INT48907

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1995
Last Reported 2009
Negated 1
Speculated 4
Reported most in Abstract
Documents 53
Total Number 57
Disease Relevance 8.55
Pain Relevance 33.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
CHO 16
brain 12
neurons 8
spinal 4
preoptic area 3
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 182 100.00 Very High Very High Very High
Opioid 79 100.00 Very High Very High Very High
mu opioid receptor 75 100.00 Very High Very High Very High
agonist 39 100.00 Very High Very High Very High
Enkephalin 33 100.00 Very High Very High Very High
dexamethasone 16 100.00 Very High Very High Very High
Pain 16 100.00 Very High Very High Very High
Hyperalgesia 14 100.00 Very High Very High Very High
nociceptor 13 100.00 Very High Very High Very High
Rostral ventromedial medulla 7 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 18 100.00 Very High Very High Very High
Pain 11 100.00 Very High Very High Very High
Stress 7 99.98 Very High Very High Very High
Arthritis 4 99.96 Very High Very High Very High
Experimental Arthritis 26 99.04 Very High Very High Very High
INFLAMMATION 7 99.00 Very High Very High Very High
Diabetes Mellitus 10 98.92 Very High Very High Very High
Injury 8 98.48 Very High Very High Very High
Nociception 10 98.40 Very High Very High Very High
Anxiety Disorder 1 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased mu opioid receptor expression in the central amygdaloid nuclei suggests a decreased opioidergic tone at this level that could be involved in fluoxetine anorectic action.
Positive_regulation (Increased) of Gene_expression (expression) of mu opioid receptor associated with appetite loss, mu opioid receptor and fluoxetine
1) Confidence 0.69 Published 2006 Journal Int. J. Neurosci. Section Abstract Doc Link 16484055 Disease Relevance 0.34 Pain Relevance 0.61
OBJECTIVES: The aim of this study was to evaluate the antinociceptive and antidepressant-like effects and the possible variations in mu-opioid receptor expression induced by a chronic nefazodone treatment in brain areas related to pain and affective state.
Positive_regulation (induced) of Gene_expression (expression) of mu-opioid receptor in brain
2) Confidence 0.69 Published 2004 Journal Psychopharmacology (Berl.) Section Body Doc Link 15138764 Disease Relevance 0.09 Pain Relevance 0
Chronic antidepressants could act by increasing mu-opioid receptor expression in many brain areas involved in the regulation of nociception and affective state.
Positive_regulation (increasing) of Gene_expression (expression) of mu-opioid receptor in brain associated with nociception and opioid receptor
3) Confidence 0.69 Published 2004 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 15138764 Disease Relevance 0.53 Pain Relevance 0.74
CONCLUSION: Therefore, chronic nefazodone induces antinociceptive and antidepressant-like effects in rats and increases mu-opioid receptor expression in brain areas related to pain and affective state.
Positive_regulation (increases) of Gene_expression (expression) of mu-opioid receptor in brain
4) Confidence 0.69 Published 2004 Journal Psychopharmacology (Berl.) Section Body Doc Link 15138764 Disease Relevance 0 Pain Relevance 0
Striosomal mu receptor expression increased only slightly between postnatal day 5 and adult.
Positive_regulation (increased) of Gene_expression (expression) of Striosomal mu receptor
5) Confidence 0.69 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15860573 Disease Relevance 0 Pain Relevance 0.26
The level of mu-opioid receptor mRNA expression was significantly (p < 0.001) increased in neurons of animals killed at 20.00 h in comparison with the other hours of the day, i.e. 06.00 and 12.00 h.
Positive_regulation (increased) of Gene_expression (expression) of mu-opioid receptor mRNA in neurons associated with opioid receptor
6) Confidence 0.68 Published 1998 Journal Neuroendocrinology Section Abstract Doc Link 9508039 Disease Relevance 0.32 Pain Relevance 0.43
We examined the overexpression of the mu-opioid receptor in High Five insect cells, employing rat mu-receptor cDNA linked to variable lenghts of their native 5'UTR.
Spec (examined) Positive_regulation (overexpression) of Spec (examined) Gene_expression (overexpression) of mu-opioid receptor associated with opioid receptor
7) Confidence 0.68 Published 1999 Journal Life Sci. Section Abstract Doc Link 10201640 Disease Relevance 0.06 Pain Relevance 0.09
The present study was conducted to determine whether chronic exposure to the opioid antagonist naltrexone would similarly increase mu opioid receptor gene expression as measured by mRNA levels.
Spec (whether) Positive_regulation (increase) of Gene_expression (expression) of mu opioid receptor gene associated with antagonist, mu opioid receptor and opioid
8) Confidence 0.64 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750897 Disease Relevance 0 Pain Relevance 0.68
The results indicated a significant increase in spinal mu-opioid receptor expression on Days 6 and 21 after AA induction compared with the control group.
