INT48893

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 4.29
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
blood 2
mononuclear cells 2
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 14 100.00 Very High Very High Very High
Neuritis 22 99.78 Very High Very High Very High
Inflammation 11 99.10 Very High Very High Very High
Multiple sclerosis 14 99.00 Very High Very High Very High
Sciatic nerve 1 89.68 High High
Hyperalgesia 4 75.00 Quite High
Peripheral nervous system 1 70.72 Quite High
anesthesia 1 67.44 Quite High
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 11 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 10 99.78 Very High Very High Very High
Demyelinating Disease 15 99.00 Very High Very High Very High
Optic Neuritis 12 98.58 Very High Very High Very High
Pressure And Volume Under Development 2 90.96 High High
Necrosis 2 84.36 Quite High
Cancer 2 84.00 Quite High
Myasthenia Gravis 2 82.12 Quite High
Hyperalgesia 4 75.00 Quite High
Syndrome 1 73.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this model, HT-20 appears to decrease pro-inflammatory cytokines IL-1beta and TNF-alpha and not to increase the antiinflammatory cytokine mRNA expression of IL-10.
Neg (not) Positive_regulation (increase) of Transcription (expression) of IL-10 associated with inflammation and cytokine
1) Confidence 0.69 Published 2009 Journal Phytother Res Section Abstract Doc Link 19067390 Disease Relevance 1.00 Pain Relevance 0.57
Increased mRNA expression for IFN-gamma and TNF-alpha was registered correlating with the peak of clinical signs of EAN, and high levels of mRNA expression for IL-4, IL-10, and TGF-beta were associated with EAN recovery.
Positive_regulation (levels) of Transcription (expression) of IL-10 associated with neuritis
2) Confidence 0.24 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530887 Disease Relevance 1.10 Pain Relevance 1.15
Increased mRNA expression of IL-10 in mononuclear cells in multiple sclerosis and optic neuritis.
Positive_regulation (Increased) of Transcription (expression) of IL-10 in mononuclear cells associated with multiple sclerosis, optic neuritis and neuritis
3) Confidence 0.18 Published 1995 Journal Scand. J. Immunol. Section Title Doc Link 7532318 Disease Relevance 1.02 Pain Relevance 0.72
ON patients examined within 1 month after onset had lower numbers of MBP induced IL-10 mRNA expressing blood MNC compared with patients examined later suggesting that IL-10 is related to the degree of inflammation and outcome in ON.
Spec (examined) Positive_regulation (induced) of Transcription (expressing) of IL-10 in blood associated with inflammation and neuritis
4) Confidence 0.12 Published 1995 Journal Scand. J. Immunol. Section Abstract Doc Link 7532318 Disease Relevance 1.18 Pain Relevance 0.85

General Comments

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