INT4890

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Context Info
Confidence 0.77
First Reported 1989
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 51
Total Number 53
Disease Relevance 8.93
Pain Relevance 21.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (Ppt1) Golgi apparatus (Ppt1) cytosol (Ppt1)
extracellular space (Ppt1) protein modification process (Ppt1) extracellular region (Ppt1)
Anatomy Link Frequency
DRG 5
Acb 4
striatum 3
muscle 3
parabrachial nucleus 2
Ppt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 116 100.00 Very High Very High Very High
cocaine 14 99.98 Very High Very High Very High
Calcitonin gene-related peptide 33 99.84 Very High Very High Very High
antagonist 32 99.84 Very High Very High Very High
Nicotine 26 99.84 Very High Very High Very High
Nucleus accumbens 29 99.76 Very High Very High Very High
Pain 206 99.70 Very High Very High Very High
Dopamine 66 99.70 Very High Very High Very High
Locus ceruleus 242 99.68 Very High Very High Very High
parabrachial 4 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 190 99.70 Very High Very High Very High
Herpes Simplex Virus 9 99.70 Very High Very High Very High
INFLAMMATION 75 98.14 Very High Very High Very High
Hyperalgesia 165 96.84 Very High Very High Very High
Arthritis 14 96.72 Very High Very High Very High
Ganglion Cysts 10 95.36 Very High Very High Very High
Hypersensitivity 7 94.00 High High
Infection 5 92.56 High High
Neck Pain 6 90.40 High High
Nociception 68 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The ANOVA detected a significant interaction between intervention and time for PPT levels in the masseter muscle (F = 62.5; P < .001) and condyle (F = 50.4; P < .001), and pain-free active mouth opening (F = 34.9; P < .001).
Gene_expression (levels) of PPT in masseter
1) Confidence 0.77 Published 2010 Journal J Orofac Pain Section Body Doc Link 20213036 Disease Relevance 0.06 Pain Relevance 0
Also, we monitored the effects of the compound on preproenkephalin (PPE) and preprotachykinin (PPT) gene expression in rat striatum.
Gene_expression (expression) of PPT in striatum
2) Confidence 0.76 Published 2002 Journal Brain Res. Section Abstract Doc Link 12384245 Disease Relevance 0.08 Pain Relevance 0.16
Knife-cut lesions of the frontal cortical pole, transecting the prefrontal corticostriatal projection at the level of the foreceps minor, displayed little or no effect on the expression of either PPE or PPT mRNA in the dopamine-intact striatum.
Gene_expression (expression) of PPT mRNA in prefrontal associated with dopamine
3) Confidence 0.75 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7981878 Disease Relevance 0 Pain Relevance 0.29
The effects of knife-cut transections of the frontal cortical pole on the expression of PPE and PPT mRNA in rat striatal neurons was studied in intact striata and in striata previously denervated by a 6-hydroxydopamine (6-OHDA) lesion of the mesencephalic dopamine pathways.
Gene_expression (expression) of PPT mRNA in pole associated with dopamine
4) Confidence 0.75 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7981878 Disease Relevance 0 Pain Relevance 0.20
Thus, dopaminergic stimulation of the striatum could produce PPT disinhibition and result in non-specific cortical activation.
Gene_expression (produce) of PPT in striatum
5) Confidence 0.68 Published 2003 Journal Brain Res. Section Abstract Doc Link 12965227 Disease Relevance 0 Pain Relevance 0.13
Significant negative correlations between pain intensity and PPT levels were found.
Gene_expression (levels) of PPT associated with pain
6) Confidence 0.67 Published 2010 Journal Exp Brain Res Section Abstract Doc Link 20186400 Disease Relevance 0.81 Pain Relevance 0.80
RESULTS: The analysis of variance showed that PPT levels were significantly bilaterally decreased over both trigeminal (supra-orbital, infra-orbital, and mental) and nontrigeminal (median, ulnar, and radial) nerves in children with FETTH as compared with control subjects (all sites, P < .001).
Gene_expression (levels) of PPT in radial
7) Confidence 0.67 Published 2010 Journal Pediatrics Section Body Doc Link 20530075 Disease Relevance 0.08 Pain Relevance 0
The results showed that PPT levels were significantly decreased bilaterally over the masseter, temporalis, and upper trapezius muscles, and also the C5-C6 zygapophyseal joint (P < .001), but not over the tibialis anterior muscle (P = .4) in patients with mechanical chronic neck pain when compared to controls.
Gene_expression (levels) of PPT in muscles associated with pain and neck pain
8) Confidence 0.67 Published 2010 Journal J Pain Section Abstract Doc Link 19945351 Disease Relevance 0.82 Pain Relevance 0.82
The most sensitive localizations for PPT assessment correspond to the muscle belly of the extensor carpi radialis brevis.
