th)-2 mediated antibody response to neoantigenic stimulation associated with disease susceptibility.
Transcription (transcription) of IL-10 associated with disease susceptibility
10) Confidence 0.57 Published 2004 Journal Hepatology Section Abstract Doc Link 15122773 Disease Relevance 0.68 Pain Relevance 0.36
Differential expression of interleukin-10 mRNA in Wallerian degeneration and immune-mediated inflammation of the rat peripheral nervous system.
Transcription (expression) of interleukin-10 in peripheral nervous system associated with peripheral nervous system, inflammation and wallerian degeneration
11) Confidence 0.53 Published 1996 Journal J. Neurosci. Res. Section Title Doc Link 8820973 Disease Relevance 0.56 Pain Relevance 0.58
A subsequent sharp decline of IL-10 protein below the baseline level of the naïve DRG was found in L4-L5 DRG of both sides, but more so in the ipsilateral ones.
Transcription (found) of IL-10
12) Confidence 0.52 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.75 Pain Relevance 0.52
mRNA transcription by IL-10 and glial inhibitors would be consistent with their antihyperalgesic effect.
Transcription (transcription) of IL-10 associated with antihyperalgesic
13) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.97 Pain Relevance 0.94
In a model of spinal immune activation by intrathecal HIV-1 gp120, we show that the anti-allodynic effects of minocycline are associated with decreased microglial activation, attenuated mRNA expression of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), IL-1beta-converting enzyme, TNF-alpha-converting enzyme, IL-1 receptor antagonist and IL-10 in lumbar dorsal spinal cord, and reduced IL-1beta and TNF-alpha levels in the CSF.
Transcription (expression) of IL-10 in dorsal associated with necrosis, cancer, antagonist, acquired immune deficiency syndrome or hiv infection, spinal cord and intrathecal
14) Confidence 0.43 Published 2005 Journal Pain Section Abstract Doc Link 15836971 Disease Relevance 1.34 Pain Relevance 1.32
Intraperitoneal administration of O2 and O3 did not have a significant impact on IL-10 levels after 24 h of observation.
Transcription (levels) of IL-10
15) Confidence 0.36 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827707 Disease Relevance 0.60 Pain Relevance 0.12
Increased mRNA expression for IFN-gamma and TNF-alpha was registered correlating with the peak of clinical signs of EAN, and high levels of mRNA expression for IL-4, IL-10, and TGF-beta were associated with EAN recovery.
Transcription (expression) of IL-10 associated with neuritis
16) Confidence 0.35 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530887 Disease Relevance 1.09 Pain Relevance 1.14
Th1 cytokine (IL-2 and interferon-gamma) production and mRNA expression in splenic T cells of traumatized rats were significantly decreased on postoperative day 3 (P < 0.001, trauma group versus control group), whereas Th2 cytokine (IL-4 and IL-10) production and mRNA expression were increased (P < 0.001).
Transcription (expression) of IL-10 in T cells
17) Confidence 0.30 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843806 Disease Relevance 0 Pain Relevance 0
Splenic T cells were isolated and the production and mRNA expression of interleukin (IL)-2, interferon-gamma, IL-4, and IL-10 were assayed.
Transcription (expression) of IL-10 in T cells
18) Confidence 0.30 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843806 Disease Relevance 0 Pain Relevance 0
These include genes encoding GAD65 GABA synthesis enzyme, anti-inflammatory cytokine, IL-10, and GABAB1d, A1 adenosine, ?
Transcription (enzyme) of IL-10 associated with adenocard, gaba, inflammation and cytokine
19) Confidence 0.29 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.65 Pain Relevance 0.72
To study the potential role of cytokines in context with cytokine autoantibodies (Aabs) in EAN, we used in situ hybridization to detect mRNA expression of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, IL-4, IL-10, and transforming growth factor (TGF)-beta in lymph node mononuclear cell (MNC) and in sciatic nerve sections, as well as ELISA for detection of their autoantibodies in sera and cerebrospinal fluid (CSF) over the course of EAN.
Transcription (expression) of IL-10 in mononuclear cell associated with necrosis, cancer, sciatic nerve, neuritis and cytokine
20) Confidence 0.26 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530887 Disease Relevance 1.13 Pain Relevance 1.01

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