INT4891

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Context Info
Confidence 0.72
First Reported 1986
Last Reported 2010
Negated 3
Speculated 5
Reported most in Abstract
Documents 81
Total Number 86
Disease Relevance 35.27
Pain Relevance 53.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
DRG 22
plasma 12
motoneurons 4
trigeminal ganglia 4
neurons 4
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 576 100.00 Very High Very High Very High
Neuropeptide 67 100.00 Very High Very High Very High
substance P 67 100.00 Very High Very High Very High
calcitonin gene related peptide 50 100.00 Very High Very High Very High
Somatostatin 24 100.00 Very High Very High Very High
Enkephalin 8 100.00 Very High Very High Very High
dorsal root ganglion 53 99.84 Very High Very High Very High
Spinal cord 33 99.84 Very High Very High Very High
narcan 5 99.76 Very High Very High Very High
Migraine 32 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 74 99.84 Very High Very High Very High
Cyst 7 99.74 Very High Very High Very High
Headache 32 99.68 Very High Very High Very High
Arthritis 41 99.62 Very High Very High Very High
Nociception 22 99.62 Very High Very High Very High
Cancer 6 99.56 Very High Very High Very High
Temporomandibular Joint Syndrome 2 99.40 Very High Very High Very High
Neurogenic Inflammation 7 99.34 Very High Very High Very High
Necrosis 6 99.32 Very High Very High Very High
Injury 20 99.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, expression of calcitonin gene-related peptide (CGRP) and substance P mRNA was down-regulated 12 days following neurotomy.
Transcription (expression) of calcitonin gene-related peptide associated with substance p and calcitonin gene-related peptide
1) Confidence 0.72 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12787826 Disease Relevance 0.89 Pain Relevance 1.04
On the other hand, expression of calcitonin gene-related peptide (CGRP) and substance P mRNA was down-regulated 12 days following neurotomy.
Transcription (expression) of CGRP associated with substance p and calcitonin gene-related peptide
2) Confidence 0.72 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12787826 Disease Relevance 0.94 Pain Relevance 1.09
Adjuvant-induced joint inflammation causes very rapid transcription of beta-preprotachykinin and alpha-CGRP genes in innervating sensory ganglia.
Transcription (transcription) of CGRP in ganglia associated with inflammation and arthritis
3) Confidence 0.72 Published 2001 Journal J. Neurochem. Section Title Doc Link 11299299 Disease Relevance 0.63 Pain Relevance 0.57
GeneChip analysis revealed that neither estrogen nor contraction alone changed the mRNA expression of substance P, the neurokinin-1 receptor, CGRP, NGF, the P2X3 receptor, GABAA and GABAB, the 5-HT3A and 5-HT3B receptor, N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors, opioid receptors, and opioid-like receptor.
Transcription (expression) of CGRP associated with nmda receptor, opioid receptor, opioid and substance p
4) Confidence 0.69 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16306253 Disease Relevance 0.29 Pain Relevance 0.82
Previous studies have shown that calcitonin gene-related peptide (CGRP) mRNA steady-state levels and CGRP immunoreactivity in motoneurons of the spinal nucleus of the bulbocavernosus (SNB) are inversely related to the gonadal steroid environment in male rats.
Transcription (levels) of calcitonin gene-related peptide in motoneurons associated with calcitonin gene-related peptide
5) Confidence 0.69 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1315918 Disease Relevance 0 Pain Relevance 0.31
Previous studies have shown that calcitonin gene-related peptide (CGRP) mRNA steady-state levels and CGRP immunoreactivity in motoneurons of the spinal nucleus of the bulbocavernosus (SNB) are inversely related to the gonadal steroid environment in male rats.
Transcription (levels) of CGRP in motoneurons associated with calcitonin gene-related peptide
6) Confidence 0.69 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1315918 Disease Relevance 0 Pain Relevance 0.31
The contribution of calcitonin gene-related peptide and its receptors to transmission of presumed nociceptive information appears to be reduced in the sciatic nerve constriction model.
Transcription (contribution) of calcitonin in sciatic nerve associated with nociception, sciatic nerve and calcitonin gene-related peptide
7) Confidence 0.69 Published 1996 Journal Neuroscience Section Abstract Doc Link 9053804 Disease Relevance 0.31 Pain Relevance 1.19
Since the distribution of CGRP-I nerves of cerebral arteries among these species was the densest in guinea pigs, this animal was used to study the effect of several treatments on CGRP-I nerves.
Transcription (distribution) of CGRP-I in nerves associated with calcitonin gene-related peptide
8) Confidence 0.69 Published 1986 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 3490562 Disease Relevance 0 Pain Relevance 1.10
[Distribution of calcitonin gene-related peptide-like immunoreactive fibres in the temporomandibular joint of rat].
Transcription ([Distribution) of calcitonin gene-related peptide-like immunoreactive in temporomandibular joint associated with snapping jaw and calcitonin gene-related peptide
9) Confidence 0.69 Published 2000 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Title Doc Link 11831962 Disease Relevance 0.10 Pain Relevance 0.29
This study examined the effect of neonatal administration of capsaicin on nociceptive threshold and the distribution of calcitonin gene-related peptide (CGRP), substance P (SP), and fluoride-resistant acid phosphatase (FRAP) in the dorsal horn of the spinal cord during the course of development (10 days to 12 weeks of age) in the rat.