Gene_expression (assessment) of PPT in extensor carpi radialis brevis
9) Confidence 0.66 Published 2010 Journal Med Sci Sports Exerc Section Body Doc Link 19996999 Disease Relevance 0 Pain Relevance 0
It is established that dopamine (DA) controls the expression of preprodynorphin (PPDYN), preprotachykinin A (PPT-A) and preproenkephalin (PPE) mRNAs in striatal structures.
Gene_expression (expression) of PPT associated with dopamine
10) Confidence 0.65 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9526067 Disease Relevance 0 Pain Relevance 0.43
Finally, the absence of any effect of 5-HT(2) antagonist on the expression of PPT-A mRNA in intact animals is discussed.
Gene_expression (expression) of PPT associated with antagonist
11) Confidence 0.65 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11754083 Disease Relevance 0 Pain Relevance 0.42
The precise role of 5-HT(2) receptor on PPT-A mRNA biosynthesis after a neonatal lesion should be clarified by further experiments using 5-HT(2) agonists.
Gene_expression (biosynthesis) of PPT associated with agonist
12) Confidence 0.65 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11754083 Disease Relevance 0 Pain Relevance 0.39
The effects of a repeated treatment with nicotine on the expression of mRNAs encoding preproenkephalin (PPE), preprotachykinin-A (PPT-A), and preprodynorphin (PPDYN) were examined by in situ hybridization histochemistry in various subregions of the nucleus accumbens (Acb).
Spec (examined) Gene_expression (expression) of PPT in Acb associated with nucleus accumbens and nicotine
13) Confidence 0.65 Published 1996 Journal Synapse Section Abstract Doc Link 8723714 Disease Relevance 0 Pain Relevance 0.28
PPT-A mRNA expression was not significantly affected by caffeine treatment in the CPu or NAc.
Gene_expression (expression) of PPT in NAc associated with nucleus accumbens
14) Confidence 0.65 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9280160 Disease Relevance 0.07 Pain Relevance 0.39
Altered PPT expression in the parabrachial nucleus may be involved in the altered pain processing seen in this model.
Gene_expression (expression) of PPT in parabrachial nucleus associated with pain and parabrachial
15) Confidence 0.61 Published 2008 Journal Brain Res. Section Abstract Doc Link 18440496 Disease Relevance 0.17 Pain Relevance 0.59
PPT expression in the lateral parabrachial nucleus also showed preshockxnoise interaction (up after noise in controls, higher basal and down after noise in preshocked), and was increased after noise in the periaquaeductal grey.
Gene_expression (expression) of PPT in parabrachial nucleus associated with parabrachial
16) Confidence 0.61 Published 2008 Journal Brain Res. Section Abstract Doc Link 18440496 Disease Relevance 0.34 Pain Relevance 0.50
Finally, PPT from the extensor digitorum muscle in those patients with active TrPs (mean+/-SD: 244+/-70.4 KPa) was significantly lower (P<0.001) than PPT levels of patients with no TrP in the same muscle (mean+/-SD: 370+/-83.4 KPa).
Gene_expression (levels) of PPT in muscle
17) Confidence 0.59 Published 2008 Journal Clin J Pain Section Body Doc Link 18936598 Disease Relevance 0 Pain Relevance 0
Effects of adjuvant-induced inflammation on the biosynthesis of substance P in the rat nervous system were examined by measuring the levels of mRNA encoding preprotachykinin A (PPT-A, the precursor protein of substance P).
Gene_expression (levels) of PPT in nervous system associated with inflammation and substance p
18) Confidence 0.58 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2469044 Disease Relevance 0.32 Pain Relevance 0.55
Repeated nicotine administration increases the PPE mRNA level in the rostral pole and the anterior third of the core without any change in PPT-A and PPDYN mRNA levels in the various Acb subregions examined.
Spec (examined) Gene_expression (levels) of PPT in Acb associated with nucleus accumbens and nicotine
19) Confidence 0.58 Published 1996 Journal Synapse Section Abstract Doc Link 8723714 Disease Relevance 0 Pain Relevance 0.47
Lesions of the dopaminergic striatal afferents resulted in marked increases in the mRNA encoding PPE throughout the striatum, including the ventral striatum and nucleus accumbens, while the levels of PPT mRNA were considerably reduced in these structures.
Gene_expression (levels) of PPT mRNA in striatum associated with nucleus accumbens
20) Confidence 0.58 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7981878 Disease Relevance 0 Pain Relevance 0.28

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