INT48895

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2011
Negated 2
Speculated 10
Reported most in Abstract
Documents 333
Total Number 347
Disease Relevance 221.20
Pain Relevance 138.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
mononuclear cells 16
plasma 16
blood 16
T cells 12
brain 11
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 3550 100.00 Very High Very High Very High
Inflammation 3096 100.00 Very High Very High Very High
antagonist 185 100.00 Very High Very High Very High
Inflammatory mediators 95 100.00 Very High Very High Very High
metalloproteinase 37 100.00 Very High Very High Very High
gABA 23 100.00 Very High Very High Very High
headache 25 99.92 Very High Very High Very High
Neuropathic pain 595 99.86 Very High Very High Very High
acular 3 99.86 Very High Very High Very High
rheumatoid arthritis 333 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3454 100.00 Very High Very High Very High
Cancer 504 100.00 Very High Very High Very High
Necrosis 255 100.00 Very High Very High Very High
Renal Cancer 49 99.98 Very High Very High Very High
Stress 850 99.92 Very High Very High Very High
Premature Birth 81 99.92 Very High Very High Very High
Headache 18 99.92 Very High Very High Very High
Repression 2 99.92 Very High Very High Very High
Neuropathic Pain 1232 99.86 Very High Very High Very High
Myocardial Infarction 69 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ultra-low dose naloxone upregulates interleukin-10 expression and suppresses neuroinflammation in morphine-tolerant rat spinal cords.
Gene_expression (expression) of interleukin-10 in spinal cords associated with narcan, cytokine and morphine
1) Confidence 0.78 Published 2010 Journal Behav. Brain Res. Section Title Doc Link 19799935 Disease Relevance 0.14 Pain Relevance 1.68
The vast majority of ED1-positive macrophages were IL-10 negative after axotomy.
Neg (negative) Gene_expression (negative) of IL-10 in macrophages
2) Confidence 0.78 Published 1996 Journal J. Neurosci. Res. Section Abstract Doc Link 8820973 Disease Relevance 0.58 Pain Relevance 0.61
During Wallerian degeneration, SCs strongly expressed IL-10 mRNA between days 2 and 4 after transection.
Gene_expression (expressed) of IL-10 mRNA in SCs associated with wallerian degeneration
3) Confidence 0.78 Published 1996 Journal J. Neurosci. Res. Section Abstract Doc Link 8820973 Disease Relevance 0.56 Pain Relevance 0.59
IL-10 mRNA was expressed by some Schwann cells (SCs) in the normal sciatic nerve.
Gene_expression (expressed) of IL-10 mRNA in Schwann cells associated with sciatic nerve
4) Confidence 0.78 Published 1996 Journal J. Neurosci. Res. Section Abstract Doc Link 8820973 Disease Relevance 0.53 Pain Relevance 0.56
and IL-10 protein levels in DRG heteronymous to injured nerve
Gene_expression (levels) of IL-10 in nerve
5) Confidence 0.76 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.82 Pain Relevance 0.41
It has been also proven that IL-10 is expressed predominantly in small-sized DRG neurons [38].
Gene_expression (expressed) of IL-10 in neurons
6) Confidence 0.76 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.88 Pain Relevance 0.64
and IL-10 protein levels in DRG of sham-operated rats
Gene_expression (levels) of IL-10
7) Confidence 0.76 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.47 Pain Relevance 0.23
Thus, gut-derived NE up-regulates IL-1beta and IL-10 expression and release in the liver through an alpha(2)-AR pathway.
Gene_expression (expression) of IL-10 in gut
8) Confidence 0.76 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15949713 Disease Relevance 0.12 Pain Relevance 0.23
Co-administration of NE and YHB, however, significantly attenuated IL-1beta and IL-10 production.
Gene_expression (production) of IL-10
9) Confidence 0.76 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15949713 Disease Relevance 0.14 Pain Relevance 0.24
The gene expression of IL-1beta and IL-10 in KC and their supernatant levels were assessed.
Gene_expression (expression) of IL-10
10) Confidence 0.76 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15949713 Disease Relevance 0.22 Pain Relevance 0.23
Similarly, IL-1beta and IL-10 gene expression and release from KC were up-regulated by NE stimulation, whereas YHB attenuated both cytokines.
Gene_expression (expression) of IL-10 associated with cytokine
11) Confidence 0.76 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15949713 Disease Relevance 0.14 Pain Relevance 0.24
Since thalidomide mainly inhibits tumor necrosis factor alpha (TNF-alpha) synthesis with less well defined effects on other cytokines, we investigated the effect of the drug on the expression of the proinflammatory cytokines TNF-alpha, interleukin-1beta (IL-1beta) and interleukin 6 (IL-6), and of the anti-inflammatory cytokine interleukin-10 (IL-10) in the lesioned rat sciatic nerve.
Gene_expression (expression) of IL-10 in sciatic nerve associated with necrosis, inflammation, cancer, sciatic nerve and cytokine
12) Confidence 0.74 Published 2000 Journal Pain Section Abstract Doc Link 11068114 Disease Relevance 1.04 Pain Relevance 0.65
Gene expression of TGFbeta, IL-1beta, IFNgamma, IL10 and alpha-SMA was quantitated by real-time (RT)-PCR in the peri-implant tissue.
Gene_expression (expression) of IL10
13) Confidence 0.73 Published 2010 Journal J Biomater Sci Polym Ed Section Abstract Doc Link 20534192 Disease Relevance 0.34 Pain Relevance 0.25
CONCLUSIONS: These results suggest that the antiinflammatory effect of amitriptyline on morphine tolerance, probably acting by increasing IL-10 expression, is mediated by p38 mitogen-activated protein kinase heme oxygenase-1 signal transduction cascade.