Transcription (distribution) of CGRP in dorsal horn associated with nociception, qutenza, dorsal horn, spinal cord, substance p and calcitonin gene-related peptide
10) Confidence 0.69 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1721077 Disease Relevance 0.17 Pain Relevance 0.65
This study examined the effect of neonatal administration of capsaicin on nociceptive threshold and the distribution of calcitonin gene-related peptide (CGRP), substance P (SP), and fluoride-resistant acid phosphatase (FRAP) in the dorsal horn of the spinal cord during the course of development (10 days to 12 weeks of age) in the rat.
Transcription (distribution) of calcitonin gene-related peptide in dorsal horn associated with nociception, qutenza, dorsal horn, spinal cord, substance p and calcitonin gene-related peptide
11) Confidence 0.69 Published 1991 Journal J. Comp. Neurol. Section Abstract Doc Link 1721077 Disease Relevance 0.17 Pain Relevance 0.65
Treatment with Rut significantly increased the synthesis and release of CGRP, as shown by the increase in the levels of CGRP mRNA and peptide in the dorsal root ganglia, the density of CGRP immunoreactive nerve fibers in the mesenteric artery, the CGRP content in the spinal cord and the plasma concentration of CGRP, which was markedly attenuated by pretreatment with capsaicin.
Transcription (levels) of CGRP in plasma
12) Confidence 0.69 Published 2004 Journal J. Hypertens. Section Body Doc Link 15311112 Disease Relevance 0 Pain Relevance 0
In situ hybridization on consecutive sections revealed that 5-HT2A receptor mRNA is colocalized with calcitonin-gene related peptide (CGRP) mRNA (100/104; 96.2%) but not with c-Ret mRNA (1/115; 0.9%).
Neg (not) Transcription (colocalized) of CGRP
13) Confidence 0.67 Published 2002 Journal Pain Section Abstract Doc Link 12237191 Disease Relevance 0.73 Pain Relevance 0.49
For determination of peptide encoding mRNAs distributed in DRG neurons, in situ hybridization histochemistry utilizing S-end-labeled oligonucleotides complimentary to sequences of preprosomatostatin (PPSOM), preprocalcitonin gene related peptide (PPCGRP), preprotachykinin (PPT), or preproneuropeptide Y (PPNPY) mRNA was performed.
Transcription (sequences) of CGRP in neurons associated with dorsal root ganglion
14) Confidence 0.67 Published 1996 Journal Peptides Section Abstract Doc Link 8899822 Disease Relevance 1.29 Pain Relevance 0.64
Expression of mRNA for CGRP1 receptors, muscarinic m2, m3 and m5 receptors and neurokinin1 (NK1) and NK3, receptors was detected.
Transcription (Expression) of CGRP
15) Confidence 0.67 Published 2000 Journal Auton Neurosci Section Abstract Doc Link 11593767 Disease Relevance 0.53 Pain Relevance 0.43
In addition, the gastric mucosal expression of mRNA for CGRP, the most potent neuropeptide released from the sensory afferent nerves, was analyzed in rats exposed to WRS with or without ghrelin pre-treatment.
Spec (analyzed) Transcription (expression) of CGRP in nerves associated with stress and neuropeptide
16) Confidence 0.67 Published 2005 Journal Inflammopharmacology Section Abstract Doc Link 16259727 Disease Relevance 0.34 Pain Relevance 0.23
The relative amount of mRNA in a tissue sample concentrated in Merkel cells was compared semiquantitatively to that from nearby tissue without Merkel cells. mRNAs for VIP, tyrosine hydroxylase, substance P were found in higher concentration in Merkel cells than in control tissues. mRNA for genes encoding pro-enkephalin, GAP-43, CGRP, NGF and BDNF were detected in the Merkel cell samples at concentration statistically equivalent to those found in the control tissues.
Transcription (detected) of CGRP in Merkel cells associated with enkephalin and substance p
17) Confidence 0.67 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794495 Disease Relevance 0 Pain Relevance 0.27
For determination of peptide encoding mRNAs distributed in DRG neurons, in situ hybridization histochemistry utilizing S-end-labeled oligonucleotides complimentary to sequences of preprosomatostatin (PPSOM), preprocalcitonin gene related peptide (PPCGRP), preprotachykinin (PPT), or preproneuropeptide Y (PPNPY) mRNA was performed.
Transcription (sequences) of preprocalcitonin gene related peptide in neurons associated with dorsal root ganglion
18) Confidence 0.66 Published 1996 Journal Peptides Section Abstract Doc Link 8899822 Disease Relevance 1.28 Pain Relevance 0.64
In adult animals treated as neonates with the sympathetic neurotoxin 6-hydroxydopamine, a virtual absence of TH-IR and NPY-IR fibers was observed, whereas the distribution of CGRP-IR and SP-IR fibers appeared unaltered.
Transcription (distribution) of CGRP-IR in sympathetic associated with substance p and calcitonin gene-related peptide
19) Confidence 0.66 Published 1990 Journal Cell Tissue Res. Section Abstract Doc Link 1973633 Disease Relevance 0 Pain Relevance 0.57
All above cultured samples were processed for detecting expression of mRNA for SP, CGRP and vanilloid receptor 1 (VR1) of DRG neurons by RT-PCR, and VR1 protein expression by Western blot.
Transcription (expression) of CGRP in DRG
20) Confidence 0.66 Published 2006 Journal Neuro Endocrinol. Lett. Section Body Doc Link 17187013 Disease Relevance 0.09 Pain Relevance 0

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