Positive_regulation (increase) of Gene_expression (expression) of mu-opioid receptor in spinal associated with opioid receptor and arthritis
9) Confidence 0.61 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671722 Disease Relevance 1.57 Pain Relevance 1.60
Increase of opioid mu-receptor gene expression in streptozotocin-induced diabetic rats.
Positive_regulation (Increase) of Gene_expression (expression) of mu-receptor associated with diabetes mellitus and opioid
10) Confidence 0.60 Published 2001 Journal Horm. Metab. Res. Section Title Doc Link 11544560 Disease Relevance 0.56 Pain Relevance 0.67
It was found that rats treated with vehicle, but not methadone, responded for the cocaine conditioned stimulus and displayed elevated mu-opioid receptor mRNA expression in the nucleus accumbens core and basolateral amygdala, reduced hypocretin/orexin mRNA in the lateral hypothalamus, and reduced D2 receptor mRNA in the caudate-putamen.
Positive_regulation (elevated) of Gene_expression (expression) of mu-opioid receptor mRNA in nucleus accumbens associated with nucleus accumbens, opioid receptor, methadone, amygdala and cocaine
11) Confidence 0.57 Published 2009 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 18990547 Disease Relevance 0 Pain Relevance 1.07
Results showed a significant increase in muOR expression in the NTS of morphine-dependent rats that received low doses of naltrexone in their drinking water, and increases in muOR expression were also found to be dose dependent.
Positive_regulation (increases) of Gene_expression (expression) of muOR associated with morphine
12) Confidence 0.55 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16385558 Disease Relevance 0.07 Pain Relevance 0.68
Results showed a significant increase in muOR expression in the NTS of morphine-dependent rats that received low doses of naltrexone in their drinking water, and increases in muOR expression were also found to be dose dependent.
Positive_regulation (increase) of Gene_expression (expression) of muOR associated with morphine
13) Confidence 0.55 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16385558 Disease Relevance 0.08 Pain Relevance 0.79
In conclusion, our previously reported decreases in c-Fos and PKA expression in the NTS following pretreatment with low doses of naltrexone may be partially explained by a greater inhibition of NTS neurons resulting from increased muOR expression in this region.
Positive_regulation (increased) of Gene_expression (expression) of muOR in neurons
14) Confidence 0.55 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16385558 Disease Relevance 0.06 Pain Relevance 0.54
We observed an increase in mu-opioid receptor mRNA levels in the ventromedial nucleus of the hypothalamus (VMH) and arcuate nucleus (ARN) after 48 h of 10 microg of 17-beta-estradiol-3-benzoate treatment when compared to OVX females.
Positive_regulation (increase) of Gene_expression (levels) of mu-opioid receptor in hypothalamus associated with opioid receptor
15) Confidence 0.50 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221910 Disease Relevance 0 Pain Relevance 0.40
Cat odor exposure induced a significant increase in the expression of pro-opio-melanocortin (POMC) and mu-opioid receptor (MOR) genes in the brain structures related to anxiety and motivation.
Positive_regulation (increase) of Gene_expression (expression) of mu-opioid receptor in brain structures associated with anxiety disorder and opioid receptor
16) Confidence 0.48 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15740852 Disease Relevance 0.10 Pain Relevance 0.57
Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats.
Positive_regulation (Elevated) of Gene_expression (expression) of mu-opioid receptor in nucleus associated with opiate, opioid receptor and withdrawal
17) Confidence 0.48 Published 2006 Journal J. Neurosci. Res. Section Title Doc Link 16385558 Disease Relevance 0.07 Pain Relevance 0.63
The results showed that ith morphine could increase the expression of mu-opioid receptor mRNA.
Positive_regulation (increase) of Gene_expression (expression) of mu-opioid receptor associated with opioid receptor and morphine
18) Confidence 0.47 Published 2000 Journal Acupunct Electrother Res Section Abstract Doc Link 10830970 Disease Relevance 0.26 Pain Relevance 0.98
However, it is also possible that E2 and P differentially regulate responsiveness to opioids by altering mu-opioid receptor gene expression.
Positive_regulation (altering) of Gene_expression (expression) of mu-opioid receptor gene associated with opioid receptor and opioid
19) Confidence 0.46 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9450674 Disease Relevance 0.08 Pain Relevance 0.23
Cloning and expression of an isoform of the rat mu opioid receptor (rMOR1B) which differs in agonist induced desensitization from rMOR1.
Positive_regulation (induced) of Gene_expression (expression) of rMOR1B associated with agonist and mu opioid receptor
20) Confidence 0.45 Published 1995 Journal FEBS Lett. Section Title Doc Link 7532594 Disease Relevance 0 Pain Relevance 0.38

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox