INT48894

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.26
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.79
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
TMJ 4
dorsal 2
blood 2
lymphoid tissue 2
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 65 100.00 Very High Very High Very High
antagonist 1 100.00 Very High Very High Very High
Spinal cord 3 99.28 Very High Very High Very High
Multiple sclerosis 7 98.96 Very High Very High Very High
intrathecal 2 97.56 Very High Very High Very High
Neuritis 6 93.44 High High
Pain 7 92.52 High High
allodynia 4 83.16 Quite High
Inflammation 6 75.84 Quite High
Sciatic nerve 1 74.44 Quite High
Disease Link Frequency Relevance Heat
Necrosis 2 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Demyelinating Disease 7 98.96 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 97.64 Very High Very High Very High
Optic Neuritis 6 93.44 High High
Pain 7 92.52 High High
Myasthenia Gravis 1 89.44 High High
Neuropathic Pain 6 83.16 Quite High
INFLAMMATION 6 75.84 Quite High
Sepsis 37 65.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a model of spinal immune activation by intrathecal HIV-1 gp120, we show that the anti-allodynic effects of minocycline are associated with decreased microglial activation, attenuated mRNA expression of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), IL-1beta-converting enzyme, TNF-alpha-converting enzyme, IL-1 receptor antagonist and IL-10 in lumbar dorsal spinal cord, and reduced IL-1beta and TNF-alpha levels in the CSF.
Negative_regulation (attenuated) of Transcription (expression) of IL-10 in dorsal associated with necrosis, cancer, antagonist, acquired immune deficiency syndrome or hiv infection, spinal cord and intrathecal
1) Confidence 0.26 Published 2005 Journal Pain Section Abstract Doc Link 15836971 Disease Relevance 1.35 Pain Relevance 1.33
PN is associated with a rapid fall in lymphocyte cell counts and a change in cell profiles in gut-associated lymphoid tissue; this profile change is related to decreased levels of the Th2 cytokines IL-4 and IL-10 [23].
Negative_regulation (decreased) of Transcription (levels) of IL-10 in lymphoid tissue associated with cytokine
2) Confidence 0.18 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.12 Pain Relevance 0.11
Numbers of IL-10 mRNA expressing MNC were elevated in the MS patients' blood both when enumerated without culture and after culture with MBP.
Negative_regulation (Numbers) of Transcription (expressing) of IL-10 in blood associated with multiple sclerosis
3) Confidence 0.11 Published 1995 Journal Scand. J. Immunol. Section Abstract Doc Link 7532318 Disease Relevance 1.10 Pain Relevance 0.78
Furthermore, an inflammatory response characterised by the predominant expression of IL12 mRNA and down-regulated expression of IL10 mRNA is associated with the degenerative changes observed in OA-TMJ.


Negative_regulation (down) of Transcription (expression) of IL10 in TMJ
4) Confidence 0.07 Published 2008 Journal Arch. Oral Biol. Section Body Doc Link 18508030 Disease Relevance 0.11 Pain Relevance 0
Furthermore, an inflammatory response characterised by the predominant expression of IL12 mRNA and down-regulated expression of IL10 mRNA is associated with the degenerative changes observed in OA-TMJ.


Negative_regulation (regulated) of Transcription (expression) of IL10 in TMJ
5) Confidence 0.07 Published 2008 Journal Arch. Oral Biol. Section Body Doc Link 18508030 Disease Relevance 0.11 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox