INT48896

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 73
Total Number 77
Disease Relevance 43.14
Pain Relevance 35.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
brain 14
PBMC 12
T cell 8
plasma 4
spinal nerve 4
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 629 100.00 Very High Very High Very High
Inflammation 622 100.00 Very High Very High Very High
gABA 8 100.00 Very High Very High Very High
fluoxetine 28 99.98 Very High Very High Very High
narcan 11 99.98 Very High Very High Very High
Multiple sclerosis 40 99.68 Very High Very High Very High
intrathecal 104 99.66 Very High Very High Very High
qutenza 18 99.64 Very High Very High Very High
Thermal hyperalgesia 54 99.58 Very High Very High Very High
Pain 118 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 658 100.00 Very High Very High Very High
Cancer 99 100.00 Very High Very High Very High
Necrosis 44 100.00 Very High Very High Very High
Demyelinating Disease 27 99.68 Very High Very High Very High
Hyperalgesia 86 99.58 Very High Very High Very High
Experimental Arthritis 52 99.42 Very High Very High Very High
Experimental Autoimmune Neuritis 29 99.30 Very High Very High Very High
Cv Unclassified Under Development 34 98.94 Very High Very High Very High
Primary Sclerosing Cholangitis 6 98.88 Very High Very High Very High
Injury 261 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ultra-low dose naloxone upregulates interleukin-10 expression and suppresses neuroinflammation in morphine-tolerant rat spinal cords.
Positive_regulation (upregulates) of Gene_expression (expression) of interleukin-10 in spinal cords associated with narcan, cytokine and morphine
1) Confidence 0.70 Published 2010 Journal Behav. Brain Res. Section Title Doc Link 19799935 Disease Relevance 0.14 Pain Relevance 1.68
CONCLUSIONS: These results suggest that the antiinflammatory effect of amitriptyline on morphine tolerance, probably acting by increasing IL-10 expression, is mediated by p38 mitogen-activated protein kinase heme oxygenase-1 signal transduction cascade.


Positive_regulation (increasing) of Gene_expression (expression) of IL-10
2) Confidence 0.66 Published 2009 Journal Anesthesiology Section Body Doc Link 19417613 Disease Relevance 0 Pain Relevance 0
Anti-IL-10 antibody effectively neutralized the amitriptyline-induced IL-10 expression in chronic morphine-infused rats.
Positive_regulation (induced) of Gene_expression (expression) of IL-10
3) Confidence 0.66 Published 2009 Journal Anesthesiology Section Body Doc Link 19417613 Disease Relevance 0.07 Pain Relevance 0
RESULTS: Amitriptyline/morphine coinfusion upregulated IL-10 protein expression in microglia; this was not observed in morphine-infused rats.
Positive_regulation (upregulated) of Gene_expression (expression) of IL-10 in microglia
4) Confidence 0.66 Published 2009 Journal Anesthesiology Section Body Doc Link 19417613 Disease Relevance 0.08 Pain Relevance 0
In addition, betamethasone reduced the activation of NF-kappaB and elevation of TNFalpha and IL-1beta, and induced the expression of IL-10 in the brain, all of which correlated with the changes of pain thresholds in rats.
Positive_regulation (induced) of Gene_expression (expression) of IL-10 in brain associated with pain
5) Confidence 0.64 Published 2006 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 16501235 Disease Relevance 0.90 Pain Relevance 0.87
These findings suggest that the antiinflammatory and analgesic mechanisms of baicalin may be associated with the inhibition of critical inflammatory mediators, including nitric oxide, PGE(2), and proinflammatory cytokines, accompanied by an increase in IL-10 production, as well as neutrophil infiltration at sites of inflammation.
Positive_regulation (increase) of Gene_expression (production) of IL-10 in neutrophil associated with inflammatory mediators, inflammation, analgesic and cytokine
6) Confidence 0.58 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14633550 Disease Relevance 0.64 Pain Relevance 0.73
Furthermore, baicalin dose-dependently attenuated tumor necrosis factor-alpha (from 3510 +/- 150 pg/mL to 2860 +/- 148 pg/mL to 1480 +/- 210 pg/mL), interleukin (IL)-1beta (from 3210 +/- 210 pg/mL to 2200 +/- 140 pg/mL to 750 +/- 95 pg/mL), and IL-6 (from 58.5 +/- 9.8 pg/mL to 38.5 +/- 9.0 to 21.0 +/- 8.1 ng/mL) formation but enhanced IL-10 (from 18.1 +/- 2.5 pg/mL to 36.1 +/- 5.5 pg/mL to 71.2 +/- 9.5 pg/mL) production in paw exudates at 4 h after carrageenan injection.
Positive_regulation (enhanced) of Gene_expression (production) of IL-10 in paw associated with necrosis and cancer
7) Confidence 0.58 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14633550 Disease Relevance 0.55 Pain Relevance 0.44
The elevated TNFalpha, IL-1beta and NF-kappaB in brain were accordingly reduced, while the expression of increased IL-10 were even stimulated after repeated mirtazapine administration.
Positive_regulation (increased) of Gene_expression (expression) of IL-10 in brain
8) Confidence 0.57 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18248895 Disease Relevance 0.66 Pain Relevance 0.91
Stimulated production of tumor necrosis factor alpha, interleukin 10, and interleukin 1beta in whole blood cultures was measured by enzyme-linked immunosorbent assay.
Positive_regulation (Stimulated) of Gene_expression (production) of interleukin 10 in blood
9) Confidence 0.56 Published 2006 Journal Anesthesiology Section Body Doc Link 16810004 Disease Relevance 0.15 Pain Relevance 0
On the other hand, ischemia/reperfusion-enhanced renal interleukin (IL)-10 mRNA expression and plasma concentrations of IL-10 were augmented by treatment with capsaicin in ARF rats.
Positive_regulation (augmented) of Gene_expression (expression) of IL-10 in plasma associated with acute renal failure, qutenza and ischemia
10) Confidence 0.55 Published 2008 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 18460982 Disease Relevance 1.41 Pain Relevance 0.98
A single epidural injection of betamethasone at the time of nerve injury partially inhibited the development of neuropathic hyperalgesia and reduced the subsequent elevated levels of pro-inflammatory cytokines in the brain, while stimulating the expression of the anti-inflammatory cytokine IL-10.
Positive_regulation (stimulating) of Gene_expression (expression) of cytokine IL-10 in brain associated with hyperalgesia, nervous system injury, inflammation, neuropathic pain, epidural and cytokine
11) Confidence 0.52 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16253423 Disease Relevance 1.49 Pain Relevance 1.31
In the present study the expression of IL-10 mRNA increased rapidly in proximal and distal sections at 24 hours after injury both in the endo- and epi/perineurium, most likely as an inhibitory response to inflammatory reactions that TNF-?
Positive_regulation (increased) of Gene_expression (expression) of IL-10 mRNA in perineurium associated with inflammation and injury
12) Confidence 0.52 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1310517 Disease Relevance 0.61 Pain Relevance 0.07
Thus, gut-derived NE up-regulates IL-1beta and IL-10 expression and release in the liver through an alpha(2)-AR pathway.
Positive_regulation (up-regulates) of Gene_expression (expression) of IL-10 in gut
13) Confidence 0.49 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15949713 Disease Relevance 0.13 Pain Relevance 0.24
Similarly, IL-1beta and IL-10 gene expression and release from KC were up-regulated by NE stimulation, whereas YHB attenuated both cytokines.
Positive_regulation (up-regulated) of Gene_expression (expression) of IL-10 associated with cytokine
14) Confidence 0.49 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15949713 Disease Relevance 0.14 Pain Relevance 0.24
Both repeated and single administration of BLF suppressed TNF-alpha production and increased IL-10 production in the LPS-stimulated adjuvant arthritis rats.
Positive_regulation (increased) of Gene_expression (production) of IL-10 associated with experimental arthritis and arthritis
15) Confidence 0.46 Published 2004 Journal J. Vet. Med. Sci. Section Abstract Doc Link 15031542 Disease Relevance 1.16 Pain Relevance 0.97
The results indicate that serum levels of IL-1beta and IL-10 increased significantly after the intraportal infusion of NE.
Positive_regulation (increased) of Gene_expression (levels) of IL-10
16) Confidence 0.46 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15949713 Disease Relevance 0.21 Pain Relevance 0.25
We found that spinal nerve injury caused long-lasting mechanical and thermal hyperalgesia in the hind paw and stimulated the expression of NF-kappaB, TNFalpha, IL-1beta and IL-10 in the brain.
Positive_regulation (stimulated) of Gene_expression (expression) of IL-10 in spinal nerve associated with nervous system injury and thermal hyperalgesia
17) Confidence 0.43 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16253423 Disease Relevance 1.43 Pain Relevance 1.24
Thus, although we did not find association of periodontitis with the polymorphism evaluate, other polymorphisms in IL10 gene may be present and the possible haplotypes may contribute to the production of IL-10 differently.
Spec (may) Positive_regulation (contribute) of Gene_expression (production) of IL-10 associated with periodontitis
18) Confidence 0.43 Published 2009 Journal The Open Dentistry Journal Section Body Doc Link PMC2745565 Disease Relevance 0.56 Pain Relevance 0
Considering possible haplotypes, each polymorphism may contribute to the production of IL-10 differently and specific haplotypes may influence in progression of periodontal disease [28, 29].
Spec (may) Positive_regulation (contribute) of Gene_expression (production) of IL-10 associated with periodontal disease
19) Confidence 0.43 Published 2009 Journal The Open Dentistry Journal Section Body Doc Link PMC2745565 Disease Relevance 0.45 Pain Relevance 0.03
Furthermore, baicalin dose-dependently attenuated tumor necrosis factor-alpha (from 3510 +/- 150 pg/mL to 2860 +/- 148 pg/mL to 1480 +/- 210 pg/mL), interleukin (IL)-1beta (from 3210 +/- 210 pg/mL to 2200 +/- 140 pg/mL to 750 +/- 95 pg/mL), and IL-6 (from 58.5 +/- 9.8 pg/mL to 38.5 +/- 9.0 to 21.0 +/- 8.1 ng/mL) formation but enhanced IL-10 (from 18.1 +/- 2.5 pg/mL to 36.1 +/- 5.5 pg/mL to 71.2 +/- 9.5 pg/mL) production in paw exudates at 4 h after carrageenan injection.
Positive_regulation (enhanced) of Gene_expression (production) of IL-10 in paw associated with necrosis and cancer
20) Confidence 0.42 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14633550 Disease Relevance 0.55 Pain Relevance 0.44

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