INT48910

Context Info Confidence 0.78 First Reported 1994 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 0.43 Pain Relevance 0.42

mitochondrion (DECR1) small molecule metabolic process (DECR1) nucleolus (DECR1) nucleus (DECR1) cytoplasm (DECR1)

Anatomy Link Frequency nerve 2 uterus 1 vagina 1 nerve cells 1 microglia 1 DECR1 (Homo sapiens)

Pain Link Frequency Relevance Heat Neuronal nitric oxide synthase 3 100.00 Enkephalin 2 78.48 substance P 2 77.52 Neuropeptide 4 75.00 qutenza 5 25.00 antagonist 2 5.00 palliative 1 5.00 fibrosis 1 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 3 99.84 Neurodegenerative Disease 1 77.20 Metastasis 18 66.20 Prostate Cancer 53 50.00 Cancer 49 48.72 Disease 15 39.20 Adenocarcinoma 1 19.24 Apoptosis 8 5.00 Hypersensitivity 4 5.00 Hyperplasia 2 5.00

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By double staining, 70 approximately 77% of neurons showed colocalization of NADPH-d and acetylcholinesterase in the uterus and vagina.

Localization (colocalization) of NADPH in vagina

1) Confidence 0.78 Published 2000 Journal Auton Neurosci Section Abstract Doc Link 11109984 Disease Relevance 0 Pain Relevance 0.15

Together, our data suggest that TRPV1 channels are involved in regulating NADPH oxidase-mediated ROS generation in microglia.

Localization (oxidase) of NADPH in microglia

2) Confidence 0.73 Published 2009 Journal J. Neuroimmunol. Section Abstract Doc Link 19683814 Disease Relevance 0.08 Pain Relevance 0

By double staining, 70 approximately 77% of neurons showed colocalization of NADPH-d and acetylcholinesterase in the uterus and vagina.

Localization (colocalization) of NADPH in uterus

3) Confidence 0.26 Published 2000 Journal Auton Neurosci Section Abstract Doc Link 11109984 Disease Relevance 0 Pain Relevance 0.15

HPN, NDN, ATR, ABL2, DHRS2), development and cellular differentiation (CLEC3B, KCNJ8, ADAM29, DNMT3A), fatty acid and steroid metabolism (LPIN1, DECR1, ACSL3) and intracellular signaling transduction (PPAP2C, PPP3CA, PRSS23, GRB10, SIPA1L2).

Localization (metabolism) of DECR1

4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.13 Pain Relevance 0

We found complete co-localization of neuronal nitric oxide synthase and NADPH-d in ganglion cells, and in nerve fibres around acini, excretory ducts, blood vessels and in islets of Langerhans of rat and human pancreas.

Localization (co-localization) of NADPH-d in nerve associated with ganglion cysts and neuronal nitric oxide synthase

5) Confidence 0.04 Published 1994 Journal Histochemistry Section Abstract Doc Link 7532638 Disease Relevance 0.10 Pain Relevance 0.05

In this study, we wished to clarify the distribution and co-localization of nitric oxide synthase and NA-DPH-diaphorase (NADPH-d) in nerve cells, nerve fibres and parenchymal cells in exocrine and endocrine pancreas, and to assess the influence of fixation on the staining pattern obtained.

Localization (co-localization) of NADPH-d in nerve

6) Confidence 0.04 Published 1994 Journal Histochemistry Section Abstract Doc Link 7532638 Disease Relevance 0.06 Pain Relevance 0.03

In this study, we wished to clarify the distribution and co-localization of nitric oxide synthase and NA-DPH-diaphorase (NADPH-d) in nerve cells, nerve fibres and parenchymal cells in exocrine and endocrine pancreas, and to assess the influence of fixation on the staining pattern obtained.

Localization (co-localization) of NADPH-d in nerve cells

7) Confidence 0.01 Published 1994 Journal Histochemistry Section Abstract Doc Link 7532638 Disease Relevance 0.06 Pain Relevance 0.03

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