INT48902

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 29
Disease Relevance 17.91
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ACE2) extracellular space (ACE2) extracellular region (ACE2)
plasma membrane (ACE2)
Anatomy Link Frequency
placenta 3
smooth muscle 2
arterial endothelium 2
spike 2
endothelium 2
ACE2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 7 100.00 Very High Very High Very High
Inflammatory mediators 9 99.76 Very High Very High Very High
Inflammation 200 98.98 Very High Very High Very High
cytokine 44 98.64 Very High Very High Very High
Osteoarthritis 63 97.80 Very High Very High Very High
Arthritis 5 95.56 Very High Very High Very High
rheumatoid arthritis 7 92.00 High High
Chronic low back pain 2 86.48 High High
Analgesic 2 86.48 High High
cINOD 13 84.16 Quite High
Disease Link Frequency Relevance Heat
Severe Acute Respiratory Syndrome 537 100.00 Very High Very High Very High
Dengue Hemorrhagic Fever 410 100.00 Very High Very High Very High
Hypercalcemia 12 99.96 Very High Very High Very High
Pre-eclampsia 330 99.88 Very High Very High Very High
INFLAMMATION 223 99.36 Very High Very High Very High
Adhesions 3 99.24 Very High Very High Very High
Disease 407 99.16 Very High Very High Very High
Pulmonary Hypertension 248 99.16 Very High Very High Very High
Osteoarthritis 65 97.80 Very High Very High Very High
Necrosis 67 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To assess ACE2 expression in the vasculopathy patients, we tested for ACE2 by immunoprecipitation followed by immunoblotting.
Gene_expression (expression) of ACE2
1) Confidence 0.78 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 0 Pain Relevance 0
A plasmid DNA-encoding human ACE2 cDNA, which was kindly gifted from Dr Hyeryun Choe (Harvard Medical School, Cambridge, MA, USA), was introduced into 293 free-style cells, according to the manufacturer's protocol (Invitrogen, Carlsbad, CA, USA).
Gene_expression (cDNA) of ACE2
2) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 1.15 Pain Relevance 0.13
ELISA for serum anti-ACE2 antibodies
Gene_expression (antibodies) of ACE2
3) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 1.71 Pain Relevance 0.03
The signal intensities of ACE2 protein and the IgG heavy chain shown in Figure 3d were measured and normalized.