Gene_expression (expression) of IL-10
14) Confidence 0.73 Published 2009 Journal Anesthesiology Section Body Doc Link 19417613 Disease Relevance 0 Pain Relevance 0
RESULTS: Amitriptyline/morphine coinfusion upregulated IL-10 protein expression in microglia; this was not observed in morphine-infused rats.
Gene_expression (expression) of IL-10 in microglia
15) Confidence 0.73 Published 2009 Journal Anesthesiology Section Body Doc Link 19417613 Disease Relevance 0.07 Pain Relevance 0
Anti-IL-10 antibody effectively neutralized the amitriptyline-induced IL-10 expression in chronic morphine-infused rats.
Gene_expression (expression) of IL-10
16) Confidence 0.73 Published 2009 Journal Anesthesiology Section Body Doc Link 19417613 Disease Relevance 0.07 Pain Relevance 0
NF-kappaB activation in the brain was investigated by an electrophoretic mobility shift assay (EMSA), and cerebral expressions of tumor necrosis factor-alpha (TNFalpha), interleukin-1beta (IL-1beta), and interleukin-10 (IL-10) were quantified using enzyme-linked immunosorbent assays (ELISA).
Gene_expression (expressions) of IL-10 in brain associated with necrosis and cancer
17) Confidence 0.72 Published 2006 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 16501235 Disease Relevance 0.90 Pain Relevance 0.70
In addition, betamethasone reduced the activation of NF-kappaB and elevation of TNFalpha and IL-1beta, and induced the expression of IL-10 in the brain, all of which correlated with the changes of pain thresholds in rats.
Gene_expression (expression) of IL-10 in brain associated with pain
18) Confidence 0.72 Published 2006 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 16501235 Disease Relevance 0.90 Pain Relevance 0.87
NF-kappaB activation in the brain was investigated by an electrophoretic mobility shift assay (EMSA), and cerebral expressions of tumor necrosis factor-alpha (TNFalpha), interleukin-1beta (IL-1beta), and interleukin-10 (IL-10) were quantified using enzyme-linked immunosorbent assays (ELISA).
Gene_expression (expressions) of interleukin-10 in brain associated with necrosis and cancer
19) Confidence 0.72 Published 2006 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 16501235 Disease Relevance 0.89 Pain Relevance 0.70
Betamethasone may act by regulating the expression of NF-kappaB, TNFalpha, IL-1beta and IL-10 in the brain.
Gene_expression (expression) of IL-10 in brain
20) Confidence 0.72 Published 2006 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 16501235 Disease Relevance 0.84 Pain Relevance 0.86

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