Gene_expression (measured) of ACE2 protein
4) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 0.31 Pain Relevance 0.06
As shown in Figure 3d, the ACE2 levels in Patients 1 and 5, who were deficient in ACE2 activity (Figure 3c), were comparable with those in three healthy subjects, clearly indicating that the decreased ACE2 activity in the vasculopathy patients was due to a functional deficiency.
Gene_expression (levels) of ACE2
5) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 0.12 Pain Relevance 0
The relative ACE2 protein levels in the patients are shown in Additional file 3.
Gene_expression (levels) of ACE2 protein
6) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 0.21 Pain Relevance 0.05
Detection of anti-ACE2 antibodies in patient serum
Gene_expression (antibodies) of ACE2
7) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 1.28 Pain Relevance 0.16
Recent studies have demonstrated the therapeutic effects of ACE2 activation by a synthetic molecule [5] or of ACE2 gene transfer [6] in experimental pulmonary hypertension models.
Gene_expression (transfer) of ACE2 associated with pulmonary hypertension
8) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911869 Disease Relevance 0.89 Pain Relevance 0.04
The novel vasodilatory components of the renin-angiotensin system, Ang-(1–7) and its generating enzyme ACE2 are expressed in syncytio and cytotrophoblast, endothelial cells, vascular smooth muscle of placental villi, interstitial and intraarterial trophoblast, in decidual cells, and in the endothelium and smooth muscle of the umbilical arteries.
Gene_expression (generating) of ACE2 in endothelium
9) Confidence 0.53 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.32 Pain Relevance 0.03
From day 14 onwards Ang-(1–7) and ACE2 are expressed in the labyrinthine placenta, and at day 19 are increased in the uterine wall and expressed in the placenta.
Gene_expression (expressed) of ACE2 in placenta
10) Confidence 0.53 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.08 Pain Relevance 0
In the guinea-pig Ang-(1–7) and ACE2 are expressed in the labyrinthine and interlobular placenta, in syncytial streamers, interstitial, perivascular and intravascular cytotrophoblasts; in contrast to other vasodilator factors, no expression of Ang-(1–7) and ACE2 have been detected in the subplacenta, providing evidence of a tight regulation of the peptide and its generating enzyme (Joyner, Brosnihan, Corthorn, unpublished observations),
Gene_expression (expressed) of ACE2 in placenta
11) Confidence 0.53 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.06 Pain Relevance 0
In the guinea-pig Ang-(1–7) and ACE2 are expressed in the labyrinthine and interlobular placenta, in syncytial streamers, interstitial, perivascular and intravascular cytotrophoblasts; in contrast to other vasodilator factors, no expression of Ang-(1–7) and ACE2 have been detected in the subplacenta, providing evidence of a tight regulation of the peptide and its generating enzyme (Joyner, Brosnihan, Corthorn, unpublished observations),
Neg (no) Gene_expression (expression) of ACE2 in placenta
12) Confidence 0.53 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.06 Pain Relevance 0
With the exception of an increased expression of ACE2 in umbilical arterial endothelium in preeclampsia, the expression of Ang-(1–7) and ACE2 is similar in different cell types in reproductive tissues from normal term or preeclamptic pregnancies.
Gene_expression (expression) of ACE2 in arterial endothelium associated with pre-eclampsia
13) Confidence 0.53 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.30 Pain Relevance 0
With the exception of an increased expression of ACE2 in umbilical arterial endothelium in preeclampsia, the expression of Ang-(1–7) and ACE2 is similar in different cell types in reproductive tissues from normal term or preeclamptic pregnancies.
Gene_expression (expression) of ACE2 in arterial endothelium associated with pre-eclampsia
14) Confidence 0.53 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.29 Pain Relevance 0
The low levels of Ang-(1–7) and ACE2 in the RUPP model may represent an inhibition of the vasodilator arm of the renin-angiotensin system associated with factors generated by the reduced placental blood flow (sFlt-1, TNF-?
Gene_expression (levels) of ACE2 in blood
15) Confidence 0.46 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.09 Pain Relevance 0
The novel vasodilatory components of the renin-angiotensin system, Ang-(1–7) and its generating enzyme ACE2 are expressed in syncytio and cytotrophoblast, endothelial cells, vascular smooth muscle of placental villi, interstitial and intraarterial trophoblast, in decidual cells, and in the endothelium and smooth muscle of the umbilical arteries.
Gene_expression (expressed) of ACE2 in endothelium
16) Confidence 0.41 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.31 Pain Relevance 0.03
Eight recombinant human single-chain variable region fragments (scFvs) against the S1 domain of spike (S) protein of the SARS-CoV from two nonimmune human antibody libraries were screened and one scFv 80R efficiently neutralized SARS-CoV and inhibited syncytia formation between cells expressing the S protein and those expressing the SARS-CoV receptor angiotensin-converting enzyme 2 (ACE2) [117].
Gene_expression (expressing) of ACE2 in spike associated with severe acute respiratory syndrome
17) Confidence 0.29 Published 2005 Journal Respir Res Section Body Doc Link PMC548145 Disease Relevance 1.24 Pain Relevance 0
SARS-CoV replicated efficiently on ACE2-transfected but not mock-transfected 293T cells.
Gene_expression (transfected) of ACE2 associated with severe acute respiratory syndrome
18) Confidence 0.29 Published 2005 Journal Respir Res Section Body Doc Link PMC548145 Disease Relevance 1.09 Pain Relevance 0
Eight recombinant human single-chain variable region fragments (scFvs) against the S1 domain of spike (S) protein of the SARS-CoV from two nonimmune human antibody libraries were screened and one scFv 80R efficiently neutralized SARS-CoV and inhibited syncytia formation between cells expressing the S protein and those expressing the SARS-CoV receptor angiotensin-converting enzyme 2 (ACE2) [117].
Gene_expression (expressing) of angiotensin-converting enzyme 2 in spike associated with severe acute respiratory syndrome
19) Confidence 0.25 Published 2005 Journal Respir Res Section Body Doc Link PMC548145 Disease Relevance 1.24 Pain Relevance 0
The novel vasodilatory components of the renin-angiotensin system, Ang-(1–7) and its generating enzyme ACE2 are expressed in syncytio and cytotrophoblast, endothelial cells, vascular smooth muscle of placental villi, interstitial and intraarterial trophoblast, in decidual cells, and in the endothelium and smooth muscle of the umbilical arteries.
Gene_expression (generating) of ACE2 in smooth muscle
20) Confidence 0.18 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.32 Pain Relevance 0.03

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